Modulation of cortical neural dynamics during thalamic deep brain stimulation in patients with essential tremor

Hohlefeld F.; Ehlen F.; Krugel L.; Kühn A.; Curio G.; Klostermann F.; V. Nikulin

?

Modulation of cortical neural dynamics during thalamic deep brain stimulation in patients with essential tremor

NeuroReport (UK). 2013. Vol. 13. No. 24. P. 751–756.

Hohlefeld F., Ehlen F., Krugel L., Kühn A., Curio G., Klostermann F., Nikulin V.

Although thalamic deep brain stimulation is an effective treatment for patients with essential tremor, little is known about its effect on cortical neural dynamics. Therefore, we investigated long-range temporal correlations and spectral power in electroencephalographic recordings of patients during OFF versus ON bilateral thalamic deep brain stimulation in comparison with healthy controls. Cortical dynamics were analyzed in the range of 6-30 Hz. We found the presence of long-range temporal correlations up to 20 s in patients and controls. Thalamic deep brain stimulation was associated with increased long-range temporal correlations in the high beta band (21-30 Hz) and decreased power in the low beta band (13-20 Hz) compared with OFF stimulation and healthy controls. Long-range temporal correlations in the 6-10 Hz range were increased with OFF stimulation compared with the controls. Importantly, deep brain stimulation-induced changes in long-range temporal correlations within 6-10 Hz and in the beta ranges (13-20, 21-30 Hz) were correlated with OFF-ON changes in the tremor severity and with the disease duration, respectively. The differential reactivity of long-range temporal correlations and spectral power to deep brain stimulation might suggest that both measures reflect distinct aspects of cortical dynamics and might represent biomarkers for stimulation-induced modulations of neural dynamics in electroencephalography. The fact that long-range temporal correlations, but not spectral power, were correlated with clinical information might suggest long-range temporal correlations as a potential marker for disease severity in essential tremor.

Research target: Mathematics Earth Sciences Biology

Priority areas: IT and mathematics

Language: English

Text on another site

Keywords: Neural oscillations detrended fluctuation analysis Temporal correlations Ventral Intermediate Nucleus

Modulational Instability and Wave Dynamics in the Rotated Modified Gardner–Whitham Equation

Flamarion M. V., Pelinovsky E., Chaos, Solitons and Fractals 2026 Vol. 213 No. 2 Article 119245

This article concerns the study of modulational instability in the rotated-modified Gardner–Whitham (rmGW) equation. This model incorporates both quadratic and cubic nonlinearities, similarly to the Gardner equation, while also retaining the fully dispersive character of the Whitham equation together with a large-scale dispersive term analogous to that in the Ostrovsky equation. Using a classical multiple-scale asymptotic expansion, we ...

Added: October 8, 2026

Space-Time Fluctuations in a Quasi-static Limit

Bernardin C., Gonçalves P., Olla S., Mathematical Physics Analysis and Geometry 2024 Vol. 27 No. 7

We consider the macroscopic limit for the space-time density fluctuations in the open symmetric simple exclusion in the quasi-static scaling limit. We prove that the distribution of these fluctuations converge to a gaussian space-time field that is delta correlated in time but with long-range correlations in space. ...

Added: October 6, 2026

To spike or not to spike: the whims of the Wonham filter in the strong noise regime

Bernardin C., Chhaibi R., Najnudel J. et al., Probability Theory and Related Fields 2026 Vol. 195 P. 1823–1875

We study the celebrated Shiryaev-Wonham filter (Wonham, W.M., in J. Soc. Ind. Appl. Math. 347–369, 1964) in its historical setup, where the hidden Markov jump process has two states. We are interested in the weak noise regime for the observation equation. Interestingly, this becomes a strong noise regime for the filtering equations. Earlier results of ...

Added: October 5, 2026

Цепная дробь Аски–Вильсона при qN=1

Ismailov A., Spiridonov V., Успехи математических наук 2026 Т. 81 № 5 С. 183–184

Получена новая формула для цепной дроби Аски–Вильсона в форме отношения двух q-гипер-геометрических рядов. ...

Added: October 5, 2026

Explicit Formula for Inverse and Determinant in Geometric Algebras over Odd-dimensional Vector Spaces

Abdulkhaev K., Shirokov D., Advances in Applied Clifford Algebras 2026 Vol. 36 P. 1–21

In this paper, we present explicit formulas for the inverse and determinant in geometric (Cliﬀord) algebras over vector spaces of dimension n = 7. The derivation of these formulas is made possible by generalizing the concept of conjugation to basis conjugation operations. We further develop a general method for constructing such formulas over odd-dimensional spaces ...

Added: October 4, 2026

On Practical Aspects of Constructing Quasi-Cyclic Subfield Subcodes of Dual Elliptic Codes and Their Application in McEliece-type Cryptosystems

Kuninets A., IEEE Transactions on Information Theory 2026 P. 1–1

In this work we study the applicability of Quasi-Cyclic Subfield Subcodes of Dual Elliptic (QC-SSDE) codes for integration into code-based cryptographic schemes. Detailed algorithms are provided for constructing parity-check matrices as well as block-circulant parity-check matrices for this family of codes, accompanied by empirical results that enable the construction of QC-SSDE codes with predetermined dimensions. ...

Added: October 3, 2026

HLA class I escape drives the evolution of SARS-CoV-2 in human populations

Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20

The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...

Added: October 2, 2026

Graphon spin systems as exactly solvable models

Medvedev G., Alexandrov Artem, Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 Article 044102

Graphons are measurable functions used to describe the asymptotic behavior of convergent graph families. Originally motivated by problems in combinatorics and graph theory, graphons have found numerous applications in the modeling and analysis of dynamical processes on networks. In this work, we use graphons to formulate the Ising model on convergent graph sequences, which include ...

Added: October 2, 2026

Планетарное зацепление трилистника

Pochinka O., Baranov D., Nozdrinova E., Теоретическая и математическая физика 2026 Т. 229 № 1 С. 3–14

The Birman–Williams problem on describing the planetary link of a fibered knot K in S^3 has been partially solved. Using Nielsen's theory for the classification of periodic surface homeomorphisms and its close relationship with the theory of gradient-like diffeomorphisms, it is proved that the planetary link of the trefoil (the unique periodic fibered knot of genus ...

Added: October 2, 2026

Pericyte-derived cancer-associated fibroblasts correlate with poor survival and are enriched after chemoradiotherapy in glioblastoma

Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902

Added: October 2, 2026

A quantum–analogue formalism for modeling supraliminal information processing

Lubashevsky I., Lubashevskiy V., Physica D: Nonlinear Phenomena 2026 Vol. 498 Article 135441

We develop a novel cloud-function formalism describing the dynamical relationship between sensory-information processing in large-scale brain networks (supraliminal processing) and the content of the mental representation of an observed object. The formalism combines elements of neural field theory for large-scale neural activity with the spatial characteristics of perceived objects and their embedding in the environment ...

Added: October 2, 2026

Консервативные энтропийно и энергетически корректные разностные методы для одномерных квазигазодинамических систем уравнений

Zlotnik A., Математические заметки 2026 Т. 120 № 6 С. 1005–1009

Численным методам решения систем газодинамических уравнений посвящена обширная литература. Ранее было разработано и успешно апробировано специальное семейство симметричных по пространству консервативных разностных методов, основанных на предварительной кинетической, точнее, квазигазодинамической (КГД), регуляризации этих уравнений. Актуальной задачей является построение численных методов, которые обладают не только свойством консервативности по массе, импульсу и полной энергии, но и удовлетворяют условиям энтропийной ...

Added: October 1, 2026

On some arithmetic conditions of recurrent sequences modulo prime p

Vyugin I. V., Sashadhar D., Algebra and Number Theory 2026 P. 1–10

We study the K-Fibonacci sequence Fp modulo prime p. Cardinalities of sets |Fp+Fp| and |Fp⋅Fp| are estimated. We present the method of estimating doubling constant of some m-dimensional recurrent sets in Fp. ...

Added: October 1, 2026

Long-time behaviour of dynamical systems driven by bounded mixing noises

Kuksin S., Dynamical Systems 2026

We study the mixing properties of discrete-time and continuous-time dissipative dynamical systems driven by bounded mixing random forces. The continuous-time systems are reduced to discrete-time random dynamical systems generated by time-one maps, so that the main analysis is carried out in the discrete setting. We introduce a class of mixing random forcings whose regular conditional distributions with ...

Added: October 1, 2026

A Three-Party W-State Quantum Secret Sharing Protocol with X-Gate Encoding and Forbidden-Outcome Detection

Teregulov T., Loubenets E. R., / Series Quantum Physics "arXiv". 2026. No. 2609.31472.

We develop a new three-party quantum secret-sharing (QSS) protocol based on a three-qubit W state. This protocol encodes the secret-sequence bits using X gates and employs randomly selected Hadamard operations and measurement bases to generate information and security-test rounds. We evaluate the efficiency of the proposed protocol and analyze its security against an internal adversary ...

Added: September 28, 2026

A modified Multifractal Detrended Fluctuation Analysis (MFDFA) approach for multifractal analysis of precipitation

Morales Martínez J. L., Segovia-Domínguez I., Quiros Rodríguez I. et al., Physica A: Statistical Mechanics and its Applications 2021 Vol. 565 Article 125611

Added: September 18, 2026

Multifractal Analysis of Monthly Precipitation in a Semi-Arid Region of Central Mexico: Guanajuato, 1981–2016

Morales Martínez J. L., Ortega Chávez V. M., Sosa Gómez G. et al., Water (Switzerland) 2026 Vol. 18 No. 8 Article 911

Added: September 18, 2026

On calibration of remote sensing retrievals of ecosystem respiration (Reco) with tower measurements over,Russian forests and wetlands

Shabanov N., Kuricheva O., Kurbatova J. et al., / Series Working Papers SSRN "Department of Economics Ca’ Foscari University of Venice". 2026.

The carbon balance of an ecosystem is the difference between Gross Primary Productivity (GPP) and Ecosystem Respiration (Reco) as expressed by Net Ecosystem Exchange (NEE). While remote sensing retrievals of GPP have reached maturity, Reco estimation remains underexplored and ultimately cast bias on NEE. Here we present an end-to-end multi-scale analysis of the mechanism of ...

Added: August 21, 2026

Three Algorithms for Merging Hierarchical Navigable Small World Graphs

Ponomarenko A., / Series Computer Science "arxiv.org". 2025.

This paper addresses the challenge of merging hierarchical navigable small world (HNSW) graphs, a critical operation for distributed systems, incremental indexing, and database compaction. We propose three algorithms for this task: Naive Graph Merge (NGM), Intra Graph Traversal Merge (IGTM), and Cross Graph Traversal Merge (CGTM). These algorithms differ in their approach to vertex selection ...

Added: July 30, 2026

Growth in noncommutative algebras and entropy in derived categories

Piontkovski D., / Series arXiv "math". 2026.

A noncommutative projective variety is defined, following Artin and Zhang, by a graded coherent algebra 𝐴. The category of coherent sheaves is then the quotient qgr(𝐴) of the category of finitely presented graded modules by the subcategory of torsion modules. We consider the categorical and polynomial entropies of the Serre twist, that is, of the ...

Added: June 23, 2026

Multilinear nilalgebras and the Jacobian theorem

Piontkovski D., / Series arXiv "math". 2025.

If a symmetric multilinear algebra is weakly nil, then it is Engel. This result may be regarded as an infinite-dimensional analogue of the well-known Jacobian theorem, which states that if a polynomial mapping has a polynomial inverse, then its Jacobian matrix is invertible. This refines a theorem of Gerstenhaber and partially answers a question posed ...

Added: June 23, 2026

ML-based Fast Simulation of FARICH Responses

Shipilov F., Barnyakov A., Ivanov A. et al., / Series Physics "arxiv.org". 2026.

A fast simulation of the detector response is a vital task in high-energy physics (HEP). Traditional Monte-Carlo methods form the backbone of modern particle physics simulation software but are computationally expensive. We present a machine-learning-based approach to fast simulation of the Focusing Aerogel Ring Imaging Cherenkov (FARICH) detector response. Given a particle track and momentum, ...

Added: May 19, 2026

Natural hazard database from Internet publications: text mining with a large language model

Derkacheva A., Sakirkina M., Kraev G. et al., /. 2026.

Comprehensive data on natural hazards and their consequences are crucial for effective for risk assessment, adaptation planning, and emergency response. However, many countries face challenges with fragmented, inconsistent, and inaccessible data, particularly regarding local-scale events. To address this data gap in Russia, we developed an end-to-end processing pipeline that scrapes news from various online sources, ...

Added: April 28, 2026

Algorithmic overlaps as thermodynamic variables: from local to cluster Monte Carlo dynamics in critical phenomena

Pilé I., Deng Y., Shchur L., / Series arXiv "math". 2026. No. 2604.10254.

We investigate the spatial overlap of successive spin configurations in Markov chain Monte Carlo simulations using the local Metropolis algorithm and the Svendsen-Wang and Wolff cluster algorithms. We examine the dynamics of these algorithms for two models in different universality classes: the Ising model and the Potts model with three components. The overlap of two ...

Added: April 20, 2026