Influence of the lipid composition of lipid droplets on the efficiency of their protein-free fusion

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Influence of the lipid composition of lipid droplets on the efficiency of their protein-free fusion

Biophysical Reviews. 2023. Vol. 15. Article 1505.

Senchikhin I., Urodkova E. K., Minkevich M. M., Denieva Z. G., Molotkovsky R. J.

The work is dedicated to the study of the fusion of lipid droplets — organelles consisting of a core of fatty acids, such as triolein, surrounded by a monolayer of phospholipids. In view of the relatively simple implementation and universality of the effect of the lipid composition of the LC membranes on the efficiency of their fusion, a targeted change in the lipid composition seems to be a convenient tool for promising therapy of diseases associated with metabolic disorders.

As part of the work, we studied the protein-free fusion of lipid droplets, leading to the unification of their monolayer shells. This process requires overcoming the energy barrier E associated with the topological rearrangement of merging lipid monolayers. We have evaluated the energy barrier and studied the effect of lipid composition on the height of this barrier.

Research target: Chemistry Physics Nanotechnologies

The effect of ultra-rapid electron detachment from negative ions on effective attachment coefficient in H2O:O2 and H2O:air mixtures at moderate reduced electric fields

Ponomarev A., Aleksandrov N., Journal of Physics D: Applied Physics 2026 Vol. 59 Article 315205

Electron attachment and detachment in H2O:O2 and H2O:air mixtures are theoretically studied at moderate (40–100 Td) reduced electric fields. It is shown that there are two synergistic mechanisms of ultra-rapid electron detachment from negative ions in these mixtures, whereas these detachment channels are absent in pure gases. Effective attachment coefficient calculated with consideration for fast ion–molecule ...

Added: August 6, 2026

Conductance measurements cannot distinguish crossed Andreev reflection from elastic co-tunnelling in normal–superconductor–normal junctions

Khrapai V., Tikhonov E., Nature Physics 2026 P. 1–2

Feng et al.1 presented transport measurements of three-terminal normal–superconductor–normal devices based on topological insulator nanowires. They measured the full differential conductance matrix, defined as Gij = ∂Ii /∂Vj , beyond the linear response regime as a function of various control parameters. Here i, j∈ [1, 2] denote normal terminals biased by the voltages V1 and ...

Added: August 5, 2026

Modeling of the Influence of Temperature on Interaction of a Cathode with a Thin Insulating Film and a Glow Gas Discharge Plasma in a Mixture of Argon and Mercury Vapor

G. G. Bondarenko, Kristya V. I., Savichkin D. O. et al., Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques 2026 Vol. 20 No. 2 P. 417–423

A model of a glow gas discharge in a mixture of argon and mercury vapor is formulated in the presence of a thin insulating film on the cathode surface. Dependences of the discharge characteristics on the mixture temperature are calculated in the range of its variation, in which a noticeable contribution to ionization of the working gas is ...

Added: August 1, 2026

Источник одиночных фотонов с использованием коллоидных квантовых точек CdSe/CdS/ZnS на волноводах из нитрида кремния

Касимов Р. Х., Аржанов А. И., Седых К. О. et al., Оптический журнал 2026 Т. 93 № 1 С. 80–86

Предмет исследования. Использование метода капельного нанесения для изготовления источника одиночных фотонов. Цель работы. Разработка технологического процесса изготовления источника одиночных фотонов на коллоидных квантовых точках для использования их в фотон- ных интегральных схемах. Метод. На первом этапе в программе ANSYS Lumerical рассчитыва- ются период и фактор заполнения фокусирующих элементов связи на длинах волн 545 и 600 ...

Added: July 31, 2026

Non-Volatile Stochastic Photonic Element with Memory Based on Chalcogenide Material

Nevzorov A., Golikov A., Gneushev D. et al., JETP Letters 2026 Vol. 147–151 No. 3 P. 147–151

This paper demonstrates a special stochastic operation mode of a photonic element with a thin GeTe film deposited at a silicon nitride waveguide. As opposed to traditional deterministic switching between stable states, it has been shown that identical pump laser pulses cause a stochastic change in the transmission coefficient. The discovered effect opens up new ...

Added: July 31, 2026

Dual-mode infrared detection via photovoltaic and barrier pyroelectric effects in PbTe p–n junctions

Jarashneli A., Кобцев Д. М., Upcher A. et al., Journal of Applied Physics 2026 Vol. 140 No. 2 Article 024501

In the work, two effects appeared in PbTe p–n junctions under mid-wavelength infrared (2 − 5 μm) and long-wavelength infrared irradiation (≈10.6 μm). The first effect was created by the optical absorption of lR-photons in PbTe and caused by its photovoltage effect. The second novel effect is related to the heating process and the formation ...

Added: July 31, 2026

Electrical detection of spin resonance with time resolution in a two-dimensional electron system

Nikolaev G. A., Orlov O. V., Andreeva S. et al., Physical Review Applied 2026 Vol. 26 Article 014099

We report the electrical detection of the spin resonance with temporal resolution in a two-dimensional electron system. Spin resonance was excited by pulses of subterahertz radiation characterized by relatively short rise and fall times on the order of 10 ns and was observed as a resonant peak in the high-frequency conductivity of the two-dimensional channel. The ...

Added: July 31, 2026

Criticality of a pseudospin phase transition

S. A. Andreeva, Orlov O. V., A. V. Shchepetilnikov et al., Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 114 No. 6 Article 065420

We investigate the temperature dependence of the pseudospin phase transition at filling factor 𝜈=2 in the quantum Hall regime. Experiments were performed on a high-quality, wide AlAs quantum well, where the pseudospin degree of freedom arises naturally from the near degeneracy and equivalence of the two conduction-band valleys. The anisotropic 𝑔-factor inherent to AlAs enabled independent measurement of ...

Added: July 31, 2026

Surface-sulfonated Al₂O₃, CeO₂, and TiO₂ as functional fillers for Nafion-type gel polymer electrolytes for lithium metal batteries

Voropaeva D., S. Novikova, I. Stenina et al., Solid State Ionics 2026 Vol. 445 Article 117288

Composite gel polymer electrolytes based on a perfluorinated sulfonic acid cation-exchange MF-4SC membrane containing surface-sulfonated nanoparticles of aluminum oxide, cerium (IV) oxide, and titanium oxide (sAl2O3, sCeO2, and sTiO2, respectively) were prepared by casting from a dispersion in N,N-dimethylformamide and plasticized with a 1,3-dioxolane/1,2-dimethoxyethane mixture. The influence of the filler nature on ionic conductivity, solvent uptake, activation energy, lithium ...

Added: July 30, 2026

Three-dimensional magnetization textures as quaternionic functions

Metlov K., Andrei B. Bogatyrëv, Annalen der Physik 2026 Vol. 538 No. 6 Article e70234

Thanks to the recent progress in bulk full three-dimensional nanoscale magnetization distribution imaging, there is a growing interest to three-dimensional (3D) magnetization textures, promising new high information density spintronic applications. Compared to 1D domain walls or 2D magnetic vortices/skyrmions, they are a much harder challenge to represent, analyze and reason about. Here we build analytical representation for such ...

Added: July 28, 2026

A simplified approach to predicting thermal expansion anisotropy of solids from first principles: application to the orthorhombic phase of Mo2C

Dmitry Vasilyev, Gorev V., Ikhsanov R. et al., Journal of Materials Science 2026 No. 61 P. 25452–25470

The orthorhombic phase of 𝛼-Mo2 C is a key component in electrocatalytic applications, as Mo2C-based catalysts can exhibit catalytic performance comparable to or exceeding that of noble metals. Despite its technological relevance, theoretical understanding of the anisotropy in the thermal expansion and related thermoelastic properties of 𝛼-Mo2 C remains limited. In this work, first-principles calculations ...

Added: July 23, 2026

Influence of Pulsed Laser Radiation on the Morphology and Surface Properties of Tungsten Implanted with Helium Ions

Borovitskaya I. V., Pimenov V. N., Korshunov S. N. et al., Physics of Atomic Nuclei 2026 Vol. 89 No. 1 P. S48–S55

The effect of high-power pulsed laser radiation (LR) generated in the GOS 1001 setup in the Q-modulated mode (with a flux power density q equal to 1 × 1014 W/m2, pulse duration t = 50 ns, and the number of pulses N from 1 to 8 in vacuum) on the structure and microhardness of the surface of ...

Added: July 22, 2026

Long-range machine-learning potentials with environment-dependent charges enable predicting LO-TO splitting and dielectric constants

Korogod D., Shapeev A., Ivan S. Novikov, Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 114 No. 2 Article 024104

We present two models with explicit long-range electrostatics in the form of Coulomb interactions. Both models include point charges depending on their local atomic environments, and the second model also conserves a total charge of an atomic system. We combine the proposed long-range models with the local moment tensor potential (MTP) and demonstrate that they ...

Added: July 22, 2026

Global optimization of atomic clusters via physically constrained tensor train decomposition

Sozykin K., Rybin N., Chertkov A. et al., Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 113 No. 22 Article 224111

The global optimization of atomic clusters represents a fundamental challenge in computational chemistry and materials science due to the exponential growth of local minima with system size (i.e., the curse of dimensionality). We introduce a framework that overcomes this limitation by exploiting the low-rank structure of potential energy surfaces through tensor train (TT) decomposition. Our ...

Added: July 22, 2026

New bound on S1× S2-setting Bell locality of a nonseparable Werner state

Loubenets E. R., / Series arxiv.org "quant-ph". 2026. No. 2607.18050.

In many quantum applications it is important to know whether or not a Bell nonlocal two-qudit state exhibits its nonlocality under correlation scenarios with some given numbers S1,S2≥1 of generalized quantum measurements at two sites. In the present article, we find analytically a new general locality condition sufficient for a nonseparable Werner state with a ...

Added: July 21, 2026

Optimal navigation in two-dimensional flows: Control theory and reinforcement learning

Parfenyev V., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 No. 1 Article 015104

Zermelo's navigation problem seeks the trajectory of minimal travel time between two points in a fluid flow. We address this problem for an agent -- such as a floating drone or active particle -- that is advected by a two-dimensional flow, self-propels at a fixed speed smaller than or comparable to the characteristic flow velocity, ...

Added: July 17, 2026

Matrix Kadomtsev—Petviashvili Hierarchy and Spin Generalization of Trigonometric Calogero—Moser Hierarchy

Prokofev V., Zabrodin A., Proceedings of the Steklov Institute of Mathematics 2020 Vol. 309 P. 225–239

We consider solutions of the matrix Kadomtsev-Petviashvili (KP) hierarchy that are trigonometric functions of the first hierarchical time t1 = x and establish the correspondence with the spin generalization of the trigonometric Calogero-Moser system at the level of hierarchies. Namely, the evolution of poles xi and matrix residues at the poles aαibβi of the solutions with respect to the kth hierarchical time of the ...

Added: July 14, 2026

Elliptic solutions of the Toda lattice hierarchy and the elliptic Ruijsenaars–Schneider model

Prokofev V., Zabrodin A., Theoretical and Mathematical Physics 2021 Vol. 208 P. 1093–115

We consider solutions of the 2D Toda lattice hierarchy which are elliptic functions of the zeroth time t_0=x. It is known that their poles as functions of t_1 move as particles of the elliptic Ruijsenaars-Schneider model. The goal of this paper is to extend this correspondence to the level of hierarchies. We show that the ...

Added: July 14, 2026

Kink oscillation of a system of two braided magnetic flux tubes

Ruderman M. S., N. S. Petrukhin, Monthly Notices of the Royal Astronomical Society 2026 Vol. 549 No. 4 Article stag783

For the first time we study kink oscillations of braided coronal magnetic loops. We use the simplest model of a braided loop that consists just of two identical curved magnetic tubes. It is assumed that the plasma density is constant inside the tubes, and also in the surrounding plasma. To describe the kink oscillations we ...

Added: July 12, 2026

Scaling Up Molecular Hydrodynamics of Non-Laminar Flows with GPU-Aware MPI

Khnkoian G., Galigerov V., Grishichkin Y. et al., , in: Parallel Computational Technologies, 19th International Conference, PCT 2025, Moscow, Russia, April 8–10, 2025, Revised Selected Papers. (CCIS, volume 2891)Vol. 2891.: Springer, 2026. P. 532–545.

This work presents atomic-scale modeling of the perturbed flow of a Lennard-Jones fluid in a quasi-two-dimensional system containing one billion atoms. A statistically stationary flow regime corresponding to a Reynolds number of Re ≈ 1000 has been achieved, the flow structure has been analyzed, and the energy spectrum of velocities has been calculated. The results ...

Added: May 19, 2026

MDProcessing.jl: Julia Programming Language Application for Molecular Dynamics Trajectory Processing

Pisarev V., Panov M., , in: Supercomputing: 9th Russian Supercomputing Days, RuSCDays 2023, Moscow, Russia, September 25–26, 2023, Revised Selected Papers, Part II* 2.: Springer, 2023. P. 209–222.

Molecular simulations and molecular dynamics in particular are among the most performance-demanding computational methods. As the scale of simulations increases, the task of processing the simulation results becomes a computationally-hungry problem as well. The usual approach to build easy-to-use post-processing tools is based on providing an interface to a high-performance library called from a scripting ...

Added: November 11, 2025

Immune Antibodies Recognizing the Stem Region of SARS-CoV-2 Spike Protein: Molecular Modelling and In Vitro Study of Synthetic Peptides Presentation to the Antibodies

Aliper E., Ryzhov I., Obukhova P. et al., Biochimica et Biophysica Acta - Biomembranes 2026 Vol. 1868 No. 1 Article 184472

Antibodies to peptide 1147 (amino acids 1147-61) of the SARS-CoV-2 protein S are highly diagnostic. Peptide 1147, although located in a region that is partly spatially hidden in the intact protein, is not subject to mutations, suggesting therapeutic potential. The aim of this study was to elucidate the architecture of this region and the way ...

Added: October 20, 2025

Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment

Volynsky P., Urban A., Pavlov K. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 2 Article 553

Alzheimer’s disease (AD) pathogenesis is correlated with the membrane content of various lipid species, including cholesterol, whose interactions with amyloid precursor protein (APP) have been extensively explored. Amyloid-β peptides triggering AD are products of APP cleavage by secretases, which differ depending on the APP and secretase location relative to ordered or disordered membrane microdomains. We used high-resolution NMR to probe ...

Added: October 12, 2025

Effect of the Cut-Off Radius of the Interatomic Potential on the Surface Tension of n-Nonane in the SAFT-γ Mie Model

Smirnov O. M., Pisarev V., Lenev D. Y., Russian Journal of Physical Chemistry A 2024 Vol. 98 No. 14 P. 3384–3388

Vapor–liquid surface tension is calculated on the evaporation curve of n-nonane in the SAFT-γ Mie model. The calculations are made via molecular dynamics for temperatures in the range of 410 to 505 K. The effect the cutoff radius of the interparticle interaction potential in the model has on the coefficient of surface tension and the ...

Added: June 25, 2025