?
Consolidated mathematical growth model of the primary tumor and secondary distant metastases of breast cancer (CoMPaS)
Plos One. 2018. Vol. 13. No. 7. P. 1–16.
Ella Y Tyuryumina, Alexey A Neznanov
The goal of this research is to improve the accuracy of predicting the breast cancer (BC) pro- cess using the original mathematical model referred to as CoMPaS. The CoMPaS is the original mathematical model and the corresponding software built by modelling the natural history of the primary tumor (PT) and secondary distant metastases (MTS), it reflects the relations between the PT and MTS. The CoMPaS is based on an exponential growth model and consists of a system of determinate nonlinear and linear equations and corresponds to the TNM classification. It allows us to calculate the different growth periods of PT and MTS: 1) a non-visible period for PT, 2) a non-visible period for MTS, and 3) a visible period for MTS. The CoMPaS has been validated using 10-year and 15-year survival clinical data con- sidering tumor stage and PT diameter. The following are calculated by CoMPaS: 1) the number of doublings for the non-visible and visible growth periods of MTS and 2) the tumor volume doubling time (days) for the non-visible and visible growth periods of MTS. The diameters of the PT and secondary distant MTS increased simultaneously. In other words, the non-visible growth period of the secondary distant MTS shrinks, leading to a decrease of the survival of patients with breast cancer. The CoMPaS correctly describes the growth of the PT for patients at the T1aN0M0, T1bN0M0, T1cN0M0, T2N0M0 and T3N0M0 stages, who does not have MTS in the lymph nodes (N0). Additionally, the CoMPaS helps to con- sider the appearance and evolution period of secondary distant MTS (M1). The CoMPaS correctly describes the growth period of PT corresponding to BC classification (parameter T), the growth period of secondary distant MTS and the 10-15-year survival of BC patients considering the BC stage (parameter M).
Priority areas:
mathematics
Language:
English
Gorbounov Vassily, Kazakov A., Data Analytics and Topology 2025 Vol. 1 No. 1 P. 33–45
A classic problem in data analysis is studying the systems of subsets defined by either a similarity or a dissimilarity function on X which is either observed directly or derived from a data set.
For an electrical network there are two functions on the set of the nodes defined by the resistance matrix and the response ...
Added: May 28, 2026
Mokienko O., Zisman M. A., Bobrov Pavel et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Degtyarev A., Bakhurin S., Yudin N., DSPA 2026 P. 1–6
This paper investigates one possible solution to the problem of self-interference cancellation (SIC) arising in the design of in-band full-duplex (IBFD) communication systems. Self-interference cancellation is performed in the digital domain using multilayer nonlinear models adapted via gradient-based optimization. The presence of local minima and saddle points during the adaptation of multilayer models limits the ...
Added: May 26, 2026
Ilyashenko Y., Shilin I., Stanislav Minkov, Russian Journal of Mathematical Physics 2026 Vol. 33 No. 1 P. 89–106
In this paper, new numerical invariants of structurally unstable vector fields in the plane
are found. One of the main tools is an improved asymptotics of sparkling saddle connections that
occur when a separatrix loop of a hyperbolic saddle breaks. Another main tool is a new topological
invariant of two arithmetic progressions, both perturbed and unperturbed, on the ...
Added: May 26, 2026
Gusev I., Maksaev A., Promyslov V., Journal of Mathematical Sciences 2025 Vol. 299 No. 6
The regular graph of the space of n × m matrices over a field F is defined as the undirected graph whose vertices are matrices of rank min(n, m), and distinct matrices A and B are connected by an edge if and only if rk(A + B) < min(n, m). In this paper, for |F| ...
Added: May 25, 2026
Tyukin I., Tyukina T., van Helden D. P. et al., Information Sciences 2024 Vol. 678 Article 120856
AI errors pose a significant challenge, hindering real-world applications. This work introduces a novel approach to cope with AI errors using weakly supervised error correctors that guarantee a specific level of error reduction. Our correctors have low computational cost and can be used to decide whether to abstain from making an unsafe classification. We provide ...
Added: May 23, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
Chertopolokhov V., Mukhamedov A., Bugriy G. et al., IEEE Access 2026 Vol. 14 P. 14369–14392
This study presents on-the-fly identification and multi-step prediction of nonlinear systems with delayed inputs using a dynamic neural network combined with a smooth projection onto ellipsoids. The projection enforces parameter constraints that guarantee stability, while a Lyapunov–Krasovskii analysis yields computable ultimate error bounds. Riccati-type matrix inequalities are derived, providing an efficient vectorization–projection–devectorization implementation suitable for ...
Added: May 22, 2026
Морозов С. В., Calcolo 2026 Vol. 63 No. 2 Article 23
The approximation of tensors in a low-para metric format is a crucial component in many mathematical modelling and data analysis tasks. Among the widely used low-parametric representations, the canonical polyadic (CP) decomposition is known to be very efficient. Nowadays, most algorithms for CP approximation aim to construct the approximation in the Frobenius norm; however, some ...
Added: May 22, 2026
Селянин Ф. И., Journal of Dynamical and Control Systems 2026 Vol. 32 No. 2 Article 18
A B-facet is a lattice -dimensional polytope in the positive octant with a positive normal covector, such that every -dimensional simplex with vertices in it is a B-simplex (i.e., a pyramid of height one with base on a coordinate hyperplane). B-facets were introduced in [2] in the context of the monodromy conjecture. In this paper, we complete the ...
Added: May 21, 2026
Ausubel L., Baranov O., Journal of Economic Theory 2026 Vol. 235 Article 106192
The Vickrey-Clarke-Groves (VCG) mechanism is one of the most compelling constructs in mechanism design, but the presence of complementary goods creates the possibility of non-core and even zero-revenue outcomes. In this article, we show that joint feasibility constraints on allocations offer a second pathway to ill-behaved outcomes in the VCG mechanism, even when all bidders ...
Added: May 20, 2026
Denis Seliutskii, Russian Journal of Mathematical Physics 2025 Vol. 32 No. 2 P. 399–407
In this paper, we find an upper bound for the first Steklov eigenvalue for a surface of revolution with boundary consisting of two spheres of different radii. Moreover, we prove that, in some cases, this boundary is sharp. ...
Added: May 19, 2026
Жакупов О. Б., European Journal of Mathematics 2025 Vol. 11 Article 84
We provide examples of smooth three-dimensional Fano complete intersections of degree 2, 4, 6, and 8 that have absolute coregularity 0. Considering the main theorem of Avilov, Loginov, and Przyjalkowski (CNTP 18:506–577, 2024) on the remaining 101 families of smooth Fano threefolds, our result implies that each family of smooth Fano threefolds has an element of absolute ...
Added: May 18, 2026
Gurevich E., Saraev I., Известия РАН. Серия математическая 2026 Т. 90 № 3 С. 19–56
In this paper, we consider a class of gradient-like ows without heteroclinic
intersections, dened on closed manifolds of dimension four. We show that for
such ows, the problem of complete topological classication can be reduced to
the combinatorial problem of distinguishing special framed graphs describing
the mutual arrangement of invariant manifolds and the action of the ow on a
wandering ...
Added: May 18, 2026
Gonchenko S., Lerman L., Turaev D., Regular and Chaotic Dynamics 2026 Vol. 31 No. 3 P. 349–369
We show that bifurcations of four-dimensional symplectic diffeomorphisms with a quadratic homoclinic tangency to a saddle periodic orbit with real multipliers produce 2-elliptic periodic orbits if the tangency is not partially hyperbolic. We show that a normal form for the rescaled first-return maps near such tangency is given by a four-dimensional symplectic H´enonlike map and study bifurcations of the ...
Added: May 15, 2026
Aleskerov F. T., Khutorskaya O., Stepochkina A. et al., Springer, 2026.
The book contains new models of bibliometric analysis based on centrality measures in network analysis, pattern analysis and stability analysis. A distinctive feature of these centrality measures is that they account for the parameters of vertices and group influence of vertices to a vertex. This reveals specific groups of publications, authors, terms, journals and affiliations ...
Added: May 15, 2026
Kuptsov P., Panyushev A., Stankevich N., Chaos 2026 Vol. 36 No. 5 Article 053138
We develop a machine-learning approach to reproduce the behavior of two versions of the van der Pol oscillator exhibiting a subcritical Andronov–Hopf bifurcation, with or without a codimension-2 Bautin point. We construct a neural-network model that functions as a recur rent map and train it on short segments of oscillator trajectories. The results show that, ...
Added: May 15, 2026
Dorovskiy A., / Series arXiv "math". 2026.
In this paper the structural stability of generic families of vector fields of the PC-HC class on the two-dimensional sphere is proved. A classification of these families up to moderate equivalence in neighborhoods of their large bifurcation supports is presented, based on such invariants as the configuration and the characteristic set. The realization lemma is proved. ...
Added: May 14, 2026
Lebedev V., Journal of Mathematical Analysis and Applications 2026 Vol. 563 No. 2 Article 130787
It is known that for every continuous real-valued
function $f$ on the circle $\mathbb T=\mathbb R/2\pi\mathbb Z$ there exists a
change of variable, i.e., a self-homeomorphism $h$ of $\mathbb T$, such that
the superposition $f\circ h$ is in the Sobolev space $W_2^{1/2}(\mathbb T)$.
We obtain new results on simultaneous improvement of functions by a single
change of variable in relation ...
Added: May 14, 2026
Taletskii D., / Series arXiv "math". 2026.
A vertex subset of a graph is called a \textit{distance-$k$ independent set} if the distance between any two of its distinct vertices is at least $k + 1$. For all $n,k \geq 1$, we determine the minimum possible number of inclusion-wise maximal distance-$k$ independent sets among all $n$-vertex trees. It equals~$n$ if $n \leq k ...
Added: May 1, 2026
Vinokurov Y., Kofanov Y. N., Sotnikova S., В кн.: Инновационные, информационные и коммуникационные технологии: сборник трудов XXII Международной научно-практической конференции. Москва, 2025.: Ассоциация выпускников и сотрудников ВВИА им. проф. Жуковского, 2025. С. 129–134.
В статье представлены результаты разработки и валидации комплексной математической модели в виде ненаправленного графа для конкретного применения, а именно для проведения виртуальных тепловых испытаний электронной аппаратуры. Предложена структура модели, включающая четыре подмодели: тепловых процессов внутри аппаратуры, взаимодействия с испытательным оборудованием, внешнего температурного воздействия, взаимодействия с оснасткой и с измерительной системой. Описаны методы получения исходных данных ...
Added: May 1, 2026
Ovcharenko M., / Series arXiv "math". 2026.
We introduce an explicit class of tempered Laurent polynomials in the sense of Villegas and Doran--Kerr in n⩽4 variables including all Landau--Ginzburg models for smooth Fano threefolds with very ample anticanonical class. We check that it contains Landau--Ginzburg models for various Fano fourfolds which are complete intersections in smooth toric varieties and Grassmannians of planes, ...
Added: April 30, 2026
Бодунова Н. А., Хатьков И. Е., Найговзина Н. Б. et al., Вестник Всероссийского общества специалистов по медико-социальной экспертизе, реабилитации и реабилитационной индустрии 2026 Т. 22 № 1 С. 109–122
Introduction. The increasing incidence and mortality of cancer, along with the growing contribution of hereditary malignancies, necessitate the implementation of personalized prevention models based on molecular genetic risk stratification and early cancer detection among asymptomatic carriers of highly penetrant germline mutations. Aim. The aim of this study was to evaluate the clinical and economic effectiveness ...
Added: April 22, 2026
Zlotnik Alexander, / Series arXiv "math". 2026. No. 2602.03481v1.
We deal with the global in time weak solutions to the 1D compressible Navier-Stokes system of equations for large discontinuous initial data and nonhomogeneous boundary conditions of three standard types. We prove the Lipschitz-type continuous dependence of the solution $(\eta,u,\theta)$, in a norm slightly stronger than $L^{2,\infty}(Q)\times L^2(Q)\times L^2(Q)$, on the initial data $(\eta^0,u^0,e^0)$ in a ...
Added: April 18, 2026