?
Терапия внеклеточными везикулами: возможности, механизмы и перспективы применения
Российский кардиологический журнал. 2020. Т. 25. № 10. С. 221–231.
Velikonivtsev F., Головкин А. С.
Extracellular vesicles are biological membrane-coated objects with size less then 1000 nm. They can contain variety of biologically active molecules (such as proteins, miRNA, mRNA, DNA etc.) and also are able to provide intercellular communications and implement lots if biological functions. Now possibilities of using extracellular vesicles for therapeutic approaches against various diseases and pathological conditions are rapidly discovered. In the most of cases mesenchymal stem cells are the sources of extracellular vesicles and miRNAs which vesicles transport are considered to be causable agents of their activities. In-vitro studies show that extracellular vesicles provide anti-inflammatory, anti-apoptotic activities and can stimulate angiogenesis and regeneration. Performed studies which were analyzed and structurized by us in this review demonstrate current perspectives for clinical use of extracellular vesicles in the therapy of such clinical conditions as oxidative stress, ischemia-reperfusion injury, tumor growth etc.
Myachin A. L., Procedia Computer Science 2026 Vol. 287 P. 193–200
We extend the static pattern analysis method to the temporal dimension by introducing a six-type trajectory taxonomy that classifies objects according to the frequency and structure of pattern switches over an observation window of T > 8 periods. For each object, a reference pattern is designated as the most frequently occupied group over the observation ...
Added: September 18, 2026
Громов Р. С., Нестеров Р.А., Proceedings of the Institute for System Programming of the RAS 2026 Vol. 38 No. 4 P. 23–44
This paper explores the performance criteria of the newest algorithm for solving the problem of finding shortest paths on a graph from a given vertex – Bounded Multi-Source Shortest Path Algorithm
(BM-SSP). The algorithm was published in 2025 and, as its creators claim, it is asymptotically superior to Dijkstra’s deterministic algorithm. However, in the publication devoted ...
Added: September 18, 2026
Shaitan A., Ke Y., Shutao C. et al., BMC Biology 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Rogachev A.O., Sysoeva O. V., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Кузнецов М. Е., Полякова М., Лукьянович В. et al., ФАНУ "Востокгосплан", 2026.
Обзор международных практик развития робототехники и искусственного интеллекта и оценка возможностей их применения в условиях России, в первую очередь для Дальнего Востока и Арктической зоны РФ ...
Added: September 16, 2026
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Melman A., Evsyutin O., Computer Science Review 2027 Vol. 63 (A) Article 101066
One of the effective means of protecting digital images is invisible watermarking. Different scenarios have different requirements for watermark resistance to post-processing. Robust watermarking schemes are resistant to a wide range of modifications. Fragile watermarking schemes are designed for integrity control and are destroyed by even minor modifications of images. Semi-fragile watermarking schemes combine features ...
Added: September 15, 2026
Воронова К. Д., Lyadova L. N., Proceedings of the Institute for System Programming of the RAS 2026 Vol. 38 No. 4 P. 153–170
Title: Automated Event Logs Generation Based on Unstructured Internet Sources for Process Analysis Tasks
Abstract. This paper presents an approach to automated structuring event-related information extracted from unstructured textual Internet sources for process mining tasks. In many practical cases, information on events associated with various processes is not presented in the form of ready-made event logs, but is ...
Added: September 14, 2026
Springer, 2026.
This book gathers selected papers from the KES-IDT 2025 conference, held in Solin, Croatia, on June 25–27, 2025. The book presents and discusses the latest research results and generates new ideas in the field of intelligent decision-making. The range of topics discussed is classification, prediction, data analysis, big data, data science, decision support, knowledge engineering, ...
Added: September 13, 2026
Lebedev O. B., Митяков Е. С., Саенко И. Б. et al., Информация и космос 2026 № 1 С. 53–58
The article presents a methodology for the integrated assessment of cyberattacks on industrial control systems (ICS) using a combination of the Ampire cyber range and a digital twin. The approach is based on calculating five criteria—severity, attacker capabilities, vulnerability, complexity, and defense effectiveness—that form an integrated threat index. Testing across three scenarios confirmed the index's ...
Added: September 13, 2026
Lebedev O. B., Лебедев Б. К., Бесхмельнов М. И., Известия ЮФУ. Технические науки 2024 № 2(242) С. 177–190
This article examines algorithms for generating motion trajectories for unmanned aerial vehicles (UAVs) during search-and-rescue and emergency response operations. It describes methods and algorithms for controlling the movement of a UAV group in various formations—such as line, rank, column, and during turns. Control is achieved through alternative collective adaptation algorithms based on principles of collective ...
Added: September 13, 2026
Lebedev O. B., Котов Д. В., Известия ЮФУ. Технические науки 2024 № 1(237) С. 155–167
The primary approach to solving motion planning and control problems involves the use of intelligent technologies. These technologies are applied to define and adjust control objectives and action programs, as well as to formulate control algorithms under conditions of uncertainty—stemming from various factors—across actuator elements and the motion control, planning, and behavioral subsystems. This paper ...
Added: September 13, 2026
Гибридный алгоритм оптимизации на основе объединения моделей роевого интеллекта: роя хромосом и пчел
Lebedev O. B., Лебедев Б. К., Ганжур М. А., Информатизация и связь 2023 № 2 С. 80–84
A hybrid algorithm has been developed to solve the VLSI component placement problem by combining procedures based on bee colony behavior and a chromosome swarm. The optimization criterion is based on estimates of the number of nets crossing specific lines within the routing area. A modified chromosome swarm paradigm is described; unlike the canonical method, ...
Added: September 13, 2026
Lebedev O. B., Лебедев Б. К., Бесхмельнов М. И., Вестник Тверского государственного технического университета 2025 № 3(27) С. 103–119
The article presents a detailed analysis of a hybrid path-planning algorithm designed for navigation in a two-dimensional space, accounting for partial uncertainty regarding terrain information. The algorithm operates in stages and is divided into two levels. At the first level, the object's local visibility zone is established, and the corresponding region on the map is ...
Added: September 12, 2026
Lebedev O. B., Лебедев Б. К., Бесхмельнов М. И., Известия ЮФУ. Технические науки 2025 Т. 2(244) С. 68–82
This paper describes a hybrid situational trajectory planning algorithm for 2D space operating under conditions of partial uncertainty. Based on the integration of wave-propagation and ant colony optimization algorithms, it enables the real-time generation of minimum-length trajectories while simultaneously optimizing other path quality criteria. The processes of generating a trajectory segment and moving the object ...
Added: September 12, 2026
Lebedev O. B., Beskhielnov M. I., OPTIMIZATION BY THE SWARM OF TRANSFORMING CHROMOSOMES METHOD 2024 Vol. 34 No. 3 P. 652–658
A new strategy for finding effective solutions based on modification and hybridization of the canonical representations of the particle swarm algorithm is proposed. A paradigm of a swarm of transforming chromosomes is described, making it possible to represent solutions in the affine space of chromosomes with integer parameter values. The mechanisms of chromosome transformation in ...
Added: September 12, 2026
Lebedev O. B., Левченко Д. Д., Черкасов Р. И., Инженерный вестник Дона 2026 № 2(134) Статья 7
This article analyzes the impact of artificial intelligence (AI) and machine learning technologies on the development and transformation of cyberthreats and the creation of highly effective cyberdefense systems. Key trends in AI evolution are discussed, including data-, model-, application-, and human-centric approaches, and their role in shaping both defensive and offensive capabilities. It is shown ...
Added: September 12, 2026
Marinin N., Getman A., Труды Института системного программирования РАН 2026 Т. 38 № 4 С. 123–142
This paper investigates a method for detecting DNS tunnels in network traffic using a neural network.
To achieve this, an analysis of current detection approaches was conducted, and a dataset for neural network
training was prepared. The proposed model takes as input a sequence of characters extracted from DNS
responses. The trained model demonstrated an F1-score close to ...
Added: September 11, 2026
Савченко В. В., Savchenko L., Измерительная техника 2026 Т. 75 № 3 С. 105–113
Within the framework of a current area of research in the field of speech acoustics – non-invasive analysis of speech
production processes – the acute problem of insufficient accuracy of parametric methods for coding a turbulent (noise) type voice source is considered. In order to overcome this problem, a method for coding a sound source with increased ...
Added: September 11, 2026
Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12
Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...
Added: December 22, 2025
Семенова Н. В., Райгородская М. П., Averinskaya D. et al., Бюллетень экспериментальной биологии и медицины 2025 Т. 180 № 7 С. 114–118
The microRNA profile in the blood plasma of menopausal women with insomnia (according to the Pittsburgh Sleep Quality Index questionnaire) was studied in two stages with 15 participants in each and an interval of 12 months. Both stages involved 12 women, and no transition from one group to another was detected in the second stage ...
Added: September 5, 2025
Shkurnikov M., Darya Averinskaya, Stekolshchikova E. et al., Biochimie 2024 Vol. 227 P. 77–85
Breast cancer recurrence is associated with the growth of disseminated cancer cells that separate from the primary tumor before surgical treatment and hormonal therapy and form a metastatic niche in distant organs. We previously demonstrated that IGFBP6 expression is associated with the risk of early relapse of luminal breast cancer. Knockdown of IGFBP6 in MDA-MB-231 breast cancer ...
Added: August 14, 2024
Долотказин Д. Р., Аверинская Д. А., Князев Е. Н. et al., Онкоурология 2024 Т. 20 № 1 С. 36–43
Background. Limited sensitivity and specificity of existing prostate cancer (PCa) diagnosis methods drive the search for new markers. A number of studies has demonstrated the potential for measuring expression of certain microRNAs in urine.
Aim. To evaluate the diagnostic potential of measuring microRNA expression in urine in PCa.
Materials and methods. A collection of urine sediment samples from 19 patients ...
Added: May 27, 2024