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Экспрессия генов изоформ тиоредоксина и тиоредоксинредуктазы при формировании лекарственной устойчивости опухолевых клеток к доксорубицину
ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия. 2012. Т. 10. № 5. С. 51–57.
Калинина Е. В., Березов Т. Т., Чернов Н. Н., Штиль А. А., Глазунова В.А., Нумурадов Н. К., Новичкова Н. Д.
Language:
Russian
Sakevich V. I., Демографическое обозрение 2026 Т. 13 № 3 С. 4–28
The article analyzes modern legislation regarding artificial termination of pregnancy in countries around the world. Depending on the grounds on which abortion is permitted, five groups of countries are distinguished. Estimates have shown that about 60% of women of reproductive age live in countries with liberal legislation, where abortion is allowed at the request of ...
Added: October 15, 2026
Lungu M. M., Davitadze A., Frontiers in Public Health 2026 Vol. 14 Article 1919768
Malaria control in Malawi relies primarily on long-lasting insecticide-treated nets (LLITNs) and indoor residual spraying (IRS), but transmission remains heterogeneous across districts. Previous research indicates that community-based environmental management strategies, such as routine drainage maintenance, vegetation removal, and effective household waste disposal, may reduce environmental conditions conducive to malaria vector proliferation. This study investigated the ...
Added: October 15, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Ari G., Liu X., Jiang L. et al., Ecological Indicators 2026 Vol. 191 Article 115592
Snow drought has become a research hotspot due to its widespread impacts on ecosystems and water resources, yet its effects on vegetation phenology remain relatively understudied. Focusing on the Mongolian Plateau, this study used the Snow Water Equivalent Index and the start of growing season (SOS) to assess the associations between snow drought and vegetation ...
Added: October 12, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Didenkulova E., Chugunov V., Didenkulova I., Wave Motion 2026 Vol. 147 Article 103787
This work presents a new analytical solution of the shallow water theory for cylindrical propagation of long tsunami-like waves in the basin of variable depth. Considered model cases are related to tsunami wave propagation from an asteroid fallen into the sea, or from underwater volcanic eruptions. The corresponding bottom geometries represent radially symmetric obstacles such ...
Added: October 8, 2026
Flamarion M., Didenkulova E., Pelinovsky E., Physics Letters A 2026 Vol. 598 Article 132218
In this letter, bipolar solitary wave interactions in the Schamel equation are revisited numerically. Two simulation settings are considered: repeated collisions in a periodic domain, and the interaction of a positive solitary wave with a train of negative polarity solitary waves of equal amplitude. In the first case, when the amplitudes are comparable, the larger ...
Added: October 8, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Le M. T., Шукуров И. С., Курск: Закрытое акционерное общество "Университетская книга", 2026.
This monograph studies the thermal characteristics of urban habitats and analyzes the impact of urban morphology on the emergence of urban heat island effects (UHI), particularly in the context of high-density urban development, modern high-rise buildings and related sanitary standards. It presents comprehensive findings from theoretical and empirical research focused on minimizing the urban heat ...
Added: September 30, 2026
Dolgov A., МЕТОД: Московский ежегодник трудов из обществоведческих дисциплин 2025 Т. 5 № 4 С. 120–133
В обзоре интеллектуальное наследие В.И. Вернадского (1863-1945) рассматривается в контексте зарубежных инвайронментальных исследований (преимущественно на материале англоязычных публикаций двух последних десятилетий). Реконструируются ключевые идейные истоки мировоззрения Вернадского: влияние В.В. Докучаева, русского космизма и концепции ноосферы П. Тейяра де Шардена. Анализируются понятия научной системы Вернадского - «живое вещество», «биосфера» и «ноосфера»; прослеживается их рецепция в современных ...
Added: September 30, 2026
Курмаз С. В., Иванова И., Емельянова Н. С. et al., Mendeleev Communications 2023 Vol. 33 P. 255–258
Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH and NH3+ groups form hydrogen bonds. The compositions have lower cytotoxicity in ...
Added: September 14, 2025
Grigory Andreevich Puzanov, Scientific Reports 2022 Vol. 12 No. 1 Article 14588
Clear cell renal carcinoma has been reported in many research studies as a rather heterogeneous disease. Identification of different subtypes and their molecular characteristics can help in choosing a more effective treatment and predicting a response to it. In this study, using multi-omics clustering of RNA-Seq data of patients with clear cell renal carcinoma from ...
Added: September 23, 2022
Nersisyan S., Galatenko A. V., Ahlers A. et al., Biochimie 2022 Vol. 192 P. 91–101
In this study we analyzed expression of CD24 in a cohort of colorectal cancer patients using immunohistochemistry staining of CD24. We found a significant association between absence or low expression of CD24 (10% of membranous and 55% of cytoplasmic staining) and shortened patient survival. Protein localization played a crucial role in the prognosis: membranous form ...
Added: October 23, 2021
Knyazev E., Khristichenko A., Maltseva D. et al., Placenta 2019 Vol. 83 P. e59–e60
Objectives: The study of the transport and toxicity of xenobiotics in women is limited for ethical reasons. Ex vivo placenta models have high variability and low success rates. Animal models in vivo differ from a human in anatomy, genotype, and proteome. The placenta-on-a-chip model is a compromise. We studied the components of the FAC chemotherapy regimen for breast cancer in ...
Added: February 1, 2021
Knyazev E. N., Nikulin S. V., Khristichenko A. Y. et al., Russian Chemical Bulletin 2019 Vol. 68 No. 12 P. 2344–2349
An in vitro placental barrier model based on human choriocarcinoma BeWo b30 cell line was considered as a method of preclinical study of the transport and toxicity of antitumor agents and other organic compounds. Low permeabilities were found for 5-fluorouracil as an example of hydrophilic compound and for doxorubicin as an example of a lipophilic compound with ...
Added: February 1, 2021
Елисютина О. Г., Болдырева М. Н., Rebrova O. et al., Российский аллергологический журнал 2018 Т. 15 № 6 С. 33–44
The basis for the development of atopic dermatitis (AD) is genetic predisposition, hypersensitivity to allergens, Th1/Th2 disbalance, increased degranulation of mast cells and antigen-presenting activity of Langerhans cells, as well as epidermal barrier dysfunction. Recently, genotypes, phenotypes and endotypes of AD, and biomarkers, which can be used to assess the effectiveness of therapy and to ...
Added: October 23, 2019
Алексеева А. С., Волынский П. Е., Chugunov A. et al., Russian Journal of Bioorganic Chemistry 2018 Vol. 44 No. 6 P. 732–739
Preparation of liposomal formulations containing water-soluble drugs in the form of lipophilic
prodrugs in their lipid bilayer is of considerable interest. Previously, we synthesized doxorubicin dioleoyl
glyceride and oleoyl conjugates intended for incorporation into fluid-phase liposomal bilayers. In this work,
we studied the behavior of lipid conjugates in bilayers prepared from palmitoyl oleoyl phosphatidylcholine
and dimyristoyl phosphatidylcholine using methods ...
Added: February 25, 2019
Tonevitsky A., Kononenko O., Mityakina I. et al., Brain Research 2018 Vol. 1695 P. 78–83
The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with ...
Added: October 30, 2018
Александров Ю.И., Сварник О. Е., Знаменская И. И. et al., Вопросы психологии 2017 № 3 С. 80–91
Alcoholism as a cause of regression in learning and in pro-social behavior
Alexandrov Yu.I., Svarnik O.Ye., Znamenskaya I.I., Arutiunova K.R., Kolbeneva M.G., Krylov A.K., Bulava A.N.
Despite a long history of the notion of regression, its manifestations and mechanisms are still poorly researched, specific experimental studies are rare, points of view conflict. A study was conducted to discover dynamics of subjective experience and brain activity lying ...
Added: January 30, 2018
Глазунова В.А., Лобанов К. В., Шакулов Р. С. et al., Acta Naturae 2013 Т. 5 № 3 С. 78–82
We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter P-glycoprotein or lack of ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2012 Т. 10 № 8 С. 27–33
Исследованы характер экспрессии генов Prx 1, 2 и 6 при формировании лекарственной устойчивости опухолевых клеток к доксорубицину (DOX), цитотоксический эффект которого помимо интеркалирующего действия связан с активацией образования активных форм кислорода. Полученные данные свидетельствуют в пользу важной роли редокс-зависимого механизма формирования устойчивости опухолевых клеток к DOX. ...
Added: July 14, 2015