Altered thalamotemporal structural connectivity is associated with autistic traits in children with ASD

Behavioural Brain Research. 2025. Vol. 481. Article 115414.

Миннигулова А. Ш., Карпычев В. В., Davydova E., Pereverzeva D., Sorokin A., Tyushkevich S., Mamokhina U., Danilina K., Драгой О. В., Arutiunian V.

Background

Thalamocortical functional and structural connectivity alterations may contribute to clinical phenotype of Autism Spectrum Disorder (ASD). As previous studies focused mainly on thalamofrontal connections in ASD, we comprehensively investigated the thalamic functional networks and white matter pathways projecting also to temporal, parietal, occipital lobes and their associations with core and co-occurring conditions of this population.

Methods

A total of 38 children (19 with ASD) underwent magnetic resonance imaging and behavioral assessment. Functional and structural scans were processed to analyze between-group thalamic connectivity differences and their relationships to measurements of autistic traits and language abilities.

Results

No functional differences were found between groups across 20 networks in each hemisphere. However, we showed that the diffusion properties of thalamocortical pathways projecting to the right and left temporal lobes were disrupted in children with ASD. Additionally, there was a significant association between diffusion differences of thalamotemporal tracts and severity of autistic traits.

Conclusions

Our findings on altered thalamotemporal structural but not functional connectivity contribute to the understanding of white matter organization of thalamocortical pathways in children with ASD.

Ключевые слова: трактография, таламус, фМРТ покоя, Расстройства аутистического спектра, Tractography, thalamus, Autistic traits, resting state fMRI, Autism Spectrum Disorder (ASD), аутистические черты

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