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  • Наноразмерные системы фолиевая кислота-амфифильный сополимер N-винилпирролидона с метакриловой кислотой, разветвленный диметакрилатом триэтиленгликоля
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News
September 11, 2026
How to Assess Students Knowledge in the Age of AI
A researcher at HSE University has proposed a flowchart to help lecturers decide how to assess students who use artificial intelligence. It shows where the use of AI should be restricted and where it can be incorporated into the learning process. The article has been published in IT Professional.
September 9, 2026
‘Balkan Hospitality Opens Doors: Studying Dialects on the Verge of Extinction
You cannot study spoken dialects from books. Instead, you need to go to a village, seek out its elders, and earn the trust of local residents before you can record hours of spontaneous stories. This is how Natalia Muravleva, Associate Professor at the Faculty of Humanities, conducts her research. Her internship in Serbia continued her long-standing study of dialects spoken by Macedonian settlers. In this interview, she discusses how diaspora cultural centres help researchers reach informants, why native speakers need to be interviewed only in their own language (otherwise, as she puts it, they may 'break'), and how a single field season helped her finalise her monograph. She also shares warm memories of autumn in Belgrade and of colleagues with whom grammar can be discussed in three languages at once.
September 9, 2026
Scientists Train Neural Network to Generate Process Plans from 3D Models
Researchers at the HSE FCS AI and Digital Science Institute have developed CAD2TechSpec, a framework that converts 3D models of mechanical parts into machining process plans—step-by-step instructions for machine tools. The solution aims to reduce the time required for the design and preparation of technical process documentation in mechanical engineering, aircraft manufacturing, and other high-tech industries. The study findings have been published in PeerJ Computer Science.

 

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Наноразмерные системы фолиевая кислота-амфифильный сополимер N-винилпирролидона с метакриловой кислотой, разветвленный диметакрилатом триэтиленгликоля

Известия Академии наук. Серия химическая. 2023. Т. 72. № 6. С. 1349–1365.
Курмаз С. В., Иванова И., Фадеева Н. В., Игнатьев В. М., Емельянова Н. С., Лапшина М. А., Балакина А. А., Terentiev A.

Polymer compositions of folic acid based on an amphiphilic copolymer of N-vinylpyrrolidone with methacrylic acid branched with triethylene glycol dimethacrylate have been developed and characterized by the methods of DLS, 1H NMR, IRS, DSC and TGA in solutions and in solid state. The effective binding constants of folic acid to copolymer in isopropyl alcohol and in aqueous media were determined using electron absorption spectroscopy. The behavior of nanoscale systems in water as a function of the temperature and pH of the medium has been studied, and their hydrodynamic radii have been determined. Quantum chemical modeling of the structure of intermolecular complexes has been performed and it has been shown that hydrogen bonds formed by oxygen atoms of carboxyl groups of either folic acid or a unit of methacrylic acid with hydrogen atoms are weak. The cytotoxicity of polymer compositions with different folic acid content (0.5-4 wt.%) was studied in non-cancerous (FetMSC, Vero) and tumor cells HeLa (human cervical adenocarcinoma, clone M-HeLa) and HepG2 (human liver carcinoma) and it was found that they exhibited high biocompatibility. The dynamics of accumulation of polymer particles loaded with folic acid and fluorescent dye zinc tetraphenylporphyrinate in Vero and HeLa cells has been studied by fluorescence microscopy. The conclusion was made about the prospects of the developed compositions as targeted delivery systems.

Research target: Chemistry Biology
Language: Russian
DOI
Text on another site
Keywords: цитотоксичностьfluorescenceфлуоресценцияfolic acidcytotoxicityфолиевая кислотаN-vinylpyrrolidonetriethylene glycol dimethacrylatequantum chemical modelingN-винилпирролидондиметакрилат триэтиленгликоляквантовохимическое моделированиеmethacrylic acidamphiphilic copolymerscellular accumulationметакриловая кислотаамфифильные сополимерыклеточное накопление
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