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Международные Четвериковские чтения: сборник трудов конференции (26-27 апреля 2021 г., Пущино, Московская область, Россия)
Pushchino :
-, 2021.
Under the general editorship: Т. Г. Щербатюк, И. С. Масулис, Т. И. Хохлова
Chapters
Чеботарева О. Е., В кн.: Международные Четвериковские чтения: сборник трудов конференции (26-27 апреля 2021 г., Пущино, Московская область, Россия).: Пущино: Фонд "Предприниматели за развитие города Пущино", 2021. С. 53–57.
Рекомбинантный белок - это белок, претерпевший определённые модифицикации и кодирующийся рекомбинантной (модифицированной) ДНК. Рекомбинантная ДНК как правило представляет собой плазмиду, в которой ген (или гены - их может быть несколько) целевого белка, располагается после промоторной области. Когда плазмида вводится в систему экспрессии хозяина, его белок-синтезирующий аппарат обеспечивает продукцию 54 выбранного белка. Это позволяет получить большие ...
Added: May 13, 2023
Language:
Russian
Khodadoust J., Kulikova S., Khodadoust F., Biomedical Signal Processing and Control 2027 Vol. 129 P. 111284–111284
Acute ischemic stroke (AIS) analysis from two-dimensional (2D) clinical imaging is hindered by uncontrolled slice tilt and geometric inconsistencies that violate the assumptions of pose-agnostic deep learning (DL) models. This paper proposes a unified geometry-aware, frequency-domain framework for tilted slice localization and ischemic stroke segmentation that explicitly decouples pose estimation from lesion analysis. The method ...
Added: September 2, 2026
Bubnova M., Chetverikov V., Pozhidaev E., Информационные технологии 2026 Т. 32 № 8 С. 404–413
A specialized methodology was developed, computer modeling was conducted, and a comparative analysis was performed for autonomous control methods for small spacecraft, differing in how the nonlinearity of the initial stabilization problem is taken into account:
— control constructed using a system of linear differential equations (SLDE);
— control constructed using SLDE applied to a more general ...
Added: September 2, 2026
Кубкин Я. В., Российский кардиологический журнал 2026 Т. 31 № 8S
Goal. To assess the contribution of polygenic risk scores to the short‑term mortality prediction model in patients with dilated cardiomyopathy (DCM).
Materials and methods. The study included 137 patients with DCM. The mean age was 56.8 ± 13.5 years; there were 115 men (83.9 %). The median follow‑up period was 17 [13; 22] months. During the follow‑up period, 26 ...
Added: August 24, 2026
Tsydypova M., Современные проблемы дистанционного зондирования Земли из космоса 2026 Т. 23 № 3 С. 263–275
The article presents a methodology for mapping coniferous forest decline, based on the integration of automated remote sensing data interpretation techniques, vegetation indices, remote sensing data on above-ground biomass (Biomass CCI (Climate Change Initiative)), and materials from ground-based forest pathology surveys using forests of the Khamar-Daban ridge (Republic of Buryatia) as a case study. The ...
Added: August 9, 2026
Elena A. Andresyuk, Natalya O. Porozova, Londaridze G. et al., Frontiers in Oncology 2026 Vol. 16 Article 1875861
Inhibition of the PD-1/PD-L1 axis has become a clinical standard across multiple malignancies, yet durable benefit remains restricted to selected settings, and many biologically rational combinations fail to maintain clinical benefit in late-phase evaluation. This structured, registry-derived narrative review, supported by expert-guided interpretation, was designed to identify the most clinically meaningful development directions among strategies ...
Added: July 31, 2026
Manivelan S. V., Srinivasan S., Thamilmaran K. et al., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 No. 1 Article 014217
This study investigates the dynamical origins and statistical properties of extreme events (EEs) in a diffusively coupled theoretical Brusselator system, extending from pairwise interactions to globally coupled networks. Statistically, the emergence of EEs is characterized by heavy-tailed probability density functions and exponential interevent interval distributions, alongside an analysis of the complementary cumulative distribution function and ...
Added: July 15, 2026
Wang R., He Y., Myachykov A. et al., Neuroimage 2026 Vol. 332 Article 121926
Insomnia disorder (ID) exhibits considerable heterogeneity in neuroimaging findings across studies, and whether functional brain alterations are consistent across resting and task states remains unclear. This study aimed to identify neural dysfunction across states in ID and explore its transcriptomic correlates. ...
Added: July 13, 2026
Shestoperov A. I., Ivchenko A., Fomina E. V., Microgravity Science and Technology 2025 Vol. 37 Article 19
The paper is dedicated to the analysis of medico-biological data obtained during locomotor testing of astronauts. Accurate data interpretation plays a crucial role in locomotion system monitoring, prophylaxis of long-duration spaceflight negative effects and thus in the development of an autonomous medical support system for deep space expeditions. During the locomotor testing the astronaut changes ...
Added: June 26, 2026
Мелешко Е. В., Афанасенко Т. С., Ш. М. Гаджимирзаев et al., Компьютерные исследования и моделирование 2022 Т. 14 № 6 С. 1255–1268
This work contains a description of the results of modeling the process of maintaining the readiness of a section of the road network under strikes of with specified parameters. A one-dimensional section of road up to 40 km long with a total number of strikes up to 100 during the work of the brigade is ...
Added: June 26, 2026
Vasilev R., Savchenko A., Blinov P. et al., Frontiers in Medicine 2026 Vol. 13 Article 1778404
Automated disease screening systems face challenges when applied to multi-class medical image analysis, particularly under severe class imbalance inherent in clinical datasets. Retinal fundus imaging enables non-invasive screening for multiple ocular and systemic diseases simultaneously, yet current automated systems typically assess risk for only a single pathology or a limited disease range. We developed a ...
Added: June 16, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
ЯКУБЕНКО Т. В., Plotnikov S., Ratio et Natura 2024 № 3 (11) Статья 10
The article presents the results of our own research aimed at studying the prospects of using genetic sequencing technologies to identify the risk of having children with genetic abnormalities. ...
Added: May 21, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Thangavel B., Kathamuthu T., Srinivasan S., International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 2026 Vol. 36 No. 09 Article 2630019
In this paper, we report, for the first time, that Extreme Events (EEs) can robustly emerge in autonomous, weakly coupled Bonhoeffer–van der Pol oscillators, challenging the prevailing notion that strong interaction and external drive are necessary for such rare, large-amplitude bursts. Our central finding is a novel dynamical route to EEs: a transition from quasi-periodic torus dynamics to ...
Added: May 20, 2026
Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42
Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere.
Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...
Added: May 18, 2026
Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110
Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...
Added: April 29, 2026
Kychkin A., Chernitsin I., Прикладная информатика 2026 № 1(121) С. 40–58
The results of the development of a software microservice embedded in atmospheric air quality monitoring systems to support the identification of industrial pollution sources are presented. The emission and subsequent spread of harmful substances in the lower layers of the atmosphere is dynamic and characterized by high uncertainty due to the specific features of technological ...
Added: April 23, 2026
Krasnov L., Malikov D., Kiseleva M. et al., Journal of Medicinal Chemistry 2026 Vol. 69 No. 8 P. 8838–8851
In this work, we developed a straightforward data-driven approach to predict the cytotoxicity of metal complexes based entirely on their (metal + ligands) composition. To this end, we have manually curated MetalCytoToxDB─a comprehensive experimental database comprising 26,500 IC50 values for 7050 metal complexes against 754 cell lines from 1921 articles. Based on these, machine learning ...
Added: April 23, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Данилова Н. В., Олейникова Н. А., Михайлов И. А. et al., М.: КДУ, Университетская книга, 2025.
This textbook contains all the lectures from the pathological anatomy course at the Faculty of Fundamental Medicine of Lomonosov Moscow State University. The total duration of video recordings is over 50 hours. Each lecture has a brief summary. The accessible presentation of the material will allow you to effectively use your knowledge in preparation for ...
Added: March 3, 2026
Екатеринбург: ФГБОУ ВО УГМУ Минздрава России, 2025.
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Федеральное государственное бюджетное образовательное учреждение
высшего образования
«Уральский государственный медицинский университет»
Министерства здравоохранения Российской Федерации
Научное общество молодых ученых и студентов
Медицинское образование, наука,
практика
Сборник статей X Международной научно-практической конференции
молодых ученых и студентов
Medical education, science, practice
22-23 апреля 2025 г. ...
Added: March 2, 2026
М.: Международный центр «Новые научные исследования», 2025.
Сборник содержит статьи участников Международной научно-практической конференции «Научные открытия и инновационные стратегии», состоявшейся 24 мая 2025 г. в г. Москва.
В сборнике научных трудов рассматриваются современные научные проблемы и практики применения результатов научных исследований. Материалы сборника предназначены для научных работников, преподавателей, аспирантов, магистрантов, студентов в целях применения в научной работе и учебной деятельности. Ответственность за аутентичность ...
Added: February 18, 2026
Filippova E., Sukhikh T., Tychinina A. et al., Crystals 2026 Vol. 16 No. 1 Article 12
Reaction of [Zr(η5-Cp’)2Cl2] (Cp’ = tBuC5H4) and Na2Cat36 (Cat36 = 3,6-di-tert-butylcatecholate) leads to the formation of the complexes [Na2Zr(Cat36)3(THF)2(C7H8)] (1) and [Zr(η5-Cp’)2(η1-Cp’)2] (2). Complex 1 along with its congeners [K2Zr(Cat36)3(THF)2] (3), [Li(THF)4][LiZr(Cat36)3] (4) and [Li4Zr(Cat36)4(dme)2] (5) were synthesized by the reaction of [ZrCl4(THF)2] and corresponding alkali metal catecholate M2Cat36. The complexes obtained were characterized by means of single-crystal X-ray diffraction ...
Added: February 18, 2026
Манышев С. Б., Этнография 2026 № 1 С. 6–29
The article considers the history of the institutionalization of Soviet Caucasian studies in the 1920s and 1930s based on archival documents, published materials and literary sources. The author analyzes the transition from local history organizations emerging at the dawn of Soviet power to more serious research institutes. The origins of the local history movement in ...
Added: February 2, 2026