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Инвазивные интерфейсы мозг–компьютер: 25 лет клинических испытаний, научные и практические вопросы
Вестник Российской академии медицинских наук. 2024. Т. 79. № 5. С. 424–431.
Mokienko O.
A brain-computer interface (BCI) is a system that measures brain activity and converts it in real-time into functionally useful outputs to replace, restore, enhance, supplement, and/or improve the natural outputs of the brain. In invasive BCIs, electrodes are placed intracranially for more accurate and faster data exchange between the brain and external devices. The primary medical objective of these technologies is to compensate for motor or speech function in patients with tetraparesis and anarthria. In recent years, the emergence of new neuroimplants for BCIs and the results demonstrated in clinical trials have led to a notable increase in interest in these systems from the scientific community, investors, and the public. This review compares different types of medical invasive BCIs, analyzes and discusses the achievements and unsolved problems of clinical application of these neurotechnologies, as well as possible consequences and risks of their wider use.
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged
perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase
plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular
remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and
perivascular fibrosis, ...
Added: May 19, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
Сахарова Г. М., Антонов Н. С., Stadnik N., Здравоохранение стран СНГ 2025 Т. 1 № 1 С. 42–49
Introduction. Self-rated health is the most widely used indicator of health, taking into account all its components - physical and mental health, emotional, social and financial well-being. Although individuals rate their health based on their own perceptions, when aggregated, the indicator accurately represents the health of the entire population. The purpose of the study: based ...
Added: April 10, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Вопросы наркологии 2025 Т. 37 № 1 С. 27–43
In order to study the prevalence of signs of nicotine dependence among tobacco/nicotine users and the level of medical care for tobacco/nicotine use in addiction treatment organizations in the Russian Federation in 2013-2023, we have analyzed microdata from a sample observation of the health status of the population conducted in 2023. The analysis of the ...
Added: April 10, 2026
Антонов Н. С., Сахарова Г. М., Stadnik N., Электронный научный журнал "Социальные аспекты здоровья населения" 2025 Т. 71 № S3 Статья 13
Significance. A sedentary lifestyle is one of the four most important risk factors for developing non-communicable diseases. Regular physical activity can prevent from 4 million to 5 million deaths annually worldwide.
Purpose. To study the prevalence of a sufficient level of daily physical activity and its three components among the adult population, men and women, in ...
Added: April 9, 2026
Stadnik N., Антонов Н. С., Сахарова Г. М. et al., Профилактическая медицина 2025 Т. 28 № 6 С. 11–20
Studies on alcohol use generally analyze the age-related behavior associated with this factor but do not consider the attitude of people of different ages to the socio-economic situation, the absence or implementation of anti-alcohol policies, or the attitude change over time in people of different generations.
Objective. To analyze the features and changes over time of ...
Added: April 9, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Современные проблемы здравоохранения и медицинской статистики 2025 № 2 С. 50–69
In order to achieve global goals to reduce tobacco/nicotine use, the package of effective tobacco control measures must include the provision of medical assistance to stop tobacco and nicotine use.
Purpose. To analyze the organization of medical care for tobacco/nicotine quitting in the Russian Federation (RF) in accordance with established regulatory legal acts in the field ...
Added: April 9, 2026
Stadnik N., Никитина С. Ю., Сахарова Г. М. et al., Демографическое обозрение 2025 Т. 12 № 2 С. 132–156
The study assesses the dynamics of the prevalence and structure of alcohol consumption in Russia by age, gender and regions. The data source is the microdata databases of the Sample Survey of the Health Condition of the Population conducted by Rosstat in 2019-2023. The assessment of the dynamics of alcohol consumption is based on the ...
Added: April 9, 2026
Мурашко М. А., Салагай О. О., Антонов Н. С. et al., Общественное здоровье 2025 Т. 5 № 1 С. 4–18
Introduction. The article presents the results of a study assessing the association of alcohol consumption with the development of noncommunicable diseases (NCDs). The purpose of the study: to study the individual relative (OR) and population attributive risks (PAR) of developing NCDs in alcohol consumption among the adult population of the Russian Federation (RF), including depending on gender ...
Added: April 9, 2026
Stadnik N., Никитина С. Ю., Сахарова Г. М. et al., Демографическое обозрение 2024 Т. 11 № 1 С. 37–60
This study proposes a method to assess the dynamics of tobacco and nicotine consumption in Russia by age, gender and regions based on the data of the Sample Survey of the Health Condition of the Population conducted by Rosstat in 2019-2022. The data source is the microdata databases of the Survey. The assessment of the ...
Added: April 9, 2026
Mokienko O., Современные технологии в медицине 2024 Т. 16 № 1 С. 78–90
Brain–computer interfaces allow the exchange of data between the brain and an external device, bypassing the muscular system. Clinical studies of invasive brain–computer interface technologies have been conducted for over 20 years. During this time, there has been a continuous improvement of approaches to neuronal signal processing in order to improve the quality of control ...
Added: March 18, 2026
Исаев М. Р., Бобров П. Д., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 5 С. 728–738
The paper proposes methods for brain–computer interface, based on the hemodynamic activity registration using near–infrared spectroscopy (NIRS) and adapted for using in the movement disorders rehabilitation. Methods include a filtration adapted to the instructions frequency, step by step classification of the rest state and active tasks, as well as training of the interface classifier on ...
Added: March 18, 2026
Люкманов Р. Х., Исаев М. Р., Mokienko O. et al., Анналы клинической и экспериментальной неврологии 2023 Т. 17 № 4 С. 82–88
Introduction. Non-invasive brain–computer interfaces (BCIs) enable feedback motor imagery [MI] training in neurological patients to support their motor rehabilitation. Nowadays, the use of BCIs based on functional near-infrared spectroscopy (fNIRS) for motor rehabilitation is yet to be investigated. Objective: To evaluate the potential fNIRS BCI use in hand MI training for comprehensive post-stroke rehabilitation. Materials ...
Added: March 18, 2026