Гарантирующее управление в задаче применения антивирусных препаратов и результаты математического моделирования
The human immunodeficiency virus infection, that causes Acquired Immune Deficiency Syndrome (AIDS), is a dynamic process that can be modeled via differential equations. The paper introduces
a methodological problem of use of modern mathematical and information methods to boost the response of the immune system by means of drug scheduling. The control purpose is to steer the system
to an equilibrium condition, known as long-term nonprogressor, which corresponds to an infected patient that does not develop AIDS symptoms. To show the feasibility of the control methodology a human
immunodeficiency virus model computer simulations are presented.
The problem of management of the nonlinear object which is exposed to impact of uncontrollable indignations, is considered in a key of differential game. Synthesis of optimum managements is made with application of transformation of the nonlinear equation of initial object in the differential equation with the parameters depending on a condition. The square-law functional of quality allows to formulate synthesis conditions in the form of need of search of solutions of the equation of Rikkati. The solution of the equation of Rikkati with the parameters depending on a condition, is in a symbolical view with application of algebraic methods that allows to generalize a number of earlier published theoretical results, to receive rather constructive decisions in a number of statements of problems of management.
A model for organizing cargo transportation between two node stations connected by a railway line which contains a certain number of intermediate stations is considered. The movement of cargo is in one direction. Such a situation may occur, for example, if one of the node stations is located in a region which produce raw material for manufacturing industry located in another region, and there is another node station. The organization of freight traﬃc is performed by means of a number of technologies. These technologies determine the rules for taking on cargo at the initial node station, the rules of interaction between neighboring stations, as well as the rule of distribution of cargo to the ﬁnal node stations. The process of cargo transportation is followed by the set rule of control. For such a model, one must determine possible modes of cargo transportation and describe their properties. This model is described by a ﬁnite-dimensional system of diﬀerential equations with nonlocal linear restrictions. The class of the solution satisfying nonlocal linear restrictions is extremely narrow. It results in the need for the “correct” extension of solutions of a system of diﬀerential equations to a class of quasi-solutions having the distinctive feature of gaps in a countable number of points. It was possible numerically using the Runge–Kutta method of the fourth order to build these quasi-solutions and determine their rate of growth. Let us note that in the technical plan the main complexity consisted in obtaining quasi-solutions satisfying the nonlocal linear restrictions. Furthermore, we investigated the dependence of quasi-solutions and, in particular, sizes of gaps (jumps) of solutions on a number of parameters of the model characterizing a rule of control, technologies for transportation of cargo and intensity of giving of cargo on a node station.
Event logs collected by modern information and technical systems usually contain enough data for automated process models discovery. A variety of algorithms was developed for process models discovery, conformance checking, log to model alignment, comparison of process models, etc., nevertheless a quick analysis of ad-hoc selected parts of a journal still have not get a full-fledged implementation. This paper describes an ROLAP-based method of multidimensional event logs storage for process mining. The result of the analysis of the journal is visualized as directed graph representing the union of all possible event sequences, ranked by their occurrence probability. Our implementation allows the analyst to discover process models for sublogs defined by ad-hoc selection of criteria and value of occurrence probability
The geographic information system (GIS) is based on the first and only Russian Imperial Census of 1897 and the First All-Union Census of the Soviet Union of 1926. The GIS features vector data (shapefiles) of allprovinces of the two states. For the 1897 census, there is information about linguistic, religious, and social estate groups. The part based on the 1926 census features nationality. Both shapefiles include information on gender, rural and urban population. The GIS allows for producing any necessary maps for individual studies of the period which require the administrative boundaries and demographic information.
It is well-known that the class of sets that can be computed by polynomial size circuits is equal to the class of sets that are polynomial time reducible to a sparse set. It is widely believed, but unfortunately up to now unproven, that there are sets in EXPNP, or even in EXP that are not computable by polynomial size circuits and hence are not reducible to a sparse set. In this paper we study this question in a more restricted setting: what is the computational complexity of sparse sets that are selfreducible? It follows from earlier work of Lozano and Torán (in: Mathematical systems theory, 1991) that EXPNP does not have sparse selfreducible hard sets. We define a natural version of selfreduction, tree-selfreducibility, and show that NEXP does not have sparse tree-selfreducible hard sets. We also construct an oracle relative to which all of EXP is reducible to a sparse tree-selfreducible set. These lower bounds are corollaries of more general results about the computational complexity of sparse sets that are selfreducible, and can be interpreted as super-polynomial circuit lower bounds for NEXP.