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Функциональная связанность в височных областях головного мозга и конверсия в болезнь Альцгеймера при мягком когнитивном снижении амнестического типа
Психиатрия. 2025. Т. 23. № 1. С. 6–17.
Паникратова Я. Р., Комарова А. Ю., Абдуллина Е. Г., Божко О. В., Cherkasov N., Гаврилова С. И., Колыхалов И. В., Лебедева И. С.
Background: structural and neurochemical abnormalities in temporal lobe and temporoparietal junction (T-TPJ) are seen not only in Alzheimer’s disease (AD) but also in amnestic mild cognitive impairment (aMCI). At the same time, studies of conversion to dementia focused on functional characteristics of these regions are lacking.
The aim was to search for patterns of functional connectivity (FC) within T-TPJ that differentiate patients with aMCI with future conversion to AD from stable aMCI patients and healthy controls.
Patients, Comparison Group and Methods: patients with aMCI who further converted to dementia due to AD (converters, n = 15), patients with stable aMCI (n = 12), and healthy individuals without cognitive deficits (n = 29) underwent resting-state functional magnetic resonance imaging. FC between cortical T-TPJ structures was compared between groups separately for each hemisphere (one-way ANCOVA and post hoc between-group comparisons).
Results: an increased FC between posterior parts of left middle and inferior temporal gyri was observed in converters compared to other groups. There was an inverse correlation between this FC and delayed recall of words (MoCA scale) in the entire sample, however, this correlation did not reach the level of statistical significance (p = 0.055).
Conclusions: the posterior parts of left middle and inferior temporal gyri are involved in auditory verbal memory and storing of visual images associated with a word, respectively. Therefore, а pattern of increased FC observed in future converters to AD may be a consequence of pathological processes that have already started and/or compensatory mechanisms.
Language:
Russian
Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
Added: July 16, 2026
Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
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Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
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Wang R., He Y., Myachykov A. et al., Neuroimage 2026 Vol. 332 Article 121926
Insomnia disorder (ID) exhibits considerable heterogeneity in neuroimaging findings across studies, and whether functional brain alterations are consistent across resting and task states remains unclear. This study aimed to identify neural dysfunction across states in ID and explore its transcriptomic correlates. ...
Added: July 13, 2026
Shestoperov A. I., Ivchenko A., Fomina E. V., Microgravity Science and Technology 2025 Vol. 37 Article 19
The paper is dedicated to the analysis of medico-biological data obtained during locomotor testing of astronauts. Accurate data interpretation plays a crucial role in locomotion system monitoring, prophylaxis of long-duration spaceflight negative effects and thus in the development of an autonomous medical support system for deep space expeditions. During the locomotor testing the astronaut changes ...
Added: June 26, 2026
Minnigulova A., Dragoy O., Arutiunian V., European Child and Adolescent Psychiatry 2026
Communication deficits in Autism Spectrum Disorder (ASD) involve impairments in both verbal and nonverbal domains, potentially associated with altered brain network connectivity related to language, attention, and social cognition systems. This study investigated functional connectivity patterns among the Default Mode Network (DMN), Salience Network (SN), Dorsal Attention Network (DAN), and Language Network (LN) in male children ...
Added: June 18, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Vasilev R., Savchenko A., Blinov P. et al., Frontiers in Medicine 2026 Vol. 13 Article 1778404
Automated disease screening systems face challenges when applied to multi-class medical image analysis, particularly under severe class imbalance inherent in clinical datasets. Retinal fundus imaging enables non-invasive screening for multiple ocular and systemic diseases simultaneously, yet current automated systems typically assess risk for only a single pathology or a limited disease range. We developed a ...
Added: June 16, 2026
Lifshits A., Святохина Е. В., Одиссей: Человек в истории 2026 № 1 С. 156–173
This article introduces a new source for scholarly discussion on the history of Russian language, science, and culture in the late 17th century. Numerous Russian captions for engravings were discovered in a copy of the "Travnik" (Herbal) by the great Renaissance botanist and pharmacist Pietro Andrea Mattioli, published in Prague in German in 1563. In ...
Added: June 15, 2026
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Медицина 2026 Т. 14 № 2 С. 42–57
A global step in the fight against tobacco was the adoption of the WHO Framework Convention on Tobacco Control in 2003, which includes the organization of monitoring of the prevalence of tobacco consumption. The main condition for monitoring is its organization based on representative surveys of the population and its individual groups, as well as ...
Added: June 3, 2026
Mokienko O., Zisman M. A., Bobrov P. et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
ЯКУБЕНКО Т. В., Plotnikov S., Ratio et Natura 2024 № 3 (11) Статья 10
The article presents the results of our own research aimed at studying the prospects of using genetic sequencing technologies to identify the risk of having children with genetic abnormalities. ...
Added: May 21, 2026
Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42
Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere.
Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...
Added: May 18, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110
Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...
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Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590
Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...
Added: April 15, 2026
Anna Pavlova, Adamovich T., Malykh S., Frontiers in Human Neuroscience 2026 Vol. 20 Article 1748183
The aim of the present study was to investigate the association between resting-state EEG functional connectivity and spatial working memory (SWM) in adolescents, using a graph-theoretical approach. Sixty-three healthy adolescents (38 females; M = 16.8, SD = 0.47) participated in the study. Resting-state EEG was recorded by a wireless dry-sensor 32-channel headset (Cognionics Quick-32r) configured in a standard 10–20 montage. ...
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Schoenmaekers C., Jillings S., Mortaheb S. et al., NPJ MICROGRAVITY 2025 Vol. 11 Article 71
Long-duration spaceflight affects otolith-mediated ocular counter-roll (OCR) and brain function, but the relationship between these changes is unclear. This study examines whether OCR changes correlate with functional connectivity (FC) changes in the vestibular network in the same cosmonauts after a long-duration (6-month) spaceflight mission. Using a human vestibular atlas, we found that changes in FC ...
Added: December 28, 2025
Vinogradova V., Manini B., Woll B. et al., Cerebral Cortex 2026 Vol. 36 No. 1 Article bhaf332
Our study investigates how language proficiency impacts cognitive processing in the brain. We focused on congenitally and early deaf adults, where individual differences in language access during development significantly influence language proficiency and cognitive function. This variability in language backgrounds and skills, allows us to explore the influence of early language experience on the large-scale ...
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