Model of chromosomal loci dynamics in bacteria as fractional diffusion with intermittent transport

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2017. Vol. 96. No. 042402. P. 042402-1–042402-8.

Gherardi M., Calabrese L., Tamm M., Cosentino Lagomarsino M.

The short-time dynamics of bacterial chromosomal loci is a mixture of subdiffusive and active motion, in the form of rapid relocations with near-ballistic dynamics. While previous work has shown that such rapid motions are ubiquitous, we still have little grasp on their physical nature, and no positive model is available that describes them. Here, we propose a minimal theoretical model for loci movements as a fractional Brownian motion subject to a constant but intermittent driving force, and compare simulations and analytical calculations to data from high-resolution dynamic tracking in E. coli. This analysis yields the characteristic time scales for intermittency. Finally, we discuss the possible shortcomings of this model, and show that an increase in the effective local noise felt by the chromosome associates to the active relocations.

Keywords: anomalous diffusion, аномальная диффузия, фрактальное броуновское движение, Анализ данных в билогии, fractal Brownian motion, dynamics of bacterial chromosomes, data analysis in biology, динамика бактериальных хромосом