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News
July 16, 2026
Team Success: Aligning Means with Objectives
In corporations, sports, and academia, people often face challenges they cannot handle alone. In such cases, selecting the right team is crucial. Tatiana Mayskaya, Associate Professor at the HSE Faculty of Economic Sciences and the International College of Economics and Finance, together with colleagues from foreign universities, examined team characteristics and found that less diverse teams are better suited to objectives where a high average performance is important, whereas more diverse teams are preferable when avoiding failure is critical. The paper has been published in Economic Theory.
July 15, 2026
Economists Propose More Effective Approach to Reducing Smoking
Economists at HSE University have examined how smokers respond to changes in cigarette prices. When tobacco prices increase, cigarette consumption does not always decline. In fact, spending on tobacco may even rise: according to the researchers, a 1% decrease in cigarette affordability leads to a 0.28% increase in per capita tobacco expenditure. The findings suggest that to reduce smoking rates, tobacco prices must rise faster than household incomes. The study has been published in Voprosy Statistiki.
July 15, 2026
HSE MIEM Students to Develop Two Satellites from Scratch for Orbital Experiments
The devices, created by student teams, will conduct space research on the properties of promising solar cells, on-board energy storage systems, and serial electronics for student satellites.

 

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The Epigenetic Modulation of Cancer and Immune Pathways in Hepatitis B Virus-Associated Hepatocellular Carcinoma: The Influence of HBx and miRNA Dysregulation

Frontiers in Immunology. 2021. Vol. 12. Article 661204.
Sartorius K., An P., Winkler C., Chuturgoon A., Li X., Makarova J., Kramvis A.

Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC) pathogenesis is fueled by persistent HBV infection that stealthily maintains a delicate balance between viral replication and evasion of the host immune system. HBV is remarkably adept at using a combination of both its own, as well as host machinery to ensure its own replication and survival. A key tool in its arsenal, is the HBx protein which can manipulate the epigenetic landscape to decrease its own viral load and enhance persistence, as well as manage host genome epigenetic responses to the presence of viral infection. The HBx protein can initiate epigenetic modifications to dysregulate miRNA expression which, in turn, can regulate downstream epigenetic changes in HBV-HCC pathogenesis. We attempt to link the HBx and miRNA induced epigenetic modulations that influence both the HBV and host genome expression in HBV-HCC pathogenesis. In particular, the review investigates the interplay between CHB infection, the silencing role of miRNA, epigenetic change, immune system expression and HBV-HCC pathogenesis. The review demonstrates exactly how HBx-dysregulated miRNA in HBV-HCC pathogenesis influence and are influenced by epigenetic changes to modulate both viral and host genome expression. In particular, the review identifies a specific subset of HBx induced epigenetic miRNA pathways in HBV-HCC pathogenesis demonstrating the complex interplay between HBV infection, epigenetic change, disease and immune response. The wide-ranging influence of epigenetic change and miRNA modulation offers considerable potential as a therapeutic option in HBV-HCC.

Research target: Medical Biotechnologies Biology
Language: English
DOI
Text on another site
Keywords: microRNAhepatitis B virus-associated hepatocellular carcinomaepigenetic modulationHBx immunology
Publication based on the results of:
Creation of a metastasis-on-chip microphysiological platform for studying the biology of the tumor process (mathematical modeling) (2021)
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