Mapping of multiple muscles with transcranial magnetic stimulation: absolute and relative test–retest reliability
The spatial accuracy of transcranial magnetic stimulation (TMS) may be as small as a few millimeters. Despite such great potential, navigated TMS (nTMS) mapping is still underused for the assessment of motor plasticity, particularly in clinical settings. Here, we investigate the within-limb somatotopy gradient as well as absolute and relative reliability of three hand muscle cortical representations (MCRs) using a comprehensive grid-based sulcus-informed nTMS motor mapping. We enrolled 22 young healthy male volunteers. Two nTMS mapping sessions were separated by 5–10 days. Motor evoked potentials were obtained from abductor pollicis brevis (APB), abductor digiti minimi, and extensor digitorum communis. In addition to individual MRI-based analysis, we studied normalized MNI MCRs. For the reliability assessment, we calculated intraclass correlation and the smallest detectable change. Our results revealed a somatotopy gradient reflected by APB MCR having the most lateral location. Reliability analysis showed that the commonly used metrics of MCRs, such as areas, volumes, centers of gravity (COGs), and hotspots had a high relative and low absolute reliability for all three muscles. For within-limb TMS somatotopy, the most common metrics such as the shifts between MCR COGs and hotspots had poor relative reliability. However, overlaps between different muscle MCRs were highly reliable. We, thus, provide novel evidence that inter-muscle MCR interaction can be reliably traced using MCR overlaps while shifts between the COGs and hotspots of different MCRs are not suitable for this purpose. Our results have implications for the interpretation of nTMS motor mapping results in healthy subjects and patients with neurological conditions.
The considered model of the failure rate of CMOS VHSIC design proposed in the article Piskun G.A., Alekseev V.F., "Improvement of mathematical models calculating of CMOS VLSIC taking into account features of impact of electrostatic discharge", published in the first issue of the journal "Technologies of electromagnetic compatibility" for the year 2016. It is shown that the authors claim that this model "...will more accurately assess the reliability of CMOS VHSIC design" is fundamentally flawed and its application will inevitably lead to inadequate results. Alternatively, the proposed model of the failure rate of CMOS VHSIC design, which also allows to take into account the views of ESD, but based on the use of resistance characteristics of CMOS VHSIC to the effects of ESD.
The article considers the questions assessing the reliability of mechanical components used in the electronic equipment in the early stages of design. The calculations of failure rates springs shock absorbers according to various methods. It is shown that the use of models failure rates of mechanical elements, taking into account the peculiarities of their structural and technological performance, not only allows us to solve the problem of calculating, but also to ensure the required level of reliability and mechanical components, and containing electronic equipment.
The article is devoted to the problem of selfdisclosure of a personality as implicit readiness to active self-fulfillment. The author examines positive and negative consequences of self-disclosure in communication and studies temporal boundaries, time and relevance of self-disclosure of a person in dyadic, interpersonal and inter-group relationship.
The monograph presents results by professor Dr. A. Shalumov’s Research School of Modeling, Information Technology and Automated Systems (Russia). The program, ASONIKA, developed by the school is reviewed here regarding reliability and quality of devices for simulation of electronics and chips during harmonic and random vibration, single and multiple impacts, linear acceleration and acoustic noise, and steady-state and transient thermal effects. Calculations are done for thermal stress during changes in temperature and power in time. Calculations are done for number of cycles to fatigue failure under mechanical loads as well as under cyclic thermal effects. Simulation results for reliability analysis are taken into account. Models, software interface, and simulation examples are presented.
For engineers and scientists involved in design automation of electronics.
Mathematical models of failure rate of refusals the elements applied in calculations of reliability of the onboard electronic equipment are considered. Possibility of application the models given in foreign standards, for forecasting of reliability of completing elements is shown.
The basic influencing the factor defining its reliability are temperature influences at which speed of chemical reaction of materials a part REE increases. It is represented the equation which has been received by the Swedish chemist Svante Arreniusom from thermodynamic reasons
The monograph contents totaled the many years results of Scientific school «The Automated System for Ensuring of Reliability and Quality of Equipment - ASONIKA» National research University «Higher school of Economics» (scientific supervisor of the Scientific school - academician of RANS, doctor of technical sciences, professor YU. Kofanov) and long-term cooperation with the scientists of Kiev Institute of mathematical machines and systems problems of the Ukrainian National Sciences Academy (Deputy Director on science, doctor of technical sciences V.P. Strelnikov). The final structure of the monograph had been formed in the discussion of modern problems of reliability aerospace electronic equipment at the XVII International scientific-technical conference «Systemic problems of reliability, quality, mathematical modelling, information and infocommunication technologies in innovation projects». This conference was dedicated to the 20th anniversary of the HSE. The book outlines the basics of probability-physical approach to the study and the assessment of the reliability of onboard aerospace equipment. Presents the methods of estimation of reliability parameters of electronic components, as according to reference data and test or operating results in the presence or absence of failures. Developed the methods of calculation of reliability parameters of mechanical elements of aerospace equipment as well as research methods reliability of redundant and non-redundant, non-renewable and renewable systems on the basis of adequate two-parameter distributions of diffusion. Established the theory of planning reliability test with lightweight, durable, including accelerated testing with new methods of processing the testing results and reliability assessment. We propose new methods of evaluation and prediction of the aerospace equipment reliability to measure the determining parameters. Developed methodology of the statistical characteristics evaluation of the degradation process for the study of single samples of aerospace equipment using information about its representative minobject (minibranch, mineralizatsiya). All problems of reliability, which is solved in this book (mathematical modeling, calculation and experimental evaluation of the reliability of systems) result in the identification of the time until failure (or to failure) distribution. It is proved that when assessing the reliability of onboard aerospace equipment, most accurate results diffusion DN-distribution. On the basis of the law of distribution can be carried out the evaluation of all the necessary parameters of aerospace equipment reliability (mathematical expectations developments, gamma-interest developments, the probability of non-failure operating time for the specified time, the residual resource and others). The book provides a large number of examples and problems, proving the effectiveness and efficiency of the proposed methods. Material monograph mostly taught HSE in the various courses of lectures. The monograph is intended for a wide circle of specialists working in the field design, testing and operation of onboard aerospace equipment, as well as students and graduate students of the HSE in the execution of their coursework, independent scientific research, and the preparation of graduation theses and dissertations.
Maintenance of reliability of radio-electronic equipment taking into account thermal modes for various classes of electroradioproducts (ERP) within the limits of system ASONIKA is considered.
Statistical Models and Methods for Reliability and Survival Analysis is a volume of contributions by specialists in statistical theory and their applications that provide up-to-date developments in methods used in survival analysis, statistical goodness of fit, stochastic processes for system reliability among others. Many of them are related to the work of Professor M. Nikulin in statistics for thirty years. The contributors accepted this challenging project to gather various contributions with a wide broad of techniques and results, all of them in the topics of the past S2MRSA conference dedicated to M. Nikulin for his twentieth anniversary as a Professor in the Bordeaux Segalen University. The book is intended for researchers interested in statistical methodology and models useful in survival analysis, system reliability and statistical testing for censored and non censored data.
This prototype development explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISO/IEEE 11073 messages and to process them easily. MD act as X73 agent. Second one is focused on more powerful device X73 manager, which do not have the MDs' memory and processor usage constraints. The protocol between Agent and Manager is point-to-point and we can distribute the functionality between devices.
Developed both implementation X73 Agent and Manager will cut developing time for applications based on ISO/EEE 11073.
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine