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Article

Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms

European Journal of Organic Chemistry. 2019. Vol. 2019. No. 1. P. 32-35.
Afanasyev O., Zarochintsev A., Petrushina T., Cherkasova A., Denisov G., Cherkashchenko I., Chusova O., Oh J., Chun M., Usanov D., Semenov S., Chusov D.

A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed.