Article
Географические особенности Волговерховья как объекта наследия и туризма
Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.
The article is devoted to the history of the Russian Research Institute Cultural and Natural Heritage named after D. S. Likhachev, formation of structure, fields of research and main results of the activities of the Heritage Institute for 1992-2013.
We have compiled a detailed list of publications of the Heritage Institute books and its employees for the period from 1992 to 2013
The paper aims to discuss the multifaceted links between the marine environment of the Gulf of Finland and the representations of the large complex of cultural heritage related to the city of St. Petersburg. The paper is based on a spatial imaginary of Greater St. Petersburg as the cultural and technological unity of the city and adjacent waterscapes in the times of the Russian Empire. This concept is instrumental to see the historical links between the parts of the heritage complex that has by now disintegrated and has been separated by state borders.
The section provides the uniqueness of the landscape and assessment of the natural heritage of the territory of the Bolgar historical and archaeological complex. Described environmentally valuable natural features, reveals the dangerous and adverse effects of natural processes on the territory of Bolgar historical and archaeological complex. Described the landscape zoning of the buffer zone and types of dangerous and unfavorable natural processes in its territory, and associated restrictions when used in a cultural, tourist and other purposes.
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells. Oxyquinoline derivative inhibits HIF-prolyl hydroxylase by stabilizing HIF-1 transcription complex, thus modeling cell response to hypoxia. In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene. These changes in the expression profile attest to activation of the metabolic cell reprogramming mechanisms aimed at reducing oxygen consumption by enabling the switch from aerobic to anaerobic glucose metabolism and the respective decrease in number of mitochondria. The possibility of practical use of the therapeutic properties of oxyquinoline derivatives is discussed.