Применение методов обработки изображений в компьютерной биологии
System of image processing of undermost biological object, to permit calculate their geometric parameters in process of morphogenesis was designed. We propose criterion on which base it is possible to calculate velocities of regenerations of the lost parts from ?at worms-planaria.
We study the stability conditions of the multiserver system in which each customer requires a random number of servers simultaneously. The input flow is supposed to be a regenerative one and a random service time is identical at all occupied servers. The service time has an exponential or a phase-type distribution. We define an auxiliary service process that is the number of served customers under assumption that always there are customers at the system. Then we construct the sequence of common regeneration points for the regenerative input flow and the auxiliary service process. Basing on relation between the real and auxiliary service processes we obtain the upper and lower estimates for the mean of the really served customers during the common regeneration period. It allows us to deduce the stability criterion of the model under consideration. It turns out that the stability condition does not depend on the structure of the input flow, only the rate of this process plays a role. Nevertheless the distribution of the service time is a very important factor. We give an example which shows that the stability condition can not be expressed in terms of the mean of the service time.
In the paper we present a new notion of stochastic monotone measure and its application to image processing. By definition, a stochastic monotone measure is a random value with values in the set of monotone measures and it can describe a choice of random features in image processing. In this case, a monotone measure describes uncertainty in the problem of choosing the set of features with the highest value of informativeness and its stochastic behavior is explained by a noise that can corrupt images.
On the basis of the signature analysis it is entered various concepts: the sample containing information and procedural parts and contour function. The identification methodology graphic objects invariant to affine transformations on the basis of concept of contour function is stated.
We report the first experimental evidence for the mitogenic action of cerium(IV) oxide and cerium(III) fluoride nanoparticles (CONs and CFNs) on the regeneration of a whole organism – freshwater flatworms Schmidtea mediterranea (planarian). Both types of cerium-containing nanoparticles are shown to be a highly potent mitogen for planaria. Both CONs and CFNs, in micro- and nanomolar concentrations, markedly accelerate planarian blastema growth, due to the enhancement of cellular proliferation, causing an increase in the mitotic index and in the quantity of blastema cells in regenerating planaria. CONs provided maximum activity at concentrations which were two orders of magnitude lower than those for CeF3. The valence state of cerium in cerium-containing nanoparticles plays a significant role in the planarian regeneration mechanism: CeO2 nanoparticles containing predominantly Ce4+ species presumably scavenge wound induced reactive oxygen species and moderately activate gene expression processes, while the regenerative action of CeF3 nanoparticles containing only Ce3+ species is manifested in the pronounced expression of the genes involved in cell division, differentiation and migration. This is the first report on the effect of cerium-containing nanoparticles on tissue regeneration in vivo, further revealing the mechanisms of their biological action, which enhances the possibility of their use in cellular technologies.
This paper reviews the fundamental statements of Rene Thom's (1923 – 2002) theory of morphogenesis. This theory is also known as a «theory of catastrophes», based on reinterpretation of Aristotle's concept of form, which is founded on research of fundamental characteristics of geometrically described space comprehended as a substance (hyle) of things, theoretical biology and phenomenology.
This book constitutes the refereed proceedings of the 12th Industrial Conference on Data Mining, ICDM 2012, held in Berlin, Germany in July 2012. The 22 revised full papers presented were carefully reviewed and selected from 97 submissions. The papers are organized in topical sections on data mining in medicine and biology; data mining for energy industry; data mining in traffic and logistic; data mining in telecommunication; data mining in engineering; theory in data mining; theory in data mining: clustering; theory in data mining: association rule mining and decision rule mining.
A model for organizing cargo transportation between two node stations connected by a railway line which contains a certain number of intermediate stations is considered. The movement of cargo is in one direction. Such a situation may occur, for example, if one of the node stations is located in a region which produce raw material for manufacturing industry located in another region, and there is another node station. The organization of freight traﬃc is performed by means of a number of technologies. These technologies determine the rules for taking on cargo at the initial node station, the rules of interaction between neighboring stations, as well as the rule of distribution of cargo to the ﬁnal node stations. The process of cargo transportation is followed by the set rule of control. For such a model, one must determine possible modes of cargo transportation and describe their properties. This model is described by a ﬁnite-dimensional system of diﬀerential equations with nonlocal linear restrictions. The class of the solution satisfying nonlocal linear restrictions is extremely narrow. It results in the need for the “correct” extension of solutions of a system of diﬀerential equations to a class of quasi-solutions having the distinctive feature of gaps in a countable number of points. It was possible numerically using the Runge–Kutta method of the fourth order to build these quasi-solutions and determine their rate of growth. Let us note that in the technical plan the main complexity consisted in obtaining quasi-solutions satisfying the nonlocal linear restrictions. Furthermore, we investigated the dependence of quasi-solutions and, in particular, sizes of gaps (jumps) of solutions on a number of parameters of the model characterizing a rule of control, technologies for transportation of cargo and intensity of giving of cargo on a node station.
Event logs collected by modern information and technical systems usually contain enough data for automated process models discovery. A variety of algorithms was developed for process models discovery, conformance checking, log to model alignment, comparison of process models, etc., nevertheless a quick analysis of ad-hoc selected parts of a journal still have not get a full-fledged implementation. This paper describes an ROLAP-based method of multidimensional event logs storage for process mining. The result of the analysis of the journal is visualized as directed graph representing the union of all possible event sequences, ranked by their occurrence probability. Our implementation allows the analyst to discover process models for sublogs defined by ad-hoc selection of criteria and value of occurrence probability
Existing approaches suggest that IT strategy should be a reflection of business strategy. However, actually organisations do not often follow business strategy even if it is formally declared. In these conditions, IT strategy can be viewed not as a plan, but as an organisational shared view on the role of information systems. This approach generally reflects only a top-down perspective of IT strategy. So, it can be supplemented by a strategic behaviour pattern (i.e., more or less standard response to a changes that is formed as result of previous experience) to implement bottom-up approach. Two components that can help to establish effective reaction regarding new initiatives in IT are proposed here: model of IT-related decision making, and efficiency measurement metric to estimate maturity of business processes and appropriate IT. Usage of proposed tools is demonstrated in practical cases.