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October 1, 2026
HSE Researchers Show How Congenital Motor Disorders Affect Brain Development
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Add, subtract and multiply: Meta-analyses of brain correlates of arithmetic operations in children and adults

Developmental Cognitive Neuroscience. 2024. Vol. 69. Article 101419.
Istomina A., Arsalidou M.

Mathematical operations are cognitive actions we take to calculate relations among numbers. Arithmetic operations, addition, subtraction, multiplication, and division are elemental in education. Addition is the first one taught in school and is most popular in functional magnetic resonance imaging (fMRI) studies. Division, typically taught last is least studied with fMRI. fMRI meta-analyses show that arithmetic operations activate brain areas in parietal, cingulate and insular cortices for children and adults. Critically, no meta-analysis examines concordance across brain correlates of separate arithmetic operations in children and adults. We review and examine using quantitative meta-analyses data from fMRI articles that report brain coordinates separately for addition, subtraction, multiplication, and division in children and adults. Results show that arithmetic operations elicit common areas of concordance in fronto-parietal and cingulo-opercular networks in adults and children. Between operations differences are observed primarily for adults. Interestingly, higher within-group concordance, expressed in activation likelihood estimates, is found in brain areas associated with the cingulo-opercular network rather than the fronto-parietal network in children, areas also common between adults and children. Findings are discussed in relation to constructivist cognitive theory and practical directions for future research.

Research target: Psychology
Language: English
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Keywords: arithmeticcalculationactivation likelihood estimation (ALE) meta-analysisfronto-parietal networkcingulo-opercular networkArithmeticCalculationFronto-parietal networkCingulo-opercular network
Publication based on the results of:
Cognitive and affective processes in human cognitive activity (2024)
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