Reduced grey matter volume of amygdala and hippocampus is associated with the severity of autistic symptoms and language abilities in school-aged children with Autism Spectrum Disorder: an exploratory study

Brain Structure and Function. 2023. Vol. 228. No. 6. P. 1573–1579.

Arutiunian V., Davydova E., Pereverzeva D., Sorokin A., Tyushkevich S., Mamokhina U., Danilina K., Dragoy O.

The core symptoms of Autism Spectrum Disorder (ASD) are impairments in social interaction/communication and the presence of stereotyped and repetitive behaviour. The amygdala and hippocampus are involved in core functions in the “social brain” and, thus, may be of particular interest in ASD. Previous studies demonstrated inconsistent results, revealing both increased and reduced volume of these brain structures in individuals with ASD. In this study, we investigated the grey and white matter volumes of amygdala and hippocampus in primary-school-aged children with and without ASD. Also, we assessed the relationships between the volume of brain structures and behavioural measures in children with ASD. A total of 36 children participated in the study: 18 children with ASD (13 boys, age range 8.01–14.01 years, mean age (Mage) = 10.02, standard deviation (SD) = 1.76) and 18 age- and sex-matched typically developing controls (13 boys, age range 7.06–12.03 years, Mage = 10.00, SD = 1.38). The whole-brain structural magnetic resonance imaging (MRI) was applied to acquire T1 images for each child. The results showed a bilateral reduction in grey matter volume of amygdala and hippocampus in children with ASD, but no difference was found in white matter volume. Importantly, pathological reduction in grey matter volume of amygdala was associated with lower language skills and more severe autistic traits; also, a reduced grey matter volume of the left hippocampus was related to lower language skills in the ASD group.

Keywords: язык, language, коммуникация, communication, аутизм, гиппокамп, hippocampus, амигдала, amygdala, Autism Spectrum Disorder (ASD)

Publication based on the results of: Neuroanatomical foundations of language disorders in children and adults (2023)