КРИТЕРИИ ОЦЕНКИ ЭХОКАРДИОГРАФИЧЕСКИХ ПОКАЗАТЕЛЕЙ У СПОРТСМЕНОВ
In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine
The influence of training load on the cardiovascular system of athletes of all ages and the duration of time. When comparing the athletes who train up to two years increased the size of the right ventricular performance, ejection fraction. Also observed lower values in fractional shortening. For the first 4-5 years of performance of the cardiovascular system of athletes of all ages characterize the economisation of the heart. Characteristics of echocardiographic parameters in athletes with little experience of employment indicates the influence of sports on the cardiovascular system. Noted changes can be described to a certain extent not only morphological changes, but also functional. It is established that the character of cardiac remodeling determined by the level of physical and functional training athletes of all ages and fitness facilities, the state of their health, as well as the intensity of training and competitive pressures.
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells. Oxyquinoline derivative inhibits HIF-prolyl hydroxylase by stabilizing HIF-1 transcription complex, thus modeling cell response to hypoxia. In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene. These changes in the expression profile attest to activation of the metabolic cell reprogramming mechanisms aimed at reducing oxygen consumption by enabling the switch from aerobic to anaerobic glucose metabolism and the respective decrease in number of mitochondria. The possibility of practical use of the therapeutic properties of oxyquinoline derivatives is discussed.