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August 25, 2026
Scientists Develop Algorithm for More Reliable Processors in Data Centres
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Influence of the lipid composition of lipid droplets on the efficiency of their protein-free fusion

Biophysical Reviews. 2023. Vol. 15. Article 1505.
Senchikhin I., Urodkova E. K., Minkevich M. M., Denieva Z. G., Molotkovsky R. J.

The work is dedicated to the study of the fusion of lipid droplets — organelles consisting of a core of fatty acids, such as triolein, surrounded by a monolayer of phospholipids. In view of the relatively simple implementation and universality of the effect of the lipid composition of the LC membranes on the efficiency of their fusion, a targeted change in the lipid composition seems to be a convenient tool for promising therapy of diseases associated with metabolic disorders.

As part of the work, we studied the protein-free fusion of lipid droplets, leading to the unification of their monolayer shells. This process requires overcoming the energy barrier E associated with the topological rearrangement of merging lipid monolayers. We have evaluated the energy barrier and studied the effect of lipid composition on the height of this barrier.

Research target: Chemistry Physics Nanotechnologies
Language: English
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Keywords: molecular dynamicsDLSlipid dropletstheory of elasticity of lipid membranes
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