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Structural Features Of The Brain In Amnestic Mild Cognitive Impairment And Their Correlation With Mild Behavioral Impairment
Neuroscience and Behavioral Physiology. 2025. Vol. 55. No. 9. P. 1681–1687.
N. S. Cherkasov, Tomyshev A. S., Lebedeva I. S., Abdullina E. G., Bozhko O. V., Gavrilova S. I., Kolykhalov I. V.
Objective. To identify the structural features of the brain in elderly patients with amnestic mild cognitive impairment (aMCI) and the correlations of these features with mild behavioral impairment. Materials and methods. Fifty-three patients with aMCI (age 73.0 ± 8.5 years, nine men) and 34 mentally healthy subjects (66.8 ± 9.6 years, four men) were examined. Cognitive status was assessed using the Montreal Cognitive Assessment (MoCA) scale and the severity of mild behavioral impairment was evaluated using the MBI-C (Mild Behavioral Impairment Checklist) questionnaire. Structural MRI images were obtained on a 3T Philips Ingenia instrument. Cortical gray matter thickness, subcortical volumes, and their correlations with MBI-C and MoCA scores were analyzed. Results. Patients with aMCS were found to have smaller cortical thickness in the left superior frontal gyrus and right precuneus (p < 0.05), these parameters correlating negatively with MBI-C scores. In addition, this group had smaller amygdalar and hippocampal volumes in the left hemisphere (p < 0.05), with a positive correlation between the volume of the left amygdala and MoCA scores. Conclusion. The changes in structural MRI parameters and their correlations with neuropsychiatric and neurocognitive symptoms found here reflect the complex nature of the cerebral substrate of cognitive and behavioral impairments in aMCI. These results indicate the need for further work seeking clinically significant phenotypes in patients with aMCI, including those associated with an increased risk of Alzheimer’s disease.
Provlotskaya I., Minnigulova A., Gordeyeva E. et al., Brain Structure and Function 2026 Vol. 231 Article 113
The Wada test is an invasive procedure used to assess language and memory lateralization. Despite the widespread use of the Wada test in the population of people with epilepsy, the two existing standardized protocols for conducting the procedure are methodologically different and do not fully account for language comprehension as a separate domain. In this ...
Added: August 4, 2026
Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
Added: July 16, 2026
Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Minnigulova A., Dragoy O., Arutiunian V., European Child and Adolescent Psychiatry 2026
Communication deficits in Autism Spectrum Disorder (ASD) involve impairments in both verbal and nonverbal domains, potentially associated with altered brain network connectivity related to language, attention, and social cognition systems. This study investigated functional connectivity patterns among the Default Mode Network (DMN), Salience Network (SN), Dorsal Attention Network (DAN), and Language Network (LN) in male children ...
Added: June 18, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Lifshits A., Святохина Е. В., Одиссей: Человек в истории 2026 № 1 С. 156–173
This article introduces a new source for scholarly discussion on the history of Russian language, science, and culture in the late 17th century. Numerous Russian captions for engravings were discovered in a copy of the "Travnik" (Herbal) by the great Renaissance botanist and pharmacist Pietro Andrea Mattioli, published in Prague in German in 1563. In ...
Added: June 15, 2026
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Медицина 2026 Т. 14 № 2 С. 42–57
A global step in the fight against tobacco was the adoption of the WHO Framework Convention on Tobacco Control in 2003, which includes the organization of monitoring of the prevalence of tobacco consumption. The main condition for monitoring is its organization based on representative surveys of the population and its individual groups, as well as ...
Added: June 3, 2026
Mokienko O., Zisman M. A., Bobrov P. et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Gerges M., Evgenyeva E., Isakova D. et al., American Journal of Health Behavior 2026 Vol. 50 No. No.2, 2026 Article 2516
Objectives: Maladaptive eating behaviors characterize overeating disorders and are often accompanied by emotion dysregulation. Physiological mechanisms remain poorly understood. This study investigated psychophysiological responses to food-related, aversive, and neutral stimuli under different emotion regulation strategies.
Methods: Sixty-four adults (75% female; mean age = 45.6 years) with BMI ≥ 25 kg/m² participated (50 with overeating disorder, 14 ...
Added: April 28, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Cherkasov N., Rodionova E., Arina Zvereva et al., Applied Neuropsychology: Adult 2026 P. 1–11
Objective
Semantic and phonemic verbal fluency (VF) tasks are widely used to assess older adults’ cognition in clinical practice. Typical scoring only analyses the total number of correct words produced. We investigated whether differentiation between individuals with subjective cognitive decline (SCD) versus mild cognitive impairment (MCI), which is often challenging, could be enhanced by also assessing ...
Added: February 12, 2026
Cherkasov N., Томышев А. С., Лебедева И. С. et al., Журнал неврологии и психиатрии им. С.С. Корсакова 2025 Т. 125 № 6 С. 112–119
Objective. To determine structural brain features in elderly patients with amnestic mild cognitive impairment (aMCI) and to assess correlations between these features and mild behavioral impairment.
Materials and methods. The study included 53 patients with aMCI (age 73.0±8.5 years, 9 males) and 34 healthy controls (66.8±9.6 years, 4 males). Cognitive status was assessed using the Montreal ...
Added: July 1, 2025
Cherkasov N., Kolykhalov I., Neuroscience and Behavioral Physiology 2024 Vol. 54 No. 6 P. 845–851
Objectives. To assess the prevalence of mild behavioral impairment (MBI) syndrome in older people with mild cognitive impairment (MCI), to clarify the diagnostic criteria, and to characterize the neuropsychiatric symptoms identified.
Materials and methods. The study included 63 patients over 50 years of age (median 72 [68; 77] years) with MCI syndrome who underwent psychopathological and psychometric examination ...
Added: October 28, 2024
Cherkasov N., Колыхалов И. В., Журнал неврологии и психиатрии им. С.С. Корсакова 2024 Т. 124 № 4-2 С. 49–55
Objective. To assess the prevalence of mild behavioral impairment (MBI ) in elderly individuals with mild cognitive impairment (MCI ), refine diagnostic criteria, and characterize the identified neuropsychiatric symptoms.
Material and Methods. Sixty-three individuals over 50 years of age (median 72 [68; 77]) with MCI underwent psychiatric and psychometric assessments using clinical and psychopathological methods and ...
Added: May 3, 2024