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Post-translational modifications of FDA-approved plasma biomarkers in glioblastoma samples
Plos One. 2017. Vol. 12. No. 5. P. 0177427-1–0177427-21.
Petushkova N., Zgoda V., Pyatnitskiy M., Larina O., Teryaeva N., Potapov A., Lisitsa A.
Liquid chromatography-tandem mass spectrometry was used to analyze plasma proteins of volunteers (control) and patients with glioblastoma multiform (GBM). A database search was pre-set with a variable post-translational modification (PTM): phosphorylation, acetylation or ubiquitination. There were no significant differences between the control and the GBM groups regarding the number of protein identifications, sequence coverage or number of PTMs. However, in GBM plasma, we unambiguously observed a decreased fraction in post-translationally modified peptides identified with high quality. The disease-specific PTM patterns were extracted and mapped to the set of FDA-approved plasma protein markers. Decreases of 46% and 24% in the number of acetylated and ubiquitinated peptides, respectively, were observed in the GBM samples. Significance of capturing disease-associated patterns of protein modifications was envisaged.
Mysin I. E., Dubrovin S. V., Cognitive Neurodynamics 2026 Vol. 20 No. 191 P. 1–30
The hippocampal theta rhythm is crucial for memory and navigation. It is paced by parvalbumin-expressing GABAergic neurons in the medial septum. These neurons segregate into two subpopulations—Teevra and Komal cells—which fire in anti-phase bursts at theta frequency, with a stable phase shift of approximately 150 degrees, and exhibit mutual inhibition. While essential, the network mechanism ...
Added: November 14, 2026
Мысин И. Е., Журнал высшей нервной деятельности им. И.П. Павлова 2024 Т. 74 № 5 С. 517–537
Information in the brain is encoded by large populations of neurons, i.e., neural ensembles. Place cells in hippocampal the CA1 field have become an experimental model for studying neural ensembles in the brain, as they provide a convenient research system. This review addresses the latest research on place cells in the CA1 field. The principles ...
Added: November 13, 2026
Колодеева Ок. Е., Колодеева Ол. Е., Razumovskaya A. et al., Доклады российской академии наук. Науки о жизни 2026 Т. 530 № 1 С. 614–620
Targeted delivery of therapeutic agents using lipid vesicles is an important area of modern biomedicine. However, the intrinsic biological effects of such carriers on cells require further investigation. Nanoarchaeosomes represent one promising class of delivery vehicles. In the present study, we investigated the response of Caco-2 intestinal epithelial cells to unloaded nanoarchaeosomes. Their exposure was ...
Added: November 13, 2026
Popkova D., Menshov A., Sintsova O. et al., International Journal of Biological Macromolecules (Нидерланды) 2026 Vol. 376 No. 1 P. 1–19
Reducing polysaccharide degradation through inhibition of α-amylases and α-glucosidases is one of the strategies
for glycemic control in the treatment of diabetes mellitus. Here we report the identification and characterization
of a new β-defensin-like miniprotein magnificamide-2 (Mgf-2), one of the most potent inhibitors of mammalian
α-amylases with subnanomolar binding affinity (Ki of recombinant Mgf-2 is 0.029 nM against ...
Added: November 7, 2026
Bagaeva D. I., Demina G. R., Panina I. S. et al., International Journal of Biological Macromolecules (Нидерланды) 2026 Vol. 358 No. 1 P. 1–19
It was shown previously that mycobacteria (Mycobacterium smegmatis and Mycobacterium tuberculosis) accumulate
tetramethyl ether of coproporphyrin III (TMC) during transition to dormant state. However, the enzymes
involved in TMC synthesis remained unknown. Here we have identified a new M. smegmatis methyltransferase
MSMEG_0614 (CPmtA) that catalyzes the S-adenosyl-L-methionine-dependent conversion of coproporphyrin
(CP) into TMC through sequential methylation of its carboxyl ...
Added: November 7, 2026
Neuberger A., Veretenenko I. I., Shalygin A. et al., Nature Communications 2026 Vol. 17 No. 1 P. 1–13
Polyamines are organic cations that are present at sub-millimolar concentrations
in the cytoplasm and extracellular fluids and serve as versatile modulators
of TRP channels, fine-tuning their functions in physiological and
pathological contexts, including pain, inflammation and cancer. Despite
extensive functional studies, the structural basis by which polyamines regulate
TRP channels remains unclear. Here, we combine calcium imaging, electrophysiology,
cryo-electron microscopy, mutagenesis ...
Added: November 7, 2026
Neuberger A., Shalygin A., Veretenenko I. I. et al., Nature Communications 2025 Vol. 16 No. 1 P. 1–16
TRPV6 is a member of the vanilloid subfamily of transient receptor potential
channels, which serves as the master regulator of Ca2+ homeostasis. TRPV6
functions as a constitutively active Ca2+ channel, and emerging evidence
indicates that its overactivity underpins the progression of several human
diseases, including cancer. Hence, there is a pressing need to identify TRPV6
inhibitors in conjunction with a ...
Added: November 7, 2026
Gubin D., Danilova L., Kolomeichuk S. et al., Chronobiology International 2026 P. 1–12
University students often experience circadian misalignment with academic schedules, which may
impair performance. This study evaluated whether a later-start schedule improves academic outcomes
and circadian rhythms in first-year medical students. Incoming students (n = 220) completed
the Munich Chronotype Questionnaire; those with high social jetlag (SJL >120 min, n = 71)
were randomized into either a later-start schedule (LS; ...
Added: November 5, 2026
Poddiakov A., Integrative Psychological and Behavioral Science 2026 Vol. 60 No. 4 P. 1–50
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, and “ability to engage with not-knowing” (de Freitas) is also a crucially important source of scientific creativity. Starting from studies by C. S. Peirce and B. Russell, scientists have developed tools for working with increasingly accurate ...
Added: November 3, 2026
Zubov A., Zubov A., Малявко, Я. et al., Computer Physics Communications 2025 Vol. 317 Article 109860
The concept of representative volume (REV, or RVE in material sciences) is the cornerstone of continuum scale models – one needs to get the volume big enough so that it could be represented with an averaged value (scalar, vector or tensorial, etc.). While REV should be established in all larger scale simulations, this is rarely ...
Added: October 28, 2026
Четверикова М. М., Потемкин А. Н., Stepanova E., Бюллетень экспериментальной биологии и медицины 2026 Т. 182 № 9 С. 242–247
Gemcitabine, a first-line chemotherapeutic agent for bladder cancer (BC), often loses clinical efficacy due to the development of drug resistance, the underlying mechanisms of which remain poorly understood. In this work, a highly gemcitabine-resistant RT112/GR cell line was obtained by long-term selection. The MTT assay revealed a 9312-fold decrease in gemcitabine sensitivity and moderate resistance to cisplatin (2.60-fold, p ...
Added: October 26, 2026
Maltseva D., Tonevitsky A., Frontiers in Molecular Biosciences 2026 Vol. 13 P. 1–28
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate at varying levels and exhibit distinct tissue-specific expression patterns, indicating the presence of regulatory ...
Added: October 23, 2026
Vasilyev A., Svirin EP, Dubynin I. et al., Cortex 2025 Vol. 189 P. 76–96
Added: October 22, 2026
Karina V. Klycheva, Mariia O. Silkina, Dmitry M. Hushpulian et al., Biochemistry. Biokhimiia 2026 Vol. 91 P. 1842–1858
Involvement of the transcription factor Bach1 in various scenarios of cellular regulation is reviewed herein. To date, the most extensively studied role of Bach1 is that of a repressor of the antioxidant genetic program initiated by the Nrf2 factor. This program counteracts oxidative stress, which triggers both ferroptosis and the intrinsic apoptotic pathway. Bach1 functions unrelated ...
Added: October 22, 2026
Svirin E., Бердышев Д. А., Шишкин С. Л., Вестник Российского государственного медицинского университета 2026 № 3 С. 42–50
Quasi-movements (QMs), which are movement attempts minimized to the point of movement extinction, evoke EEG patterns similar to those of real movement. QMs can model attempted movement in healthy subjects and are therefore of interest as an alternative to motor imagery (MI) in rehabilitation brain–computer interfaces (BCIs), in which the attempted movement of the paralyzed ...
Added: October 22, 2026
Sitdikova K., Tsoy A., Chaprov K. et al., Journal of Neuropathology and Experimental Neurology 2026 Article nlag078
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alterations remains unclear. We used 6-month-old female APPswe/PS1dE9 mice, a model of early amyloid-dominant pathology, to assess cognition and emotionality across a battery of behavioral tests. Amyloid ...
Added: October 22, 2026
Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice
Kassenova A., Svirin E., Sitdikova K. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 11 Article 4994
Added: October 22, 2026
Cespuglio R., Schmitt-Böhrer A., Deykin A. et al., Metabolites 2026 Vol. 16 No. 2 Article 117
Added: October 22, 2026
Tomsk: Национальный исследовательский Томский политехнический университет, 2020.
В сборнике отражены проблемы палеонтологии, стратиграфии, тектоники, исторической и региональной геологии, минералогии, геохимии, петрологии, литологии, полезных ископаемых, металлогении, гидрогеологии, гидрогеохимии, инженерной геологии, геофизики, нефтяной геологии, геоинформационных систем в геологии, разработки нефтяных и газовых месторождений, переработки углеводородного и минерального сырья, нефтегазопромыслового оборудования, бурения нефтяных и газовых скважин, техники и технологии разведки и добычи, транспорта и хранения ...
Added: October 22, 2026
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Petrova D., Biomolecules 2025
Added: January 18, 2026
Nagornaya A., Логос 2025 № 5(168) С. 133–150
Cancer is one of the most profound challenges a person may face in their life. Not only does it torture the flesh, but it torments the soul, causing a deep and lasting existential crisis and calling for a major revision of the meanings that once seemed immutable. This meaning-making is an extremely complex and delicate ...
Added: October 6, 2025