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Разработка и сравнительный анализ составов трансдермальных пластырей с гуминовыми производными
Вопросы биологической, медицинской и фармацевтической химии. 2023. Т. 26. № 10. С. 3–11.
Коннова М. А., Волков А. А.
Fulvic acid as a fraction of humic substances is a hydrophilic molecule that can form aggregated particles in solutions. This can cause problems in the development of topical formulations such as ointments, gels and transdermal patches. In such cases, the development of formula-tions improving the penetration of small polar molecules through the lipophilic stratum corneum are required. Aim of the report – the development of compositions of transdermal therapeutic system and study of release of humic derivatives from them. Material and methods. Objects of the study: Transdermal patch is a dosage form for external use intended for controlled delivery of a medicinal substance (substances) into the systemic circulation by passive diffusion through intact skin. Fulvic acid (FA) was studied as humic derivatives. De-termination of the release rate of the active substance from the base and modified formulations was carried out according the pharmaceutical article Dissolution for transdermal patches. Determination of the concentration of fulvic acid in the aqueous extracts is carried out using spectrofluorimetry (spectrofluorimeter SolarCM 2203). Results. Emulsion transdermal patches have been developed and investigated. Based on the dissolution test for transdermal patches, the following results were obtained. The amount of FA released from the transdermal patches, with an initial content of 0.016 g, was equal to: (0.0081±0.0002) g (composition 1, Kolliphop p237) in 8.25 hours (495 minutes); (0.0046±0.0003) g (composition 2, Kolliphor p338), for 8.5 hours (510 min); (0.0048±0.0002) g (basic composition), for 6.5 hours (390 min). Conclusions. From the results of the experiment, it can be concluded that the modified composition 1 (Kolliphor p237) showed the best result in the release of fulvic acid in comparison with other compositions.
Korotkova E., Kulikova S., Lvova O. et al., Pediatric Radiology 2026 P. 1–9
Background
Predicted brain age is a widely used neuroimaging biomarker of brain maturation. However, limited normative pediatric datasets in model training raise concerns about systematic biases when applied to children. This study evaluates the hypothesis of predicted brain age overestimation in typically developing pediatric populations.
Objective
To analyze predicted brain age and brain delta in a large, age- ...
Added: October 3, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Kang J., Kim H. J., Kim M. S. et al., Nature Medicine 2026 No. 32 P. 527–544
Added: September 9, 2026
Khodadoust J., Kulikova S., Khodadoust F., Biomedical Signal Processing and Control 2027 Vol. 129 Article 111284
Acute ischemic stroke (AIS) analysis from two-dimensional (2D) clinical imaging is hindered by uncontrolled slice tilt and geometric inconsistencies that violate the assumptions of pose-agnostic deep learning (DL) models. This paper proposes a unified geometry-aware, frequency-domain framework for tilted slice localization and ischemic stroke segmentation that explicitly decouples pose estimation from lesion analysis. The method ...
Added: September 2, 2026
Bubnova M., Chetverikov V., Pozhidaev E., Информационные технологии 2026 Т. 32 № 8 С. 404–413
A specialized methodology was developed, computer modeling was conducted, and a comparative analysis was performed for autonomous control methods for small spacecraft, differing in how the nonlinearity of the initial stabilization problem is taken into account:
— control constructed using a system of linear differential equations (SLDE);
— control constructed using SLDE applied to a more general ...
Added: September 2, 2026
Волчкова Е. А., Легкова К. С., Минушкина Л. О. et al., Российский кардиологический журнал 2026 Т. 31 № 8S Статья 6987
Goal. To assess the contribution of polygenic risk scores to the short‑term mortality prediction model in patients with dilated cardiomyopathy (DCM).
Materials and methods. The study included 137 patients with DCM. The mean age was 56.8 ± 13.5 years; there were 115 men (83.9 %). The median follow‑up period was 17 [13; 22] months. During the follow‑up period, 26 ...
Added: August 24, 2026
Tsydypova M., Современные проблемы дистанционного зондирования Земли из космоса 2026 Т. 23 № 3 С. 263–275
The article presents a methodology for mapping coniferous forest decline, based on the integration of automated remote sensing data interpretation techniques, vegetation indices, remote sensing data on above-ground biomass (Biomass CCI (Climate Change Initiative)), and materials from ground-based forest pathology surveys using forests of the Khamar-Daban ridge (Republic of Buryatia) as a case study. The ...
Added: August 9, 2026
Elena A. Andresyuk, Natalya O. Porozova, Londaridze G. et al., Frontiers in Oncology 2026 Vol. 16 Article 1875861
Inhibition of the PD-1/PD-L1 axis has become a clinical standard across multiple malignancies, yet durable benefit remains restricted to selected settings, and many biologically rational combinations fail to maintain clinical benefit in late-phase evaluation. This structured, registry-derived narrative review, supported by expert-guided interpretation, was designed to identify the most clinically meaningful development directions among strategies ...
Added: July 31, 2026
Manivelan S. V., Srinivasan S., Thamilmaran K. et al., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 No. 1 Article 014217
This study investigates the dynamical origins and statistical properties of extreme events (EEs) in a diffusively coupled theoretical Brusselator system, extending from pairwise interactions to globally coupled networks. Statistically, the emergence of EEs is characterized by heavy-tailed probability density functions and exponential interevent interval distributions, alongside an analysis of the complementary cumulative distribution function and ...
Added: July 15, 2026
Wang R., He Y., Myachykov A. et al., Neuroimage 2026 Vol. 332 Article 121926
Insomnia disorder (ID) exhibits considerable heterogeneity in neuroimaging findings across studies, and whether functional brain alterations are consistent across resting and task states remains unclear. This study aimed to identify neural dysfunction across states in ID and explore its transcriptomic correlates. ...
Added: July 13, 2026
Shestoperov A. I., Ivchenko A., Fomina E. V., Microgravity Science and Technology 2025 Vol. 37 Article 19
The paper is dedicated to the analysis of medico-biological data obtained during locomotor testing of astronauts. Accurate data interpretation plays a crucial role in locomotion system monitoring, prophylaxis of long-duration spaceflight negative effects and thus in the development of an autonomous medical support system for deep space expeditions. During the locomotor testing the astronaut changes ...
Added: June 26, 2026
Мелешко Е. В., Афанасенко Т. С., Ш. М. Гаджимирзаев et al., Компьютерные исследования и моделирование 2022 Т. 14 № 6 С. 1255–1268
This work contains a description of the results of modeling the process of maintaining the readiness of a section of the road network under strikes of with specified parameters. A one-dimensional section of road up to 40 km long with a total number of strikes up to 100 during the work of the brigade is ...
Added: June 26, 2026
Vasilev R., Savchenko A., Blinov P. et al., Frontiers in Medicine 2026 Vol. 13 Article 1778404
Automated disease screening systems face challenges when applied to multi-class medical image analysis, particularly under severe class imbalance inherent in clinical datasets. Retinal fundus imaging enables non-invasive screening for multiple ocular and systemic diseases simultaneously, yet current automated systems typically assess risk for only a single pathology or a limited disease range. We developed a ...
Added: June 16, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
ЯКУБЕНКО Т. В., Plotnikov S., Ratio et Natura 2024 № 3 (11) Статья 10
The article presents the results of our own research aimed at studying the prospects of using genetic sequencing technologies to identify the risk of having children with genetic abnormalities. ...
Added: May 21, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Thangavel B., Kathamuthu T., Srinivasan S., International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 2026 Vol. 36 No. 09 Article 2630019
In this paper, we report, for the first time, that Extreme Events (EEs) can robustly emerge in autonomous, weakly coupled Bonhoeffer–van der Pol oscillators, challenging the prevailing notion that strong interaction and external drive are necessary for such rare, large-amplitude bursts. Our central finding is a novel dynamical route to EEs: a transition from quasi-periodic torus dynamics to ...
Added: May 20, 2026
Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42
Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere.
Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...
Added: May 18, 2026
Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110
Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...
Added: April 29, 2026
Kychkin A., Chernitsin I., Прикладная информатика 2026 № 1(121) С. 40–58
The results of the development of a software microservice embedded in atmospheric air quality monitoring systems to support the identification of industrial pollution sources are presented. The emission and subsequent spread of harmful substances in the lower layers of the atmosphere is dynamic and characterized by high uncertainty due to the specific features of technological ...
Added: April 23, 2026
Krasnov L., Malikov D., Kiseleva M. et al., Journal of Medicinal Chemistry 2026 Vol. 69 No. 8 P. 8838–8851
In this work, we developed a straightforward data-driven approach to predict the cytotoxicity of metal complexes based entirely on their (metal + ligands) composition. To this end, we have manually curated MetalCytoToxDB─a comprehensive experimental database comprising 26,500 IC50 values for 7050 metal complexes against 754 cell lines from 1921 articles. Based on these, machine learning ...
Added: April 23, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Коннова М. А., Волков А. А., Мельникова Н. Б., Медико-фармацевтический журнал «Пульс» 2024 Т. 26 № 7 С. 138–143
Fulvic acids (FA) are natural organic compounds obtained from the peat in the Nizhny Novgorod region
and used in the pharmacy, and require comprehensive studies not only to determine the authenticity, assay of the
main substance and impurities, but also to standardize the product. This is due, first of all, to the fact that
depending on the FA ...
Added: September 8, 2025