Altered neural synchronization in response to 2 Hz amplitude-modulated tones in the auditory cortex of children with Autism Spectrum Disorder: An MEG study

International Journal of Psychophysiology. 2024. Vol. 203. Article 112405.

Samoylov I., Arcara G., Buyanova I., Davydova E., Pereverzeva D., Sorokin A., Tyushkevich S., Mamokhina U., Danilina K., Dragoy O., Arutiunian V.

Objective: Some studies have hypothesized that atypical neural synchronization at the delta frequency band in the auditory cortex is associated with phonological and language skills in children with Autism Spectrum Disorder (ASD), but it is still poorly understood. This study investigated this neural activity and addressed the relationships between auditory response and behavioral measures of children with ASD. Methods: We used magnetoencephalography and individual brain models to investigate 2 Hz Auditory Steady-State Response (ASSR) in 20 primary-school-aged children with ASD and 20 age-matched typically developing (TD) controls. Results: First, we found a between-group difference in the localization of the auditory response, so as the topology of 2 Hz ASSR was more superior and posterior in TD children when comparing to children with ASD. Second, the power of 2 Hz ASSR was reduced in the ASD group. Finally, we observed a significant association between the amplitude of neural response and language skills in children with ASD. Conclusions: The study provided the evidence of reduced neural response in children with ASD and its relation to language skills. Significance: These findings may inform future interventions targeting auditory and language impairments in ASD population.

Keywords: Magnetoencephalography (MEG), магнитоэнцефалография (МЭГ), расстройства аутистического спектра, Autism Spectrum Disorder (ASD), Auditory Steady-State Response (ASSR)

Publication based on the results of: Neuroanatomical foundations of language disorders in children and adults: structural and functional correlates (2024)