?
Эпителиально-мезенхимальный переход в плаценте при преэклампсии
Акушерство и гинекология. 2016. № 12. С. 53–57.
Вишнякова П. А., Тарасова Н. В., Володина М.А., Марей М. В., Ходжаева З. С., Кан Н. Е., Высоких М. Ю.
Чеботарева О. Е., Пирогов А. А., Antipenko I. et al., Доклады российской академии наук. Науки о жизни 2026 Т. 529 № 1 С. 389–395
Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) ...
Added: September 16, 2026
Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12
Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...
Added: December 22, 2025
Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126
Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...
Added: December 2, 2025
Балакина А. А., Приходченко Т. Р., Якушев И. А. et al., Известия Академии наук. Серия химическая 2023 Т. 72 № 7 С. 1618–1632
The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and ...
Added: September 14, 2025
Вишнякова П. А., Киселева В. В., Полтавец А. С. et al., Вестник Российского университета дружбы народов. Серия: Медицина 2025 Т. 29 № 3 С. 335–352
Relevance. Preeclampsia is a severe complication of pregnancy, occurring in 8% of cases and causing high maternal and perinatal mortality and morbidity. The etiology of preeclampsia is still a subject of research, however, more and more data indicate the involvement of innate immune cells, monocytes, in the pathogenesis of this dangerous pathology. The aim of ...
Added: September 12, 2025
Knyazev E., Vishnyakova P., Lazareva O. et al., Biochip Journal 2025 Vol. 19 P. 1–21
Preeclampsia is a complex pregnancy disorder marked by hypertension and proteinuria, often resulting in significant maternal and fetal morbidity and mortality. Understanding its pathogenesis is crucial for developing effective diagnostic and therapeutic strategies. Given the placenta’s central role in preeclampsia, it remains a focal point for research. This review offers a comprehensive overview of current ...
Added: December 16, 2024
Vishnyakova P., Gantsova E., Kiseleva V. et al., Placenta 2024 Vol. 145 P. 151–161
Introduction
The role of the TGFβ signaling pathway, an important cascade responsible for the anti-inflammatory polarization of macrophages, in the development of both early- and late-onset preeclampsia (eoPE and loPE), remains poorly understood. In this study, we examined the components of the TGFβ signaling cascade and macrophage markers within placental tissue in normal pregnancy and in ...
Added: December 8, 2023
Karpukhina A., Galkin I., Ma Y. et al., Redox Biology 2021 Vol. 43 Article 102008
Muscles of patients with facioscapulohumeral dystrophy (FSHD) are characterized by sporadic DUX4 expression and oxidative stress which is at least partially induced by DUX4 protein. Nevertheless, targeting oxidative stress with antioxidants has a limited impact on FSHD patients, and the exact role of oxidative stress in the pathology of FSHD, as well as its interplay with the DUX4 expression, remain unclear. ...
Added: December 10, 2022
Bocharov E., Nadezhdin K., Urban A. et al., ACS Chemical Biology 2019 Vol. 14 No. 7 P. 1573–1582
Alzheimer’s disease is an age-related pathology associated with accumulation of amyloid-β peptides, products of enzymatic cleavage of amyloid-β precursor protein (APP) by secretases. Several familial mutations causing early onset of the disease have been identified in the APP transmembrane (TM) domain. The mutations influence production of amyloid-β, but the molecular mechanisms of this effect are ...
Added: August 8, 2019
Высоких М. Ю., Тютюнник В. Л., Кан Н. Е. et al., Акушерство и гинекология 2017 № 4 С. 62–67
...
Added: October 25, 2018
Петушкова Н., Русанов А., Згода В. et al., Молекулярная биология 2017 Т. 51 № 5 С. 857–869
Oxidative stress is a universal response of the skin cell damage of various origins. Sodium dodecyl sulfate (SDS, sodium lauryl sulfate) is an anionic surfactant commonly used as an emulsifying detergent in household cleaners. Sodium dodecyl sulfate is the reference compound for testing toxicity on cellular skin models. The effect of sodium dodecyl sulfate in ...
Added: March 14, 2018