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News
July 24, 2026
'Physics Is What the World Is Literally Built On'
Physicist Nina Dzhanayeva, recipient of a Vladimir Potanin Foundation scholarship, focuses her research on nanophotonics. In this interview for the HSE Young Scientists project, she discusses nanowells, scientific intuition, and how physics can help in making frangipane cream puffs.
July 20, 2026
Scientists Create Open Dataset for Studying Concentration
A team of Russian researchers, including scientists from HSE University–St Petersburg, has developed the first open multimodal dataset containing recordings of brain activity, heart function, and video observations to help researchers understand what happens in the human brain during deep concentration. In the future, the dataset could accelerate the development of neural interfaces, rehabilitation technologies, and AI systems. The article has been published in Scientific Data.
July 20, 2026
‘Science Is Universal-It Knows No Borders
Fuad Aleskerov, Tenured Professor and Director of the International Centre of Decision Choice and Analysis at HSE University, together with his colleagues, has developed methods of network analysis in bibliometrics that have made it possible to identify patterns in the appearance and citation of publications in academic journals, as well as their influence on each other. When one or a number of studies are frequently cited by a wide range of journals, this is an indicator that the research is of high quality. By contrast, extensive cross-citation within a limited group of journals increases the likelihood of identifying a network of predatory publications.

 

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Studies on Enzymatic Transglycosylation Catalyzed by bacterial Nucleoside Deoxyribosyltransferase II and Nucleoside Phosphorylase for the Synthesis of Pyrimidine 2′-Deoxyribonucleosides Containing Modified Heterocyclic Base

Sustainable Chemistry and Pharmacy. 2023. Vol. 32. Article 101011.
Konkina M. A., Drenichev M. S., Nasyrova D. I., Porozov Yu., Alexeev C. S.

A comparative analysis of enzymatic transglycosylation reactions catalyzed by Lactobacillus leich-mannii NDT II and Escherichia coli PNP in the presence of various glycosyl donors and under dif-ferent conditions was performed to synthesize modified 2MODIFIER LETTER PRIME-deoxynucleosides. Substitution of Es-cherichia coli PNP with Lactobacillus leichmannii NDT II allowed the synthesis of various deoxynu-cleosides from different glycosyl donors in 39-100% yields. The replacement of thymidine as a commonly used NDT substrate with 7-Methyl-2 '-deoxyguanosine as a novel glycosyl-donor al-lowed the enzymatic synthesis of 2 '-deoxycytidine derivatives and 5-substituted 2 '-deoxyuridine derivatives, which is essential for further elaboration of eco-friendly technologies for synthesis of base-modified nucleosides.

Research target: Basic Medicine Biology
Language: English
DOI
Keywords: Escherichia colinucleosidesenzymesDeoxyribosyltransferaseLactobacillus leichmanniiTransglycosylation
Publication based on the results of:
Molecular evolution, protein motions and computational molecular modeling (2023)
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