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October 1, 2026
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Researchers from HSE University’s Institute for Cognitive Neuroscience have synthesised the findings of their previous studies on brain development in children with obstetric brachial plexus palsy and arthrogryposis. Their analysis shows that impaired motor function in early childhood not only limits children’s motor experience but also affects memory, categorical thinking, and information processing. The study has been published in Frontiers in Psychology.
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Influence of the lipid composition of lipid droplets on the efficiency of their protein-free fusion

Biophysical Reviews. 2023. Vol. 15. Article 1505.
Senchikhin I., Urodkova E. K., Minkevich M. M., Denieva Z. G., Molotkovsky R. J.

The work is dedicated to the study of the fusion of lipid droplets — organelles consisting of a core of fatty acids, such as triolein, surrounded by a monolayer of phospholipids. In view of the relatively simple implementation and universality of the effect of the lipid composition of the LC membranes on the efficiency of their fusion, a targeted change in the lipid composition seems to be a convenient tool for promising therapy of diseases associated with metabolic disorders.

As part of the work, we studied the protein-free fusion of lipid droplets, leading to the unification of their monolayer shells. This process requires overcoming the energy barrier E associated with the topological rearrangement of merging lipid monolayers. We have evaluated the energy barrier and studied the effect of lipid composition on the height of this barrier.

Research target: Chemistry Physics Nanotechnologies
Language: English
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Keywords: molecular dynamicsDLSlipid dropletstheory of elasticity of lipid membranes
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