Структура и биологическая активность нитроксисукцината 3-гидрокси-6-метил-2-этилпиридиния

Известия Академии наук. Серия химическая. 2023. Т. 72. № 7. С. 1618–1632.

Балакина А. А., Приходченко Т. Р., Якушев И. А., Амозова В. И., Мумятова В. А., Корнев А. Б., Terentiev A., Гадомский С. Я., Дороватовский П. В., Федоров Б. С., Мищенко Д. В.

The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and tumor cells. The ability of 2 to increase the intracellular content of nitrogen monoxide due to the presence of nitroxysuccinate in its structure has been shown. Compound 2 suppressed the processes of lipid peroxidation in mouse brain homogenate, unlike 3-hydroxy-6-methyl-2-ethylpyridinium succinate (1). In addition, compared with compound 1, compound 2 more effectively reduced the intracellular content of reactive oxygen species during the induction of oxidative stress by tert-butyl hydroperoxide, and had a greater ability to bind superoxide. The data obtained show the high prospects of this compound for the development of drugs with antioxidant activity.

Keywords: рентгеноструктурный анализ, оксид азота, Reactive oxygen species, окислительный стресс, Oxidative stress, активные формы кислорода, nitro compounds, X-ray diffraction analysis, нитросоединения, nitric oxide