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Ингибитор деметилаз семейства KDM5 — KDOAM-25 — снижает проникновение псевдотипированных вирусных частиц SARS-CoV-2 в клетки
Клеточные технологии в биологии и медицине. 2023. № 1. С. 40–46.
We studied the effect of KDM5 family demethylase inhibitors (JIB-04, PBIT, and KDOAM-25) on the penetration of SARS-CoV-2 pseudotyped viruses into differentiated Caco-2 cells and HEK293T cells with ACE2 hyperexpression. The above drugs were not cytotoxic. Only KDOAM-25 significantly reduced viral entry into cells. At the same time, the level of ACE2 mRNA expression in Caco-2 significantly increased, while TMPRSS2 expression did not significantly change. In differentiated Caco-2 cells KDOAM-25 did not affect the expression of BRCA1, CDH1, TP53, SNAI1, VIM, and UGCG genes, for which an association with knockdown or overexpression of KDM5 demethylases or the action of demethylase inhibitors had previously been shown. However, BRCA1, SNAI1, VIM, and CDH1 expression was significantly increased in undifferentiated Caco-2 cells under the action of KDOAM-25.
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged
perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase
plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular
remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and
perivascular fibrosis, ...
Added: May 19, 2026
Gerges M., Kosonogov V., OBM Neurobiology 2025 Vol. 9 No. 4 Article 310
Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims ...
Added: May 12, 2026
Feurra M., Perevoznyuk G., Ragimova A. et al., Scientific Reports 2026 No. 16 Article 13098 (2026)
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Dvoynikova A., Маркитантов М. В., Рюмина Е. В. et al., Информатика и автоматизация (Труды СПИИРАН) 2021 Т. 20 № 5 С. 1116–1152
Начиная с 2019 года все страны мира столкнулись со стремительным распространением пандемии, вызванной коронавирусной инфекцией COVID-19, борьба с которой продолжается мировым сообществом и по настоящее время. Несмотря на очевидную эффективность средств индивидуальной защиты органов дыхания от заражения коронавирусной инфекцией, многие люди пренебрегают использованием защитных масок для лица в общественных местах. Поэтому для контроля и своевременного ...
Added: April 24, 2026
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Мачинская Р. И., Журнал высшей нервной деятельности им. И.П. Павлова 2025 Т. 75 № 2 С. 170–188
The review provides an analysis of modern cognitive psychological theories of emotions and neural basis
of mechanisms standing behind retention of emotional information in working memory. The tendency seen
in modern neurocognitive theories is characterized by the rejection of localization for any psychological
functions in favor of network models, where higher-order processes are supported by distributed neural
networks connecting ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590
Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...
Added: April 15, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2024 Т. 4 № 4 С. 4–15
Introduction. The study is devoted to the analysis of the dynamics of the tobacco and alcohol use prevalence among the adult population during the COVID-19 pandemic.
The purpose of the study: to analyze the impact of the COVID-19 pandemic on the prevalence of tobacco and nicotine-containing products consumption among the adult population of the Russian Federation, men and ...
Added: April 9, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2022 Т. 2 № 2 С. 29–39
The fight against the COVID‑19 pandemic has led to the implementation of unprecedented measures in countries, including self-isolation, which have had a significant impact on people’s behavior and could lead to a change in the consumption of tobacco and nicotine-containing products. This article provides an overview of studies evaluating smoking behavior change and its impact ...
Added: April 9, 2026
Islentyeva Anna, Scheffler T., Discourse and Communication 2024 Vol. 18 No. 2 P. 216–243
This paper represents a comparative study that explores the governmental vaccine advertising campaigns that were authorised by two English-speaking and two German-speaking countries – namely Australia, Britain, Austria and Germany – within the context of the global SARS-CoV-2 pandemic. The data set in question comprises 40 vaccination posters issued by each country’s respective government between ...
Added: March 9, 2026
Bilqis L. C., Shishkina A., Journal of Globalization Studies 2025 Vol. 16 No. 2 P. 169–179
This article is devoted to the study of the phenomenon of digital nomadism in the period after the onset of the COVID-19 pandemic, which has accelerated the trend on transformation of many aspects of life, including labor market, due to digitalization. The authors discuss the significance of this phenomenon in the context of the intensified ...
Added: February 25, 2026
Trofimova N., Ананьева Ю. С., Киселева С. В. et al., Дискурс 2023 Vol. 9 No. 6 P. 161–172
Introduction. In the spring of 2020, the pandemic of coronavirus was announced in the world – the disease caused by the new type of coronavirus SARS-COV-2. In connection with the progressive psychoemotional stress in society in the literature and the media, attempts are made in a simple and affordable form to explain the causes of this disease and
prevention ...
Added: February 23, 2026
Semenova M., Loginova Y., Balsevich A. A., Pacific-Basin Finance Journal 2026 Vol. 97 Article 103118
This paper examines the effect of board gender diversity on bank performance during the COVID-19 crisis. Using a panel dataset of 173 European banks spanning the period 2010–2022, we find that the presence of female directors on bank boards is positively associated with profitability and solvency during the pandemic period. The positive impact is more ...
Added: February 22, 2026
Trofimova N., Манукян Я. А., Дискурс 2023 Т. 9 № 2 С. 156–168
Introduction. This article is devoted to the linguocultural study of humorous texts/metaphors which appeared in German during the COVID-19 pandemic. The scientific novelty of the study lies in the previously unexplored study of the linguocultural specificity of German-language humour in the context of the coronavirus pandemic. The relevance of the research is due to the ...
Added: February 22, 2026