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Ингибитор деметилаз семейства KDM5 — KDOAM-25 — снижает проникновение псевдотипированных вирусных частиц SARS-CoV-2 в клетки
Клеточные технологии в биологии и медицине. 2023. № 1. С. 40–46.
We studied the effect of KDM5 family demethylase inhibitors (JIB-04, PBIT, and KDOAM-25) on the penetration of SARS-CoV-2 pseudotyped viruses into differentiated Caco-2 cells and HEK293T cells with ACE2 hyperexpression. The above drugs were not cytotoxic. Only KDOAM-25 significantly reduced viral entry into cells. At the same time, the level of ACE2 mRNA expression in Caco-2 significantly increased, while TMPRSS2 expression did not significantly change. In differentiated Caco-2 cells KDOAM-25 did not affect the expression of BRCA1, CDH1, TP53, SNAI1, VIM, and UGCG genes, for which an association with knockdown or overexpression of KDM5 demethylases or the action of demethylase inhibitors had previously been shown. However, BRCA1, SNAI1, VIM, and CDH1 expression was significantly increased in undifferentiated Caco-2 cells under the action of KDOAM-25.
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Bessonova E., Popova S., Fedulova M., Emerging Markets Review 2026 Vol. 75 Article 101564
To mitigate the shocks caused by the pandemic-related restrictions, many governments implemented extensive support measures for companies facing sharp declines in revenues. In Russia, loan guarantee programmes allowed many firms to apply for loans during the pandemic. As a result, the number of small loans soared. Participation in the loan guarantee programmes helped firms in ...
Added: October 8, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Артёменко В. Г., Проблемы прогнозирования 2026 № 1 С. 144–156
The article analyzes the adaptation of the ICT specialist labor market in Russia in the context of technological development and external shocks in the first half of the 2020s. Against the backdrop of a general increase in the number of ICT specialists in Russia, external shocks changed the balance of supply and demand in the labor market. In ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
ARUTYUNOV G. P., TARLOVSKAYA E. I., POLYAKOV D. S. et al., Heliyon 2024 Vol. 10 No. 7 Article e28892
The aim of this study is to investigate the course of the acute period of COVID-19 and devise a prognostic scale for patients hospitalized.
Materials and methods
The ACTIV registry encompassed both male and female patients aged 18 years and above, who were diagnosed with COVID-19 and subsequently hospitalized. Between June 2020 and March 2021, a total ...
Added: September 28, 2026
Новосибирск: ИПЦ НГУ, 2025.
This edition represents the publications of the 63rd International Scientific Student Conference 2025 (ISSC-2025) theses in in oriental studies and ethnography.
These Conference materials can be of interest for students, Ph.D. candidates, professors, scientists, and members of educational institutions. ...
Added: September 26, 2026
Lin Z., Duan K., Wan R. et al., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Burkova V., Butovskaya M., , in: Principles and Forms of Sociocultural Organization: Historical Contexts of Interaction.: L., NY: Anthem Press, 2026. Ch. 12 P. 237–250.
Cross-cultural psychology and anthropology have many ways of studying human cultures in all their diversity. There are multiple theories of cultural dimensions which provide a foundation for understanding how a culture of a given society influences individual values within it and how these values shape individual behavior. The chapter presents several examples of such classifications ...
Added: September 24, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Васильчук М. С., Шаньков Ф. М., Chumakova M. et al., Psychology. Journal of the Higher School of Economics 2021 Vol. 18 No. 2 P. 247–258
The 2019 Coronavirus disease outbreak leads to negative psychological outcomes not only for healthcare workers and patients, but also for the general public. S. Hobfoll’s Conservation of Resources theory is one of the most applicable models for conceptualizing and evaluating natural and social catastrophes and their impact. A web-based screening has been conducted at the ...
Added: June 30, 2026
Levin J., Oprea T. I., Davidovich S. et al., Nature Biotechnology 2020 P. 1127–1131
The COVID-19 pandemic has transformed the way scientific and clinical results are shared and disseminated. According to a recent analysis, an average of 367 COVID-19 papers are being published every week, with a median time from submission to acceptance of just 6 days (compared with 84 days for non-COVID-19 content)1. These unprecedented peer review turnaround ...
Added: June 1, 2026
Dvoynikova A., Маркитантов М. В., Рюмина Е. В. et al., Информатика и автоматизация (Труды СПИИРАН) 2021 Т. 20 № 5 С. 1116–1152
Начиная с 2019 года все страны мира столкнулись со стремительным распространением пандемии, вызванной коронавирусной инфекцией COVID-19, борьба с которой продолжается мировым сообществом и по настоящее время. Несмотря на очевидную эффективность средств индивидуальной защиты органов дыхания от заражения коронавирусной инфекцией, многие люди пренебрегают использованием защитных масок для лица в общественных местах. Поэтому для контроля и своевременного ...
Added: April 24, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2024 Т. 4 № 4 С. 4–15
Introduction. The study is devoted to the analysis of the dynamics of the tobacco and alcohol use prevalence among the adult population during the COVID-19 pandemic.
The purpose of the study: to analyze the impact of the COVID-19 pandemic on the prevalence of tobacco and nicotine-containing products consumption among the adult population of the Russian Federation, men and ...
Added: April 9, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2022 Т. 2 № 2 С. 29–39
The fight against the COVID‑19 pandemic has led to the implementation of unprecedented measures in countries, including self-isolation, which have had a significant impact on people’s behavior and could lead to a change in the consumption of tobacco and nicotine-containing products. This article provides an overview of studies evaluating smoking behavior change and its impact ...
Added: April 9, 2026
Islentyeva Anna, Scheffler T., Discourse and Communication 2024 Vol. 18 No. 2 P. 216–243
This paper represents a comparative study that explores the governmental vaccine advertising campaigns that were authorised by two English-speaking and two German-speaking countries – namely Australia, Britain, Austria and Germany – within the context of the global SARS-CoV-2 pandemic. The data set in question comprises 40 vaccination posters issued by each country’s respective government between ...
Added: March 9, 2026
Bilqis L. C., Shishkina A., Journal of Globalization Studies 2025 Vol. 16 No. 2 P. 169–179
This article is devoted to the study of the phenomenon of digital nomadism in the period after the onset of the COVID-19 pandemic, which has accelerated the trend on transformation of many aspects of life, including labor market, due to digitalization. The authors discuss the significance of this phenomenon in the context of the intensified ...
Added: February 25, 2026