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Transcriptomic Maps of Colorectal Liver Metastasis: Machine Learning of Gene Activation Patterns and Epigenetic Trajectories in Support of Precision Medicine
Cancers. 2023.
KUDRYAVTSEVA A.
Liver metastasis is a significant factor contributing to mortality associated with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for refining diagnostics and identifying therapeutic windows for interventions. Currently, little is known of the processes that govern the development of liver metastases, the role of the tumor microenvironment, the role of epigenetics, and potential treatment-induced shaping effects. Machine learning-based bioinformatics has provided an important methodical option to decipher fine-granular details of the transcriptomic landscape of tumor heterogeneity and the underlying molecular mechanisms. Our molecular portrayal method has potential implications for treatment decisions, which may require personalized diagnostics.
М.: Издательский дом НИУ ВШЭ, 2026.
В сборнике представлены отобранные оргкомитетом труды участников 17-й Международной научно-практической конференции студентов и аспирантов «Статистические методы анализа экономики и общества» из России, Армении, Беларуси и Китая, представляющих 27 вузов из 16 городов: Москва, Владивосток, Ереван, Йошкар-Ола, Минск, Новосибирск, Оренбург, Ростов-на-Дону, Санкт-Петербург, Саранск, Саратов, Севастополь, Уфа, Шахты, Шэньчжэнь, Электросталь.
Исследования посвящены вопросам статистической методологии, применению математико-статистических и ...
Added: October 21, 2026
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Gorbunov A. A., Исаев Е. А., Приборы и системы. Управление, контроль, диагностика 2026 № 1 С. 42–46
В статье рассматриваются современные тенденции в развитии дата-центров, специализирующихся на обработке биоинформатических и
биомедицинских данных. Особое внимание уделено применению искусственного интеллекта для оптимизации работы дата-центров и анализа больших объемов биологических данных. Представлен обзор современных технологий и архитектурных решений, позволяющих обрабатывать растущие объемы данных в области биоинформатики и биомедицины. Обсуждаются перспективы развития специализированных
дата-центров в контексте экспоненциального роста ...
Added: October 12, 2026
Gorbunov A. A., Григорьев А. А., Демидов Л. Н. et al., Приборы и системы. Управление, контроль, диагностика 2025 № 7 С. 20–24
Быстрое развитие технологии квантовых вычислений потенциально может произвести революцию в сложных вычислениях в
физических, химических и биологических областях за счет использования квантовой суперпозиции и запутанности. Квантовые компьютеры используют кубиты, способные существовать в нескольких состояниях одновременно, в отличие от классических битов.
Эта функция позволяет хранить и обрабатывать больше информации, что дает значительное преимущество при решении задач с
обширным пространством ...
Added: October 12, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Lin Z., Duan K., Wan R. et al., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Switzerland: Springer Cham, 2026.
This volume gathers selected, peer-reviewed contributions presented at the 19th Conference of the International Federation of Classification Societies (IFCS 2026), held on 14–16 July 2026 in Milan, Italy. Reflecting the volume’s motto, Navigating Complexity – Statistical Methods, Data Analysis, and Machine Learning for Actionable Insights, the papers showcase modern methodologies and real-world applications designed to extract ...
Added: September 25, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Ионцев М. А., Финансы и кредит 2025 Т. 31 № 12 С. 53–62
Предмет. Надзор за децентрализованными финансами. Цели. Поиск оптимальных условий для эффективного осуществления встроенного надзора за децентрализованными финансами. Методология. Использованы математические подходы, общенаучные и специальные методы научного познания: ретроспективный, системный и функционально-структурный анализ, классификация; инструментальные приемы сравнения и обобщения. Результаты. Рассмотрены основные проблемы экономического анализа встроенного надзора за децентрализованными финансами и пути решения этих проблем. Определены ...
Added: September 10, 2026
Manivelan S. V., Srinivasan S., Thamilmaran K. et al., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 No. 1 Article 014217
This study investigates the dynamical origins and statistical properties of extreme events (EEs) in a diffusively coupled theoretical Brusselator system, extending from pairwise interactions to globally coupled networks. Statistically, the emergence of EEs is characterized by heavy-tailed probability density functions and exponential interevent interval distributions, alongside an analysis of the complementary cumulative distribution function and ...
Added: July 15, 2026
Springer, 2026.
The book presents the proceedings of the 13th International Conference on Frontiers of Intelligent Computing: Theory and Applications (FICTA 2024), held at Intelligent Systems Research Group (ISRG), London Metropolitan University, London, United Kingdom, during June 6–7, 2025. Researchers, scientists, engineers and practitioners exchange new ideas and experiences in the domain of intelligent computing theories with ...
Added: June 8, 2026
Beknazarov N., , in: Parallel Computational Technologies, 19th International Conference, PCT 2025, Moscow, Russia, April 8–10, 2025, Revised Selected Papers. (CCIS, volume 2891)Vol. 2891.: Springer, 2026. P. 3–16.
This paper addresses the challenge of efficiently training Large Language Models (LLMs) on large-scale, sparse omics datasets in high-performance computing (HPC) environments. Using over 1000 BED tracks as a representative data source, we propose a method combining interval-based chunked storage, sparse matrix transformation, and parallel data loading, integrated within a PyTorch Lightning training framework. Our ...
Added: May 19, 2026
Neznanov A., Glushko A., Овчинников С. et al., В кн.: Интеллектуальный анализ данных в нефтегазовой отрасли.: М.: ООО «Геомодель Развитие», 2024. С. 140–143.
With the development of monitoring systems, now we have the opportunity to collect key performance indicators of devices in the process of artificial lift. Every day a huge amount of telemetry is generated by our devices, which can be used to forecast the working mode and health state of the equipment after the process of ...
Added: April 29, 2026