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Regular version of the site

Book chapter

Searching for electrophysiological endophenotypes of antisocial personality disorder: ERP and ERBP traits in visual Go/No Go and auditory oddball tasks

P. 301-301.
Varlamov A., Duggan C., Strelets V., Kravchenko A., Howard R., Liddle P.
The search for electrophysiological correlates of antisocial personality is currently focused on event-related brain activity changes recorded in a variety of experimental paradigms. Whule the data on ERP changes are quite comprehensive, research on induced EEF changes (non phase locked activity) is very scarce. The aim of the present study was to explore the possibilities of combined analysis pf ERPs and induced changes of oscillatory EEG activity related to antisocial personality and increased impulsivity. Psychopatic patients revealed decreased early negative ERP component N100 over frontolateral areas in response to negative feedback. A significantly reduced amplitude of early prefrontal negative ERP components for target/nontarget stimuli was found in both tasks. Ad for the induced changes, the psychopaths were characterized by reduced stimulus-related increase in delta and theta bands over frontal areas irrespective of stimulus type, stemming mostly from elevated slow oscillatory background activity. The data provide an additional evidence of general dysfunction of prefrontal cortex in psychopaty, while hypoactivation of posterior cortex was more selective and probably reflects decrease of sensitivity to positive feedback. The relative independence of candidare EEG endophenotypes of psychopathy points to a conclusion that a multivariative measure based on different EEG traits will have a much stronger predictive power than any single EEG feature.