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  • Усиление цитотоксического действия цисплатина и актиномицина Д пиридиновым производным гидроксиламида янтарной кислоты
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Subject
News
September 30, 2026
'We Did Not Limit the Time for Questions'
The International Laboratory for Supercomputer Atomistic Modelling and Multi-Scale Analysis at HSE University held a major conference on molecular dynamics. Participants had the opportunity to attend all the presentations, while speakers were given as much time as they needed to answer questions. The HSE News Service interviewed Grigory Smirnov, Head of the Laboratory, and Genri Norman, Chief Research Fellow, about the conference preparations and the discussions it generated.
September 25, 2026
AI Users Earn Up to 41.8% More Than Non-Users
Research conducted by economists at HSE University has revealed a significant correlation between the regular use of GenAI in the workplace and higher pay among Russian employees. The study found that individuals who frequently use GenAI in their professional activities earn notably more than those who reject these new tools or resort to them occasionally. The salary premium for highly qualified specialists reaches 41.8%. The article was published in the Voprosy Ekonomiki journal.
September 24, 2026
‘Feedback and Constructive Criticism Are Essential in Our Profession
Vincent Fardeau, Associate Professor at HSE ICEF, has reached a major career milestone: he recently published his paper ‘Asymmetric Thin Markets’ in the Journal of Financial Economics, successfully passed his major academic review, and received tenure. In this interview, Vincent discusses the story behind the paper, explains the concept of asymmetric thin markets, and shares his advice for young scholars aiming to publish in top-tier journals.

 

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Усиление цитотоксического действия цисплатина и актиномицина Д пиридиновым производным гидроксиламида янтарной кислоты

Бюллетень экспериментальной биологии и медицины. 2023. Т. 175. № 1. С. 29–33.
Третьяков Б. А., Филатова Н. В., Мумятова В. А., Гадомский С. Я., Terentiev A.

The principal possibility of inhibition of histone deacetylases (HDACs) in nuclear extract of HeLa cells by N1-hydroxy-N4-(pyridine-4-yl)succinamide (compound 1) has been investigated. Compound 1 inhibits HDAC and exhibits low toxicity to A-172, HepG2, HeLa, MCF-7, and Vero cells. HeLa cells are most sensitive to the compound. With an increase in the interval between the administration of compound 1 and a chemotherapeutic agent to 8 hours, an increase in the cytotoxic effect of cisplatin or actinomycin D in HeLa cells was observed. On the other hand, the combination of compound 1 with cisplatin or actinomycin D reduced the cytotoxic effects of these drugs in Vero non-cancerous cells.

Research target: Chemistry Biology
Language: Russian
DOI
Text on another site
Keywords: цитотоксичностьCisplatinцисплатинhistone deacetylase inhibitorscytotoxicityhistone deacetylaseActinomycin Dгистондеацетилазыингибиторы гистондеацетилазактиномицин Д
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