The article deals with migration issues in the border regions of Siberia and the Far East. It was found that the main factor in the decline in the population in these regions was the domestic migration outflow of the population, mainly to the central and southern regions of Russia. It was revealed that international labor migration as a whole has a positive impact on the economy of the border regions. Based on the system of statistical indicators, the index of migration attractiveness of the border regions of Siberia and the Far East was calculated. According to the migration statistics, indices of migration substitution depth were calculated in the regions under consideration.
The comparison of the Kaluga and Nizhny Novgorod provinces shows that cluster formation represents a technological instrument of federal policy toward regions. To a degree it is a return to the economic branch approach at the new stage of growth. In the framework of cluster development regulation most Russian regions face the task of remaining within a cluster because it guarantees federal support.