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Thermogenesis and reduced lipid synthesis: one-anastomosis gastric bypass bariatric surgery 6-mo follow-ups in adipose tissue health context for type 2 diabetes
American Journal of Physiology - Endocrinology and Metabolism. 2025. Vol. 329. No. 1. P. 86–101.
Stafeev I., Agareva M., Michurina S., Tomilova A., Shestakova E., Voznesenskaya A., Sineokaya M., Boldyreva M.
Background: One-anastomosis gastric bypass (OAGB) represents a novel less invasive bariatric surgery technique which can significantly improve systemic metabolism and adipose tissue health in type 2 diabetes mellitus (T2DM) patients. Previously, we demonstrated that T2DM impairs proliferation and differentiation of adipose tissue progenitors. Methods: Obese patients with T2DM (N=10) underwent clinical examination and subcutaneous fat biopsy during bariatric surgery and in 6-months. Adipose-derived stem cells (ADSC) were isolated by enzymatic method. Cell proliferation was analyzed using MTT assay and immunocytochemistry. Adipogenesis and thermogenesis were assessed by confocal microscopy. Adipocytes metabolism was estimated by radioisotope tracing. Western blotting was employed to quantify protein expression. Results: Median weight loss after OAGB was 40 kg. OAGB resolved hyperinsulinemia and stimulated insulin sensitivity with changes in HOMA-IR and M-index up to 2-fold. Bariatric surgery significantly influenced properties of ADSC adipocytes: there were an increase in ADSC proliferation, decrease in white adipogenesis, activation of white and beige adipocytes lipid droplet fragmentation, activation of thermogenesis and inhibition of lipogenesis. Conclusions: OAGB promotes weight loss and insulin sensitivity and changes regenerative potential of ADSC. Enhanced ability of ADSC to proliferate and differentiate into thermogenic adipocytes with reduced activity of lipogenesis may prevent weight gain after bariatric surgery.
Language:
English
Dmitrova E., Буклина С. Б., Gronskaya N. E. et al., Вопросы нейрохирургии им. Н.Н. Бурденко 2026 № 90(4) С. 87–94
Effective intraoperative speech mapping requires specific test with standardized linguistic material. The last one should capture speech function supported by brain region targeted for resection. It is necessary to develop a test tailored to specific patient’s needs and document intraoperative linguistic support. The objective of this report was to describe the procedure of intraoperative speech testing and battery of intraoperative tests for Russian language. We correlated intraoperative tests with brain regions and speech functions, as well as presented an application ...
Added: August 12, 2026
Provlotskaya I., Minnigulova A., Gordeyeva E. et al., Brain Structure and Function 2026 Vol. 231 Article 113
The Wada test is an invasive procedure used to assess language and memory lateralization. Despite the widespread use of the Wada test in the population of people with epilepsy, the two existing standardized protocols for conducting the procedure are methodologically different and do not fully account for language comprehension as a separate domain. In this ...
Added: August 4, 2026
Хайлова Ж. В., Омельяновский В. В., Терян Р. А. et al., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
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Sun Z., Khvostikov A., Krylov A. et al., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Turkina A., Vinogradova O., Lomaia E. et al., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Liapin G., Vlassov V., DIALOGUES IN HEALTH 2026 Vol. 8 Article 100317
Objectives
Due to the economic growth at the end of the 20th century, people in low-income countries live longer but still spend most of their income on food. These countries, as well as affluent countries, demonstrate a rising prevalence of obesity. The interplay of longevity and obesity at different levels of economic development is not clear.
Methods
We ...
Added: June 29, 2026
Minnigulova A., Dragoy O., Arutiunian V., European Child and Adolescent Psychiatry 2026
Communication deficits in Autism Spectrum Disorder (ASD) involve impairments in both verbal and nonverbal domains, potentially associated with altered brain network connectivity related to language, attention, and social cognition systems. This study investigated functional connectivity patterns among the Default Mode Network (DMN), Salience Network (SN), Dorsal Attention Network (DAN), and Language Network (LN) in male children ...
Added: June 18, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Lifshits A., Святохина Е. В., Одиссей: Человек в истории 2026 № 1 С. 156–173
This article introduces a new source for scholarly discussion on the history of Russian language, science, and culture in the late 17th century. Numerous Russian captions for engravings were discovered in a copy of the "Travnik" (Herbal) by the great Renaissance botanist and pharmacist Pietro Andrea Mattioli, published in Prague in German in 1563. In ...
Added: June 15, 2026
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Kolosnitsyna M., Deeva A., Вопросы экономики 2026 № 7 С. 92–108
This article presents the assessment of gross domestic product (GDP) losses in Russia resulting from mortality attributable to overweight-related diseases. The study is performed on multiple data sources, including overweight-related mortality rates, demographic indicators and labour market characteristics, i.e., employment structure, total mortality and population size subject to age and gender, and also Russia’s GDP ...
Added: June 3, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Медицина 2026 Т. 14 № 2 С. 42–57
A global step in the fight against tobacco was the adoption of the WHO Framework Convention on Tobacco Control in 2003, which includes the organization of monitoring of the prevalence of tobacco consumption. The main condition for monitoring is its organization based on representative surveys of the population and its individual groups, as well as ...
Added: June 3, 2026
Mokienko O., Zisman M. A., Bobrov P. et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Gerges M., Evgenyeva E., Isakova D. et al., American Journal of Health Behavior 2026 Vol. 50 No. 2 Article 2516
Objectives: Maladaptive eating behaviors characterize overeating disorders and are often accompanied by emotion dysregulation. Physiological mechanisms remain poorly understood. This study investigated psychophysiological responses to food-related, aversive, and neutral stimuli under different emotion regulation strategies.
Methods: Sixty-four adults (75% female; mean age = 45.6 years) with BMI ≥ 25 kg/m² participated (50 with overeating disorder, 14 ...
Added: April 28, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Deeva A., Applied Econometrics 2025 No. 4(80) P. 47–67
This paper investigates the influence of Body-Mass-Index (BMI) on the earnings of men and women. The aim is to identify weight — wage discrimination in the Russian labour market, which results in overweight and obese people earning significantly less than normal weight workers. The study is conducted using a panel dataset from the Russian Longitudinal ...
Added: October 2, 2025
Ng M., Gakidou E., Lo J. et al., The Lancet 2025 Vol. 405 No. 10481 P. 813–838
Background
Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050.
Methods
Leveraging established ...
Added: March 9, 2025