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Non-invasive Brain Stimulation with a Monophasic TMS Pulse: A Pilot Study of BDNF (rs6265) and COMT (rs4680) Gene Polymorphisms
Brain Stimulation. 2023. Vol. 16. No. 1. P. 278–278.
Our goal was to evaluate genetic and gender differences in motor threshold (MT) using monophasic single pulse Transcranial Magnetic Stimulation (TMS).
Methods. In this pilot study, we used TMS over dominant primary motor cortex and recorded motor evoked potentials (MEP) from the contralateral which yielded a higher MT than other TMS methods. We applied the monophasic stimulation to evaluate phenomena of intracortical excitation and inhibition of neuromuscular activity within the upper limb muscles. 112 volunteers (age: mean/max/min 23/41/18 years; 63 females).
Results. The presence of a relatively high MT value (92-100% of the amplitude on the TMS stimulator, or not any MEP) that was revealed for 61 participants (54.4%); this is essential for future planning of experimentаl and clinical investigations. We have not found a significant relationship between BDNF (rs6265) and COMT (rs4680) gene polymorphisms and MT value (Kruskal-Wallis test, 6 subgroups polymorphism p=0.696). Also, we did not find a significant difference in the value of MT in men and women (Mann-Whitney test, p=0.279).
On the next step we have decided to apply statistical analysis of MT, candidate genes and non-brain structures based on the sMRI scans. This will allow an assessment of the contribution of extra-axial structures to the somatotopy of the processes of excitation and inhibition of the motor cortex of the brain, along with an assessment of (a) their relationship with the individual amplitude (MT) to select the optimal level of stimulation; and (b) the contribution of the genetic factor.
Conclusion. We did not find significant relationships between BDNF and СOMT polymorphisms, as well as gender and MT level. We plan further tasks to evaluate the effect of extra-axial structures on MT levels.
Publication based on the results of:
Kotov A. A., Матушкина В., Котова Т. Н., Современная зарубежная психология 2026 Т. 15 № 2 С. 111–119
Контекст и актуальность. В обзоре рассматривается эффект выученного невнимания (трудности в обраще-нии внимания на информацию, которая ранее была нерелевантной) на примере категориального науче-ния. Цель теоретического обзора: сформулировать основные этапы изучения данного эффекта, обозначитьключевые работы, объясняющие факторы, влияющие на данный эффект (фактор задачи и семантическойнагруженности). Результаты. Приводятся доказательства того, что эффект рассматривается в настоящеевремя в разных ...
Added: October 1, 2026
Kotov A. A., Зайцева Е. С., Новые психологические исследования 2026 № 3 С. 35–54
Эффект категориальной различимости выражается во влиянии окружения целевого объекта при его запоминании: эффективность запоминания целевого объекта выше в условии его окружения объектами из той же суперординатной категории, к которой он относится, чем объектами из другой суперординатной категории.
Целью исследования было изучение эффекта категориальной различимости в условиях различной загрузки рабочей памяти – вербальной и визуальной.
Категориальная репрезентация играет ...
Added: October 1, 2026
Латыпов А. Ф., Психология и право 2026 Т. 16(3) № 3 С. 259–272
Abstract Context and relevance. The simultaneous presence of three to five age cohorts within a single organizational space makes intergenerational tension in contemporary organizations increasingly systemic, raising the need for a theoretical understanding of the nature and mechanisms of intergenerational conflicts. Objective. The article aims to provide a theoretical analysis of the phenomenon of intergenerational ...
Added: September 30, 2026
Dvoinin A., Развитие личности 2025 № Спецвыпуск С. 17–20
The article outlines A.M. Dvoinin’s personal reminiscences of his teacher, the prominent psychologist Valeria Sergeevna Mukhina ...
Added: September 30, 2026
Dvoinina V. K., Dvoinin A., Natural Systems of Mind 2026 Vol. 6 No. 3 P. 18–38
Background and research problem. The prevalence of epistemically unwarranted beliefs makes it critically important to study human cognitive capacities to resist indoctrination by pseudoscientific, conspiracist, and paranormal doctrines. The research problem addressed the question of whether cognitive abilities and rationality protect against susceptibility to epistemically unwarranted beliefs. Objective. To present a theoretical analysis of contemporary ...
Added: September 30, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Сапожникова М. А., Новые психологические исследования 2026 № 3 С. 115–134
Russian psychology lacks validated instruments for the comprehensive assessment of commitment in romantic relationships. Existing measures primarily focus on relationship satisfaction while overlooking key determinants of relationship stability, such as accumulated investments and the perceived quality of alternatives, as conceptualized in Caryl Rusbult’s Investment Model.
The objective was to adapt and psychometrically validate the Russian-language version of the ...
Added: September 29, 2026
Akhmedjanova D., М.: Издательский дом НИУ ВШЭ, 2026.
Восемнадцатый выпуск серии учебно-методических пособий «Подготовка профессионалов для нового образования» посвящен преподаванию курса по метакогнитивной регуляции обучения на магистерской программе «Педагогическое образование» Института образования НИУ ВШЭ. Пособие систематизирует современные знания о природе, диагностике и развитии саморегуляции в образовании и призвано восполнить дефицит качественных русскоязычных публикаций, интегрирующих достижения отечественной научной школы и передовые международные исследования. Пособие ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Karpychev V., Malyutina S., Dragoy O., Brain Structure and Function 2026 Vol. 231 Article 69
Language comprehension and production are predominantly supported by the left-lateralized language-related network (LRN). However, right-hemispheric homologs of the language regions can also contribute to language processing, resulting in reduced left-hemispheric language lateralization. To date, it remains unclear whether less left-hemispheric language lateralization is associated with the recruitment of other non-language networks and their interaction with ...
Added: September 28, 2026
Аверьянова Варвара Андреевна, Sherbakova O., Вопросы психолингвистики 2022 Т. 53 № 3 С. 42–61
The article presents the results of the research aimed at building the framework for in-depth analysis of comprehension of implicit meanings in verbal texts. The existing approaches to studying implicit meanings and text comprehension are described, and common features of the cognitive processes underlying text comprehension are highlighted to provide the basis for further research. ...
Added: September 28, 2026
Sherbakova O., Обольская В. А., Вопросы психолингвистики 2023 Т. 55 № 1 С. 112–127
The article describes the second part of the research aimed at developing the framework for studying the comprehension of implicit meanings of verbal texts. The uniqueness of the proposed framework stems from the combination of psychological and linguistic methodologies. We outline the current approaches to the phenomenon of text comprehension along with its classifications available ...
Added: September 28, 2026
Sherbakova O., Обольская В. А., Культурно-историческая психология 2024 Т. 20 № 4 С. 31–39
The article describes an interdisciplinary framework which we have developed to study verbal text comprehension based on a combination of psychological and linguistic approaches. The comprehension phenomenon is considered to be a result of a reversible transformation between verbal symbols and mental images of the to-be-comprehended material, with the obligatory condition of preserving its semantic ...
Added: September 28, 2026
Leontiev D., Психологический журнал 2025 Т. 46 № 6 С. 146–150
Статья рассматривает последние десятилетия истории мировой и отечественной психологии через призму введенного автором понятия «закрытый перелом» начала 1970-х гг., под которым понимается ранее не описанная веха в истории мировой психологии. Под влиянием целой совокупности причин на этом рубеже наблюдается ряд тектонических изменений, относящихся как к социальной и организационной структуре научного сообщества, так и к методологии, ...
Added: September 27, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Davydova A., Sheronova J., Kosonogov V. et al., Journal of Visualized Experiments 2025 No. 226 Article e67500
Transcranial magnetic stimulation (TMS) is a powerful method for revealing causal links between specific brain regions and cognitive functions. While offline TMS has traditionally dominated cognitive neuroscience research, online repetitive TMS (rTMS) presents undoubted advantages, enabling stimulation concurrent with task performance. Leveraging advancements in this stimulation method, the study introduces a novel online rTMS protocol ...
Added: December 19, 2025
Volodina M., Ossadtchi A., Makarova M. et al., В кн.: Когнитивная наука в Москве: новые исследования. Материалы конференции 25 – 26 июня 2025.: М.: Буки Веди, 2025.
It is known that the motor cortex exhibits increased excitability during the systolic phase of the cardiac cycle (Al et al., 2023). Previous studies have shown that self-observation can enhance interoceptive sensitivity (Ainley et al., 2012). We hypothesized that visual stimuli enhancing bodily awareness could influence the relationship between the phase of the cardiac cycle and ...
Added: September 9, 2025
Makarova M., Некрасова Ю. Ю., Fedosov N. et al., Brain Stimulation 2025 Vol. 18 No. 1 P. 495
Сortico-spinal neuron excitability can be tracked using rhythmic oscillations whose phase plays a pivotal role in assessing the state of the pertinent neural network. Brain’s oscillatory activity can be non-invasively registered with electroencephalography (EEG) and magnetoencephalography (MEG). Using transcranial magnetic stimulation (TMS) contingent upon the parameters of the ongoing brain activity was shown to have numerous applications in both research and clinics. Despite the potential, the described closed-loop ...
Added: September 8, 2025
W. Joseph MacInnes, Zhozhikashvili N., Feurra M., , in: First International Conference, AIiH 2024, Swansea, UK, September 4–6, 2024, Proceedings, Part II. Artificial Intelligence in Healthcare. LNCS, volume 14976Vol. 14976.: Springer, 2024. P. 221–234.
Convolutional Neural Networks (CNNs) match human performance in many visual tasks like the classification of images, however they may not simulate the underlying biological processes. We implemented a CNN to try replicate results from an object inversion experiment with Transcranial Magnetic Stimulation (TMS). After training on upright faces, the CNN model went through three stages ...
Added: January 28, 2025
Астафьева Д. С., Власов Я. В., Стрельник А. И. et al., Нервно-мышечные болезни 2023 Т. 13 № 2 С. 20–30
По общемировым данным, нейропатическая боль встречается у 7 % населения и в 57-65 % случаев сопровождается коморбидной депрессией, что, в свою очередь, усугубляет течение болезни и ухудшает качество жизни пациентов. Ритмическая транскраниальная магнитная стимуляция (рТМС) представляет собой неинвазивный нефармакологический метод терапии депрессии, также способный помочь пациентам облегчить восприятие нейропатической боли. Представлен обзор результатов применения протоколов ...
Added: March 6, 2024
Fedosov N., Julia Nekrasova, Makarova M. et al., , in: 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), 28-30 Sept. 2023.: IEEE, 2023. P. 189–195.
The paper introduces a novel hardware-software complex for the low latency real time phase-dependent transcranial
magnetic stimulation (TMS) neurofeedback. The software with key elements implemented on the board of the EEGrecording device accurately tracks the sensorimotor rhythm phase with minimal time-delay and immediately sends the trigger to the TMS-device. An accurate phase estimation is achieved by ...
Added: December 7, 2023
A. G. Davydova, J. P. Sheronova, V. V. Kosonogov et al., Neuroscience and Behavioral Physiology 2023 Vol. 53 No. 2 P. 247–256
The theory of cognitive dissonance (CD) is tightly linked with studies of the process of making complex decisions. In particular, CD is manifest within the framework of the “free choice paradigm” consisting of reassessment of alternatives as a result of choosing between two similar alternatives via the motivation to reduce internal conflict. The mechanisms of ...
Added: April 18, 2023
Rossi S., Santarnecchi E., Feurra M., Handbook of Clinical Neurology 2022 Vol. 184 P. 239–247
Recent technological advances in the field of noninvasive brain stimulation (NIBS) have allowed to interact with endogenous brain oscillatory activity, the main neural communication code of our brain, opening new scenarios for transient modifications of cognitive and behavioral performances: such a possibility can be capitalized both for research purposes in subjects healthy, as well as ...
Added: October 29, 2022
IEEE, 2022.
The theory of cognitive dissonance suggested by Leon Festinger (1957) relies on the psychological observations of the inconsistency between people’s choice and actions and proposes that the conflict between choice and actions causes the internal conflict named cognitive dissonance, which leads to the potential modification of the behavior or attitudes to reduce or eliminate this ...
Added: October 24, 2022