## Physics

The goal of this International Roadmap for Devices and Systems (IRDS) chapter is to survey, catalog, and assess the status of technologies in the areas of cryogenic electronics and quantum information processing. Application drivers are identified for sufficiently developed technologies and application needs are mapped as a function of time against projected capabilities to identify challenges requiring research and development effort. Cryogenic electronics (also referred to as low-temperature electronics or cold electronics) is defined by operation at cryogenic temperatures (below −150 °C or 123.15 K) and includes devices and circuits made from a variety of materials including insulators, conductors, semiconductors, superconductors, or topological materials. Existing and emerging applications are driving development of novel cryogenic electronic technologies. Information processing refers to the input, transmission, storage, manipulation or processing, and output of data. Information processing systems to accomplish a specific function, in general, require several different interactive layers of technology. A top-down list of these layers begins with the required application or system function, leading to system architecture, micro- or nano-architecture, circuits, devices, and materials. A fundamental unit of information (e.g., a bit) is represented by a computational state variable, for example, the position of a bead in the ancient abacus calculator or the voltage (or charge) state of a node capacitance in CMOS logic. A binary computational state variable serves as the foundation for von Neumann computational system architectures that dominated conventional computing. Quantum information processing is different in that it uses qubits, two-state quantum-mechanical systems that can be in coherent superpositions of both states at the same time, which can have computational advantages. Measurement of a qubit in a given basis causes it to collapse to one of the basis states. Technology categories covered in this report include: • Superconductor electronics (SCE) • Cryogenic semiconductor electronics (Cryo-Semi) • Quantum information processing (QIP)

This book brings together reviews by internationally renowed experts on quantum optics and photonics. It describes novel experiments at the limit of single photons, and presents advances in this emerging research area. It also includes reprints and historical descriptions of some of the first pioneering experiments at a single-photon level and nonlinear optics, performed before the inception of lasers and modern light detectors, often with the human eye serving as a single-photon detector. The book comprises 19 chapters, 10 of which describe modern quantum photonics results, including single-photon sources, direct measurement of the photon's spatial wave function, nonlinear interactions and non-classical light, nanophotonics for room-temperature single-photon sources, time-multiplexed methods for optical quantum information processing, the role of photon statistics in visual perception, light-by-light coherent control using metamaterials, nonlinear nanoplasmonics, nonlinear polarization optics, and ultrafast nonlinear optics in the mid-infrared.

This volume collects the referred papers based on plenary, invited, and oral talks, as well on the posters presented at the Third International Conference on Computer Simulations in Physics and beyond (CSP2018), which took place September 24-27, 2018 in Moscow. The Conference continues the tradition started by an inaugural conference in 2015. It took place on the campus of A.N. Tikhonov Moscow Institute of Electronics and Mathematics in Strogino, was jointly organized by the National Research University Higher School of Economics, the Landau Institute for Theoretical Physics and Science Center in Chernogolovka.

The Conference is a multidisciplinary meeting, with a focus on computational physics and related subjects. Indeed, methods of computational physics prove useful in a broad spectrum of research in multiple branches of natural sciences, and this volume provides a sample.

We hope that this volume will interest readers, and we are already looking forward to the next conference in the series.

Moscow, Russia

November, 2018

CSP2018 Conference Chair and Volume Editor

Lev Shchur

Computer simulations are nowadays a rmly established third pillar of modern natural sciences, complementing experimentation and paper-and-pencil theoret- ical studies. Simulations, experiments in silico, prove indispensable in diverse areas of research in physics and other natural sciences. This volume collects papers based on presentations delivered at the Sec- ond International Conference on Computer Simulations in Physics and beyond (CSP2017), which took place October 9-12, 2017 in Moscow. The Conference, which continues a biannual tradition started by an innaugural conference in 2015, took place on campus of A.N. Tikhonov Moscow Institute of Electronics and Mathematics, was jointly organized by the National Research University Higher School of Economics, the Landau Insitute for Theoretical Physics and Science Center in Chernogolovka. As the name implies, the Conference is a multidisciplinary meeting, with a focus on computational physics and related subjects. Indeed, methods of computational physics prove useful in a broad spectrum of research in multiple branches of natural sciences, and this volume provides a sample. We hope that this volume will interest a wide range of readers, and we are already looking forward for the next conference in this biannual series.

This book highlights selected topics of standard and modern theory of accretion onto black holes and magnetized neutron stars. The structure of stationary standard discs and non-stationary viscous processes in accretion discs are discussed to the highest degree of accuracy analytic theory can provide, including relativistic effects in flat and warped discs around black holes. A special chapter is dedicated to a new theory of subsonic settling accretion onto a rotating magnetized neutron star. The book also describes supercritical accretion in quasars and its manifestation in lensing events. Several chapters cover the underlying physics of viscosity in astrophysical discs with some important aspects of turbulent viscosity generation. The book is aimed at specialists as well as graduate students interested in the field of theoretical astrophysics.

The present book gathers chapters from colleagues of A. Ezersky from Russia, especially those from Nizhny Novgorod Institute of Applied Physics of the Russian Academy of Science and from France, with whom he has been collaborating on experimental and theoretical developments. The book is subdivided into two parts. Part I contains eight chapters related to nonlinear water waves and Part II addresses in five chapters, patterns dynamics in nonequilibrium media. The contributions of Alexander B. Ezersky were valuable from both the experimental and the theoretical points of view. We thank all the authors for their contributions and the Springer Editor for having kindly accepted the edition of this book in memory of our colleague and friend, Prof. Alexander Borisovich Ezersky.

The materials of The International Scientific – Practical Conference is presented below.

The Conference reflects the modern state of innovation in education, science, industry and social-economic sphere, from the standpoint of introducing new information technologies.

It is interesting for a wide range of researchers, teachers, graduate students and professionals in the field of innovation and information technologies.

These notes have appeared as a result of a one-term course in superfluidity and superconductivity given by the author to fourth-year undergraduate students and first-year graduate students of the Department of Physics, Moscow State University of Education. The goal was not to give a detailed picture of these two macroscopic quantum phenomena with an extensive coverage of the experimental background and all the modern developments, but rather to show how the knowledge of undergraduate quantum mechanics and statistical physics could be used to discuss the basic concepts and simple problems, and draw parallels between superconductivity and superfluidity.

Superconductivity and superfluidity are two phenomena where quantum mechanics, typically constrained to the microscopic realm, shows itself on the macroscopic level. Conceptually and mathematically, these phenomena are related very closely, and some results obtained for one can, with a few modifications, be immediately carried over to the other. However, the student of these notes should be aware of important differences between superconductivity and superfluidity that stem mainly from two facts: (1) electrons in a superconductor carry a charge, therefore one has to take into account interaction with electromagnetic radiation; (2) electrons move in a lattice, therefore phonons play a role not only a mediators of attractive interaction between pairs of electrons, but also as scatterers of charge carriers.

Although these are notes on superfluidity *and *superconductivity, and there are a few cross-references, the two subjects can be studied independently with, perhaps, a little extra work by the student to fill in the gaps resulting from such study. The material of Chapter 1 introduces the method of second quantisation that is commonly used to discuss systems with many interacting particles. It is then applied in Chaper 2 to treat the uniform weakly interacting Bose gas within the approach by N. Bogoliubov, and in Chapter 4 to formulate the theory of the uniform superconducting state put forth by J. Bardeen, L. Cooper and R. Schrieffer. Chapter 3 presents the theory proposed independently by E. Gross and L. Pitaevskii of a non-uniform weakly interacting Bose gas, with a discussion of vortices, rotation of the condensate, and the Bogoliubov equations. In Chapter 5 we discuss the Ginzburd-Landau theory of a non-uniform superconductor near the critical temperature and apply it to a few simple problems such as the surface energy of the boundary between a normal metal and a superconductor, critical current and critical magnetic field, and vortices.

In this paper we present the studies of an ultrametric mathematical model for protein operation and give them physical interpretations that extend the conventional view of ensymatic activity regulation. The model is based on a representation of a multidimentional rugged energy landscapes by a hierarchy of nested basins of local minima and an approximation of protein dynamics with an ultrametric random walk. In contrast to an ordinary random walk, the ultrametric random walk is more suitable for describing of multiscale conformational dynamics and it is consistent with the kinetic features of ligand binding. Using our ultrametric model we show different ways to regulate enzymatic activity.

Superconducting properties of metallic nanowires can be entirely different from those of bulk superconductors because of the dominating role played by thermal and quantum fluctuations of the order parameter. For superconducting channels with diameters below ∼ 50 nm fluctuations of the phase of the complex order parameter - the phase slippage - lead to non-zero resistance below the critical temperature. Fluctuations of the modulus of the complex order parameter broaden the gap edge of the quasiparticle energy spectrum and modify the density of states. In extreme case of very narrow channels imbedded in high-impedance environment (which fix the charge and, hence, enable strong fluctuations of the quantum-conjugated variable, the phase) the superconductor can be driven to insulating state – the Coulomb blockade. We review recent experimental activities in the field demonstrating rather unusual phenomena.

The materials of The International Scientific – Practical Conference is presented below. The Conference reflects the modern state of innovation in education, science, industry and social-economic sphere, from the standpoint of introducing new information technologies.

It is interesting for a wide range of researchers, teachers, graduate students and professionals in the field of innovation and information technologies.

The textbook is meant for students continuing to study English (levels B1-B2 according to the European Framework) and majoring in science. The exercises and tasks are aimed at developing speaking, writing and reading skills on the basis of authentic texts on the achievements of scientists rewarded the Nobel Prize in the years 2000-2014

Adequate assessment of individual functional motor potentials is important for developing appropriate rehabilitation strategies in ischemic stroke [1]. Microstructural changes in corticospinal tract (CST) and corpus callosum (CC) were repeatedly correlated to post-stroke outcome [2, 3]. However, relationship between them and functional recovery remains unclear. Here we investigated relationship between integrity of CST and CC assessed with diffusion tensor imaging (DTI) and brain functional state assessed with navigated transcranial magnetic stimulation (nTMS) in chronic ischemic supratentorial stroke.

In this volume we have collected papers based on the presentations given at the International Conference on Computer Simulations in Physics and beyond (CSP2015), held in Moscow, September 6-10, 2015. We hope that this volume will be helpful and scientifically interesting for readers.

The Conference was organized for the first time with the common efforts of the Moscow Institute for Electronics and Mathematics (MIEM) of the National Research University Higher School of Economics, the Landau Institute for Theoretical Physics, and the Science Center in Chernogolovka. The name of the Conference emphasizes the multidisciplinary nature of computational physics. Its methods are applied to the broad range of current research in science and society. The choice of venue was motivated by the multidisciplinary character of the MIEM. It is a former independent university, which has recently become the part of the National Research University Higher School of Economics.

The development of terahertz imaging instruments for security systems is on the cutting edge of terahertz technology. We are developing a THz imaging system based on a superconducting integrated receiver (SIR). An SIR is a new type of heterodyne receiver based on an SIS mixer integrated with a flux-flow oscillator (FFO) and a harmonic mixer which is used for phase-locking the FFO. Employing an SIR in an imaging system means building an entirely new instrument with many advantages compared to traditional systems. In this project we propose a prototype THz imaging system using an 1 pixel SIR and 2D scanner. At a local oscillator frequency of 500 GHz the best noise equivalent temperature difference (NETD) of the SIR is 10 mK at an integration time of 1 s and a detection bandwidth of 4 GHz. The scanner consists of two rotating flat mirrors placed in front of the antenna consisting of a spherical primary reflector and an aspherical secondary reflector. The diameter of the primary reflector is 0.3 m. The operating frequency of the imaging system is 600 GHz, the frame rate is 0.1 FPS, the scanning area is 0.5 × 0.5 m2, the image resolution is 50 × 50 pixels, the distance from an object to the scanner was 3 m. We have obtained THz images with a spatial resolution of 8 mm and a NETD of less than 2 K.

IVEC was originally created in 2000 by merging the U.S. Power Tubes Conferences and the European Space Agency TWTA Workshops. Now a fully international conference, IVEC is held every other year in the U.S., and in Europe and Asia alternately every fourth year. After the successful and enjoyable meeting in Paris, France in May, IVEC 2014 will return to its beautiful U.S. location in the city of Monterey.

We take a peek at a general program that associates vertex (or chiral) algebras to smooth 4-manifolds in such a way that operations on algebras mirror gluing operations on 4-manifolds and, furthermore, equivalent constructions of 4-manifolds give rise to equivalences (dualities) of the corresponding algebras.

The predictive properties of methods aimed for estimating the water content in skin from the spectral diffuse reflection characteristics near the water absorption line in the near-IR spectral range are analysed. Numerical simulation data, experimental data on diffuse reflection from human skin phantoms, and data from the reference data set of human skin reflectance spectra are used to consider the possibility of gaining additional information about the water distribution in skin. The influence of variations in the scattering coefficient and oxyhaemoglobin concentration on the water content estimates is investigated.

Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subunits, binds biotinylated α-bungarotoxin (αBgt) with nanomolar affinity and might be a protection against snake-bites. Since there are no data on HAP interaction with other toxins, we checked its binding of α-cobratoxin (αCtx), similar to αBgt in action on nAChRs. Using radioiodinated αBgt, we confirmed a high affinity of HAP for αBgt, the complex formation is supported by mass spectrometry and gel chromatography, but only weak binding was registered with αCtx. A combination of protein intrinsic fluorescence measurements with the principal component analysis of the spectra allowed us to measure the HAP-αBgt binding constant directly (29 nM). These methods also confirmed weak HAP interaction with αCtx (>10000 nM). We attempted to enhance it by modification of HAP structure relying on the known structures of α-neurotoxins with various targets and applying molecular dynamics. A series of HAP analogues have been synthesized, HAP[L9E] analogue being considerably more potent than HAP in αCtx binding (7000 nM). The proposed combination of experimental and computational approaches appears promising for analysis of various peptide-protein interactions.

We establish a remarkable relationship between the quantum Gaudin models with boundary and the classical many-body integrable systems of Calogero-Moser type associated with the root systems of classical Lie algebras (B, C and D). We show that under identification of spectra of the Gaudin Hamiltonians H^G_j with particles velocities \dot{q}_j of the classical model all integrals of motion of the latter take zero values. This is the generalization of the quantum-classical duality observed earlier for Gaudin models with periodic boundary conditions and Calogero-Moser models associated with the root system of the type A.

NaCl is one of the simplest compounds and was thought to be well-understood, and yet, unexpected complexities related to it were uncovered at high pressure and in low-dimensional states. Here, exotic hexagonal NaCl thin films on the (110) diamond surface were crystallized in the experiment following a theoretical prediction based on *ab initio* evolutionary algorithm USPEX. State-of-the-art calculations and experiments showed the existence of a hexagonal NaCl thin film, which is due to the strong chemical interaction of the NaCl film with the diamond substrate.

We develop an axisymmetric numerical MHD model that allows us to investigate the spatial characteristics of the interplanetary magnetic field (IMF) and key solar wind plasma parameters from 20 to 400 solar radii over all heliolatitudes. The study is aimed at an analysis of the evolution of the spatial structure of the heliosphere through the solar cycle. We consider various combinations of the relative input of the quadrupole and dipole harmonics of the solar magnetic field to imitate the solar cycle. Self-consistent solutions for the IMF, electric current, solar wind speed, density, thermal pressure, and temperature in the solar wind are obtained. The spatial evolution of the IMF and properties of quasi-stationary current sheets (QCSs) are analyzed during different phases of the solar cycle. It is shown that a classic low-latitude heliospheric current sheet is formed in the solar wind as a part of the system of longitudinal and latitudinal electric currents symmetric in the northern and southern hemispheres only during solar minimum. While the quadrupole magnetic field increases, the second QCS appears. The model successfully describes a smooth transition from the state of the fast solar wind at high heliolatitudes and the slow solar wind at low heliolatitudes at solar minimum to the solar wind speed of the same values in a wide range of heliolatitudes at solar maximum. It reproduces the actively debated phenomenon of the south–north asymmetry of the IMF in the heliosphere and shows the distribution of thermal plasma parameters consistent with observations.