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Модуляторы сигнального пути Nrf2 усиливают цитотоксический эффект стандартных химиотерапевтических препаратов на органоиды метастатического колоректального рака
Клеточные технологии в биологии и медицине. 2023. № 4. С. 283–288.
The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The effect of modulators has been studied both as monotherapy and in combination with standard chemotherapy drugs used to treat colorectal cancer. The Nrf2 inhibitor brusatol and the Nrf2 activator bardoxolone have antitumor activity. Moreover, bardoxolone and brusatol also significantly enhance the effect of the chemotherapy drugs 5-fluorouracil, oxaliplatin and the irinotecan metabolite SN-38. Thus, bardoxolone and brusatol can be considered promising candidates for further preclinical and clinical studies in the treatment of colorectal cancer.
Gerges M., Kosonogov V., OBM Neurobiology 2025 Vol. 9 No. 4 Article 310
Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims ...
Added: May 12, 2026
Feurra M., Perevoznyuk G., Ragimova A. et al., Scientific Reports 2026 No. 16 Article 13098 (2026)
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Мачинская Р. И., Журнал высшей нервной деятельности им. И.П. Павлова 2025 Т. 75 № 2 С. 170–188
The review provides an analysis of modern cognitive psychological theories of emotions and neural basis
of mechanisms standing behind retention of emotional information in working memory. The tendency seen
in modern neurocognitive theories is characterized by the rejection of localization for any psychological
functions in favor of network models, where higher-order processes are supported by distributed neural
networks connecting ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590
Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
S. V. Nikulin, Olkhovik D., A.V. Razumovskaya et al., Doklady Biochemistry and Biophysics 2026
A novel trend in anticancer therapy is based on the combination of cytotoxic and metabolic drugs. Bach1 is a transcription factor activating glycolysis and increasing proliferation and metastatic potential in cancer cells. The cytotoxic effect was evaluated for a combination of rotenone, an inhibitor of mitochondrial respiration, and two different inhibitors of Bach1 transcription factor ...
Added: April 13, 2026
Pechenkova E., Паникратова Я. Р., Королькова О. А. et al., Вестник рентгенологии и радиологии 2025 Т. 106 № 6 С. 192–206
Background. Individual activation maps based on brain functional magnetic resonance imaging (fMRI) data cannot yet be applied to refine a patient's diagnosis and prognosis. However, tracking activation dynamics in the same patient during the course of treatment or rehabilitation can be useful for assessing their efficacy. Population-based studies often fail to identify clinically significant activation parameters ...
Added: April 2, 2026
Medvedeva A., Nikita Rudenkiy, Danila Shelepenkov et al., Behavioural Brain Research 2026 Vol. 507 Article 116169
Emotion regulation is aimed to control emotional states through various strategies, among which reappraisal and suppression have been extensively studied up to date. Nevertheless, physiological correlates of this process are still debatable, since findings on both brain and peripheral activity are contradictory. In the present work, we were first to investigate neural sources and inter-subject ...
Added: April 1, 2026
Леонтьева А. С., Эрлих В. Р., Ерёменко К. Ю. et al., История, археология и этнография Кавказа 2025 Т. 21 № 1 С. 124–140
This paper reports on a proto-Maeotian burial complex of a horseman warrior discovered in 2023 in the foothills of Adygea (N 44.22787800, E 40.12983900). The burial assemblage included weaponry, notably an axe-scepter, a Colchian fibula, an equine skeleton, and a set of bronze horse bridles contemporary with the Novocherkassk treasure. Based on these findings, the ...
Added: March 26, 2026
Yanova M., Maltseva D., Tonevitsky A., Frontiers in Cell and Developmental Biology 2025 Vol. 13 Article 1720996
Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Tumor sidedness, distinguishing left- (LCRC) and right-sided (RCRC) cancers, has emerged as a critical clinical determinant, influencing patient prognosis and therapeutic response. However, the cellular and molecular mechanisms underlying these differences remain poorly understood. Recent advances in single-cell RNA sequencing ...
Added: December 12, 2025
Raigorodskaya M., Novosad V., Tonevitskaya S. et al., Applied Biochemistry and Microbiology 2022 Vol. 58 No. 9 P. 992 – 996
The expression profile of CD44 isoforms in 55 colorectal cancer (CRC) cell lines has been evaluated based on mRNA sequencing data from the Cancer Cell Line Encyclopedia database. The distribution of CD44 mRNA isoforms differs significantly between CRC lines. In 13 studied lines, including Caco-2 and RKO, CD44 expression was not detected. In most other ...
Added: September 1, 2025
Alexandra Razumovskaya, Maria Silkina, Poloznikov A. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1531175
Colorectal cancer is characterized by an extremely high mortality rate, mainly caused by the high metastatic potential of this type of cancer. To date, chemotherapy remains the backbone of the treatment of metastatic colorectal cancer. Three main chemotherapeutic drugs used for the treatment of metastatic colorectal cancer are 5-fluorouracil, oxaliplatin and irinotecan which is metabolized ...
Added: January 13, 2025
D. M. Olkhovik, M. O. Silkina, A. V. Razumovskaya et al., Doklady Biochemistry and Biophysics 2025 Vol. 520 P. 25–28
Ferroptosis is an iron-dependent form of programmed cell death (PCD) associated with lipid membrane peroxidation. It has gained attention in cancer research because some tumor cells that are resistant to other forms of PCD are sensitive to ferroptosis. Despite the significant amount of research on ferroptosis, the list of known inducers remains limited, creating opportunities ...
Added: October 31, 2024
Nikulin S., Silkina M., Razumovskaya A. et al., Онкоурология 2024 Т. 20 № 1 С. 44–51
Background. Analyzing the sensitivity of patient-derived tumor organoids to anti-cancer medications shows great potential for tailoring personalized treatment plans.
Aim. To obtain two prostate tumor organoid cultures, optimize the composition of culture medium, and to evaluate the efficacy of the chemotherapeutic drug docetaxel using the obtained organoid cultures.
Materials and methods. The initial tissue was dissociated using ...
Added: May 18, 2024