Структура и биологическая активность нитроксисукцината 3-гидрокси-6-метил-2-этилпиридиния

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Структура и биологическая активность нитроксисукцината 3-гидрокси-6-метил-2-этилпиридиния

Известия Академии наук. Серия химическая. 2023. Т. 72. № 7. С. 1618–1632.

Балакина А. А., Приходченко Т. Р., Якушев И. А., Амозова В. И., Мумятова В. А., Корнев А. Б., Terentiev A., Гадомский С. Я., Дороватовский П. В., Федоров Б. С., Мищенко Д. В.

The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and tumor cells. The ability of 2 to increase the intracellular content of nitrogen monoxide due to the presence of nitroxysuccinate in its structure has been shown. Compound 2 suppressed the processes of lipid peroxidation in mouse brain homogenate, unlike 3-hydroxy-6-methyl-2-ethylpyridinium succinate (1). In addition, compared with compound 1, compound 2 more effectively reduced the intracellular content of reactive oxygen species during the induction of oxidative stress by tert-butyl hydroperoxide, and had a greater ability to bind superoxide. The data obtained show the high prospects of this compound for the development of drugs with antioxidant activity.

Research target: Chemistry Biology

Language: Russian

DOI

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Detailed data on anatomy of the coelomic system and ultrastructure of the lophophore coelom in brachiopod Novocrania anomala with discussion of the phylogenetic significance

Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195

Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...

Added: October 11, 2026

Electrochemical reduction of cyanide on conjugated copper-organic framework Cu3(HHTP)2 monolayer: A dispersion-corrected DFT investigation.

Shi R., Yu Y., Чибисов А. Н., International Journal of Hydrogen Energy 2025 Vol. 107 P. 52–62

Cyanide containing wastewater can cause livestock death and reduce agricultural production and electrochemical reduction of cyanide (CNRR) is a promising way to eliminate its harm and turn waste into valuable products. However, the reaction mechanism and function of electrocatalysts for CNRR have not been fully understood yet. Herein we identify a two-dimensional (2D) conductive copper-organic ...

Added: October 11, 2026

Nanometer thick iron garnet films with high Faraday rotation

Gribova N. I., Osmanov S. V., Lyashko S. D. et al., Journal of Magnetism and Magnetic Materials 2025 No. 614 P. 1–8

Here we demonstrate nanometer thick iron garnet films with high specific Faraday rotation suitable for the magneto-optical applications. Bismuth-substituted iron garnet films of compositions Bi1Y2Fe5O12 and Bi1Tm2Fe5O12 deposited on gadolinium gallium garnet substrate are fabricated and characterized. Their thicknesses range from 2 to 10 nm, which corresponds to just a few crystal lattice constants. Spectacularly, Faraday rotation of the ...

Added: October 4, 2026

HLA class I escape drives the evolution of SARS-CoV-2 in human populations

Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20

The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...

Added: October 2, 2026

Advances in colloidal anisotropic nanocrystals for high-efficiency light-emitting diodes

Zhukov A., Chen F., Zeng Y. et al., Nanoscale 2026 Vol. 18 No. 36 P. 19223–19253

Colloidal semiconductor nanocrystals have emerged as promising materials for next-generation light-emitting diodes (LEDs) owing to their solution processability, tunable emission wavelengths, narrow emission linewidths, and high photoluminescence quantum yields. Among them, anisotropic nanocrystals, including one-dimensional nanorods (NRs) and two-dimensional nanoplatelets (NPLs), offer additional opportunities for controlling transition dipole moment orientation and light out-coupling efficiency. These ...

Added: October 2, 2026

Effect of the hydrogen bond donor nature on the extraction ability of a tributyl phosphate-based deep eutectic solvent

Мальцева В. Е., Ananyev I., Milevskii N. et al., Molecular Systems Design and Engineering 2026 Vol. 11 No. 7 P. 691–704

The use of hydrophobic deep eutectic solvents (DESs) as extractants for metal ion separation is largely due to the ease of their preparation and the possibility of modifying them depending on the composition of the metal mixture to be separated. However, the most common approach to DES modification involves the replacement of the extractant, while ...

Added: October 2, 2026

Crystal Structure and 35Cl NQR Spectroscopy in Сhlorinated closo-Dodecaborate Clusters {[(Me2CO)Ag(μ-Me2CO)2Ag(Me2CO)][μ-B12Cl12]}n and {[DMFAg(μ-DMF)2AgDMF][μ-B12Cl12]}n

Мальцева В. Е., Ananyev I., Golubev A. V. et al., Russian Journal of Inorganic Chemistry 2026 Vol. 71 P. 724–736

Two voluminous polymer silver(I) salts of perchlorinated dodecoborate clusters, {[(Me2CO)Ag(μ-Me2CO)2Ag(Me2CO)][μ-B12Cl12]}n (1) and {[DMFAg(μ-DMF)2AgDMF][μ-B12Cl12]}n (2) were synthesized. The 35Cl nuclear quadrupole resonance (NQR) spectroscopy supplemented with the X-ray diffraction data was applied for identifying and analyzing noncovalent interactions Cl···X in these salts. Whereas in X-ray diffraction, noncovalent interactions are associated with the presence of the shortened ...

Added: October 2, 2026

High-Resolution X‑ray Diffraction of TeII-Centered Chalcogen Bonds: Direct Visualization of σ–Holes and Quantitative Bonding Analysis

Мальцева В. Е., Rozhkov A., Ananyev I. et al., Inorganic Chemistry 2026 Vol. 65 No. 22 P. 12484–12496

Despite the well-established importance of chalcogen bonding in crystal engineering and supramolecular chemistry, experimental charge density data for TeII-centered chalcogen bonds have remained entirely absent, leaving the electronic nature of these interactions uncharacterized at the level of directly measured electron density. Here, we report the first high-resolution X-ray diffraction (HRXRD) study of TeII-centered chalcogen bonds, ...

Added: October 2, 2026

Pericyte-derived cancer-associated fibroblasts correlate with poor survival and are enriched after chemoradiotherapy in glioblastoma

Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902

Added: October 2, 2026

High Temperature Oxidation Resistance of Off-Stoichiometric (Ni39.6Co29.3Cr10Al15.8Ta3.3Nb2)98.5B1.5 Chemically Complex Intermetallic Alloy

Ostovari Moghaddam A., Mehrabi-Kalajahi S., Solizoda I. A. et al., Metals and Materials International 2026 P. 1–9

Off-stoichiometric boron-doped chemically complex intermetallic alloys (CCIMAs) have recently emerged as a new avenue for overcoming the low temperature brittleness of ordered superlattices. However, their behavior at high temperatures remains unexplored. In this study, a novel (Ni39.6Co29.3Cr10Al15.8Ta3.3Nb2)98.5B1.5 CCIMA was prepared and its oxidation resistance over a wide temperature range (500 °C–950 °C) was studied. The ...

Added: October 1, 2026

Профессиональная учебная практика: I курс. Введение в биотехнологию, клеточную и молекулярную биологию : учебно-методическое пособие для студентов и преподавателей

Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.

This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...

Added: September 30, 2026

Анализ in silico вероятных зависимостей «структура-активность» этанола

Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91

Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...

Added: September 29, 2026

MPI+OpenMP implementation of resolution-of-the-identity Hartree-Fock method exploiting permutational symmetry of three-center electron repulsion integrals

Kashpurovich I., Oleynichenko A., Stegailov V., Supercomputing Frontiers and Innovations 2026 Vol. 13 No. 1 P. 52–73

We report a high-performance implementation of the resolution-of-the-identity Hartree–Fock method that fully exploits the permutational symmetry of three-center electron repulsion integrals (ERI). The present implementation adopts a hybrid MPI+OpenMP parallelization strategy. Two different algorithmic approaches (with and without the pre-transformation of ERIs) are compared. A custom data layout introduced previously is employed. Designed to efficiently ...

Added: September 28, 2026

Thermodynamic Stabilization of PbS Quantum Dots for High-Performance Short-Wave Infrared Photodetection

Li Y., Han J., Zaman N. et al., ACS Applied Materials & Interfaces 2026 Vol. 18 No. 39 P. 54241–54251

The development of lead sulfide (PbS) quantum dot (QD) photodetectors for short-wave infrared (SWIR) applications has been fundamentally limited by the thermodynamic instability of large PbS QD facets, which leads to aggregation and epitaxial fusion. In this work, robust thermodynamic stabilization was achieved by introducing methylammonium chloride (MACl) in PbS QD surface passivation, as validated ...

Added: September 26, 2026

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Gureev M., Advanced Science 2026 P. 1–13

Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...

Added: September 26, 2026

Critical dynamics of conformational exchange in a nearcritical solvent: A statistical-mechanical three-mode theory

Budkov Y., Kiselev M. G., Journal of Chemical Physics 2026 Vol. 165 No. 12 Article 124508

We develop a three-mode statistical-mechanical theory for a two-conformer solute in a near-critical solvent. A compressible lattice model with vacancies yields the Gaussian free-energy functional for a critical conserved density, an orthogonal noncritical conserved mode, and the local conformer fraction. Their couplings follow from packing and cohesive interactions, rather than being introduced phenomenologically. Kawasaki transport of the two conserved fields and ...

Added: September 24, 2026

Multilayer Membranes Based on MK-40 for Electrodialysis Separation of Ions

Yurova P., Stenina I., Yaroslavtsev A. B., Membranes and Membrane Technologies 2026 Vol. 8 No. 1 P. 1–8

In this work, the effect of applying layers of polyethyleneimines with different molecular weights (1300 and 25000 Da), polystyrene sulfonic acid or sodium polyacrylate on the surface of the heterogeneous membrane MK-40 on the selectivity to singly charged ions was investigated. It is shown that the modification leads to an increase in the selectivity coefficients P(Na+/Ca2+) and P(Li+/Mg2+), ...

Added: September 24, 2026

A28-04 Measuring the Polygenic Risk of Thrombosis May Accelerate the Detection of Chronic Thromboembolic Pulmonary Hypertension Among Other Forms of Pulmonary Hypertension

Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212

Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...

Added: September 23, 2026

Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome

Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324

Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...

Added: September 23, 2026

Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis

Лосев М. А., Козлов А. С., Kliuev F. et al., Organic and Biomolecular Chemistry 2023 Vol. 21 No. 42 P. 8477–8481

A simple and atom-efficient way to prepare amides directly from carboxylic acids and nitroarenes was developed. Carbon monoxide as a sole reducing agent provides the ultimate selectivity of the protocol. A straightforward and selective way for the preparation of amides from nitroarenes and carboxylic acids using carbon monoxide as a reductant was developed. This protocol ...

Added: May 22, 2026

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544

Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...

Added: April 15, 2026

Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives

Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. 34 No. 6 P. 1–8

The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...

Added: April 15, 2026

A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene

Egorov E., Kondratenko N., Averina O. et al., Biochemistry. Biokhimiia 2023 Vol. 88 P. 1987–1996

Transcription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of particular interest for studying aging. In the present work, the CRISPR/Cas9 genome editing technology was used to generate the NRF2ΔNeh2 mice containing a substitution of eight amino acid residues at the N-terminus of the NRF2 protein, upstream of ...

Added: March 20, 2026

Bis(1,2,4-triphenylcyclopentadienyl) Terbium 4,4,4-trifluoro-1-phenylbutane-1,3-dionate

Daniil A. Bardonov, Minyaev M. E., Puntus L. et al., MolBank 2025 Vol. 2025 No. 4 Article M2102

A new bis(cyclopentadienyl) terbium(III) complex with 1,2,4-triphenylcyclopentadienyl and 4,4,4-trifluoro-1-phenylbutane-1,3-dionate ligands was synthesized. Single-crystal X-ray analysis revealed a mononuclear bis(cyclopentadienyl) complex with a diketonate ligand in the bisector plane. The compound under study exhibits a ligand ligand charge transfer state (LLCT), according to optical spectroscopy and crystallographic data. ...

Added: February 19, 2026