From common rocks to valuable industrial resources: Limestone in nineteenth-century Russia
Focusing on the accelerated use of limestone as a building material in Russia, and government sponsored scientific studies of widespread limestone deposits throughout the nineteenth-century, this contribution investigates the process of transforming common rocks into measurable and valuable natural resources indispensable for actualizing industrial development on a national scale. Special attention is given to the production of a new body of expert knowledge on the specific properties, qualities and practical uses of raw stone materials, to the actors involved in producing this knowledge, and to their crucial role in forming a scientific support system for the mining and construction industries, which gradually developed an institutional hierarchy in its own right. One of the important points of the article is, on the one hand, to show that scientific engagement with the material was closely interrelated to ‘resource nationalism’ policies that became an influential driving force of material sciences institutionalization on the national scale. On the other hand, it is argued that the international circulation of knowledge, technics, and standardization of testing procedures also greatly influenced that process.
The chapter analyzes the history of using and understanding the notion of "property" in Russian political thought of the nineteenth century
Shroud of Mary of Tver, the famous monument of Old Russian art? 14 st., was comissioned in honor of important political event, reconsiliation among the princes of Moscow Dom in 1389-1390.
The significance of memoir complex associated with the large Russian historians of the XX century, as an important historical source.
One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been improved algorithms for utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.
Papers about natural protection territories
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
Neuronal nicotinic acetylcholine receptors (NNRs) of the α7 subtype have been shown to contribute to the release of dopamine in the nucleus accumbens. The site of action and the underlying mechanism, however, are unclear. Here we applied a circuit modeling approach, supported by electrochemical in vivo recordings, to clarify this issue. Modeling revealed two potential mechanisms for the drop in accumbal dopamine efflux evoked by the selective α7 partial agonist TC-7020. TC-7020 could desensitize α7 NNRs located predominantly on dopamine neurons or glutamatergic afferents to them or, alternatively, activate α7 NNRs located on the glutamatergic afferents to GABAergic interneurons in the ventral tegmental area. Only the model based on desensitization, however, was able to explain the neutralizing effect of coapplied PNU-120596, a positive allosteric modulator. According to our results, the most likely sites of action are the preterminal α7 NNRs controlling glutamate release from cortical afferents to the nucleus accumbens. These findings offer a rationale for the further investigation of α7 NNR agonists as therapy for diseases associated with enhanced mesolimbic dopaminergic tone, such as schizophrenia and addiction