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Влияние состава на вязкость растворов и структуру высокопористых композиционных материалов альгинат–поливинилпирролидон– карбонатгидроксиапатит
Composite gels based on polyvinylpyrrolidone (PVP) and alginate (Alg) with carbonate hydroxyapatite (CHA) were obtained. Their kinematic and dynamic viscosities were measured. It has been shown that the introduction of CHA in an amount of up to 40 % by weight of polymers leads to a decrease in kinematic viscosity, and the introduction of 50 % by weight. CHA significantly increases it. The dependence of the dynamic viscosity of PVP gels with Alg 1:1 and composite gels is in the nature of pseudoplastic liquids and to a lesser extent depends on the content of CHA. Highly porous composite materials were obtained from composite gels by lyophilization. Their microstructure and porosity were studied and the average pore size was determined. It is shown that the volume fraction of pores decreases from 95 to 70 % by volume and the average pore size decreases from 325 to 166 µms when adding CHA to 40 % by weight. The mechanical properties of composites during compression testing are investigated. They have been shown to exhibit behavior characteristic of macroporous structures. The modulus of elasticity increases from 8 to 184 kPa with an increase in the CHA content from 10 to 50 wt. % It was found that composites exhibit reversible deformation at the level of 98 %. The results obtained provide an understanding of the effect of the composition on the viscosity and porosity of composite materials based on alginate with CHA obtained by lyophilization of the solution. The results of mechanical compression and reversible deformation tests allow us to consider the obtained composites for use in bone grafting.