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Plasticity of central and peripheral sources of noradrenaline in rats during ontogenesis
Biochemistry. Biokhimiia. 2017. Vol. 82. No. 3. P. 373–379.
Bondarenko N. S., Dilmukhametova L. K., Kurina A. Y., Murtazina A. R., Sapronova A. Y., Sysoeva A. P., Ugrumov M.
The morphogenesis of individual organs and the whole organism occurs under the control of intercellular chemical signals mainly during the perinatal period of ontogenesis in rodents. In this study, we tested our hypothesis that the biologically active concentration of noradrenaline (NA) in blood in perinatal ontogenesis of rats is maintained due to humoral interaction between its central and peripheral sources based on their plasticity. As one of the mechanisms of plasticity, we examined changes in the secretory activity (spontaneous and stimulated release of NA) of NA-producing organs under deficiency of its synthesis in the brain. The destruction of NA-ergic neurons was provoked by administration of a hybrid molecular complex–antibodies against dopamine-β-hydroxylase associated with the cytotoxin saporin–into the lateral cerebral ventricles of neonatal rats. We found that 72 h after the inhibition of NA synthesis in the brain, its spontaneous release from hypothalamus increased, which was most likely due to a compensatory increase of NA secretion from surviving neurons and can be considered as one of the mechanisms of neuroplasticity aimed at the maintenance of its physiological concentration in peripheral blood. Noradrenaline secretion from peripheral sources (adrenal glands and the organ of Zuckerkandl) also showed a compensatory increase in this model. Thus, during the critical period of morphogenesis, the brain is integrated into the system of NA-producing organs and participates in their reciprocal humoral regulation as manifested in compensatory enhancement of NA secretion in each of the studied sources of NA under specific inhibition of NA production in the brain.
Petrova D., Biomolecules 2025
Added: January 18, 2026
Mcvey A. V., Коммуникации. Медиа. Дизайн 2025 Т. 10 № 1 С. 74–112
В статье многосторонне исследуется понятие «нейроарт». Проведен анализ существующих в художественном и медиадискурсах трактовок данного понятия, выявлена двойственная практика его употребления в отношении двух различных направлений современного искусства: 1) художественных практик, связанных с использованием искусственных нейронных сетей, 2) художественных практик, использующих нейротехнологии в качестве выразительных средств. Каждое из направлений проанализировано с учетом своей медиальной специфичности. ...
Added: May 5, 2025
Филиппова М. Г., Sherbakova O., Shtyrov Y., Neuroscience and Behavioral Physiology 2020 Vol. 50 No. 3 P. 306–314
Perceptual information is often ambiguous and we have to deal with such ambiguity to ensure optimal behavior; yet, the mechanisms that our brain uses for processing ambiguous stimuli are not well understood. In the current study, we tested whether there were any common markers of neural processing of ambiguity, regardless of its type. To this ...
Added: April 2, 2025
Sherbakova O., Myachykov A., Martín-Luengo B. et al., Frontiers in Human Neuroscience 2020 Vol. 14 No. n/a Article 324
Language is a uniquely human cognitive function, which greatly defines and determines our psychological and social traits. Despite the importance of language and speech, they remain among the least understood human cognitive processes, and their neurobiological underpinnings are still poorly understood.
In recent decades, an immense body of diverse data illuminating the neural bases of language ...
Added: March 31, 2025
Перикова Е. И., Блинова Е. Н., Андрющенко Е. А. et al., Физиология человека 2023 Т. 49 № 3 С. 96–105
The primary motor cortex takes part in various stages of language learning accompanied by human motor activity. However, previous studies of causal relationships between the activation of primary motor cortex and efficiency of language tasks reveal contradictory results, likely due to diverging learning environments and specific movement patterns required by different experimental designs. The goal ...
Added: March 3, 2025
Бехтерев В. М., М.: АСТ: Кладезь, 2023.
V. M. Bekhterev's (1857-1927) contribution to science is invaluable: he was the founder of reflexology and patapsychology, and was an outstanding psychiatrist. “Phenomena of the Brain” is a collection on hypnosis, suggestion and telepathy, which will reveal their influence on both human consciousness and social life. ...
Added: February 18, 2025
Shtyrov Y., Perikova E., Filippova M. et al., Neurobiology of Learning and Memory 2024 Vol. 216 Article 107992
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that can alter the state of the stimulated brain area and thereby affect neurocognitive processes and resulting behavioural performance. Previous studies using tDCS to address the language function have shown disparate results, particularly with respect to language learning and word acquisition. To fill this gap, ...
Added: December 2, 2024
Zhao A., Ermolaeva A., Ullner E. et al., Physical Review Research 2022 Vol. 4 No. 4 Article 043069
We show that unavoidable stochastic fluctuations are not only affecting information processing in a destructive or constructive way, but may even induce conditions necessary for the artificial intelligence itself. In this proof-of-principle paper we consider a model of a neuron-astrocyte network under the influence of multiplicative noise and show that information encoding (loading, storage, and ...
Added: March 12, 2024
Kolacheva A., Bannikova A., Pavlova E. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 1 Article 683
The fight against neurodegenerative diseases, including Parkinson’s disease (PD), is among the global challenges of the 21st century. The low efficiency of therapy is due to the late diagnosis and treatment of PD, which take place when there is already significant degradation of the nigrostriatal dopaminergic system, a key link in the regulation of motor ...
Added: March 1, 2024
Baulina M., Kosonogov V., Frontiers in Psychology 2024 Vol. 14 Article 1218124
Developmental dyscalculia (DD) is a subtype of learning disabilities, which is characterized by lower mathematical skills despite average intelligence and average or satisfactory performance in other academic areas. It is not fully understood how such deficits emerge in the course of brain development. When considering the mechanisms of dyscalculia, two domain-specific systems are distinguished. The ...
Added: November 13, 2023
Alshanskaia E., Martynova O., IEEE, 2023.
Cognitive and emotional load in the course of increasing the complexity of tasks leads to the activation of various parts of the autonomic nervous system (ANS) and can be accompanied by an increase in the efficiency of problem solving. An increase in cognitive load under the condition of high motivation is a stress factor and ...
Added: September 24, 2023
Shepelenko A., Kosonogov V., Neuroscience and Behavioral Physiology 2023 Vol. 53 No. 2 P. 242–246
Prosocial behavior is a complex process of social interactions whose cerebral support has received insufficient study. Two major groups of factors motivating people to donate their resources for others' benefit have been identified – the altruistic and the egoistic. Regardless of motivation, activation of the ventromedial prefrontal cortex is seen during donation-related decision-taking. In addition, ...
Added: December 17, 2022
Гаджиева Г. И., Kosonogov V., Психиатрия, психотерапия и клиническая психология 2023 Т. 14 № 1 С. 58–69
The review introduces the reader to modern psychophysiological approaches to the study of emotion regulation and briefly outlines the data obtained with the help of such approaches. Among the somatovegetative methods of studying the emotional state in the implementation of regulation, it is worth mentioning facial EMG, SGR, heart rate. These methods allow to quickly ...
Added: October 19, 2022
А. С. Малышевская, Ф. Галло, А. А. Ефремов et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 5 С. 591–608
Development of science, society and medicine leads to a steady increase in average life expectancy. As a result, science is facing new challenges, including prevention of dementia and the maintenance of efficient brain performance during human aging. Bilingualism is one of the protective factors that prevent cognitive decline and maintain brain neuroplasticity. However, the debate ...
Added: October 18, 2022
Shepelenko A., Kosonogov V., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 5 С. 643–650
Prosocial behavior is a complex process of social interaction, the brain support of which has not been fully studied. There are two main groups of factors that encourage people to give their resources for the benefit of others – altruistic and egoistic. Regardless of the motives of donations, the ventral medial prefrontal cortex is activated ...
Added: July 4, 2022
Barisano G., Sepehrband F., Collins H. R. et al., Proceedings of the National Academy of Sciences of the United States of America 2022 Vol. 119 No. 17 Article e2120439119
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurring in the perivascular spaces (PVS) in NASA and ...
Added: April 26, 2022
Doroshin A., Jillings S., Jeurissen B. et al., Frontiers in Neural Circuits 2022 Vol. 16 Article 815838
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long-duration spaceflight based ...
Added: March 20, 2022
Pavlova E. N., Mingazov E. R., Surkov S. A. et al., Doklady Biochemistry and Biophysics 2019 Vol. 489 No. 1 P. 399–402
Nigrostriatal dopaminergic neurons (DNs), involved in the regulation of motor function, are characterized
by a high plasticity. Indeed, at the death of up to 50% of DNs in Parkinson’s disease, the survived
neurons provide normal regulation. This study was aimed to determine whether the vesicle cycle proteins,
syntaxin Ia (Syn Ia), synaptotagmin I (Syt I), Rab5a, and complexins ...
Added: January 12, 2022
Kurtova A. I., Dil’mukhametova L. K., Pronina T. S. et al., Russian Journal of Developmental Biology 2020 Vol. 51 No. 1 P. 57–64
Dopamine (DA), which is synthesized in DA-ergic neurons and so-called monoenzymatic neurons,
is involved in the regulation of neuronal differentiation during the critical period of morphogenesis. The
aim of the present study was to examine phenotypic features of DA-producing neurons in several brain
regions, including the striatum, suprachiasmatic nucleus, and arcuate nucleus, during rat ontogeny starting
from embryonic day ...
Added: January 12, 2022
Herrojo-Ruiz M. D., Maudrich T., Kalloch B. et al., Scientific Reports 2021 Vol. 11 No. 1 Article 20303
The frontopolar cortex (FPC) contributes to tracking the reward of alternative choices during decision making, as well as their reliability. Whether this FPC function extends to reward gradients associated with continuous movements during motor learning remains unknown. We used anodal transcranial direct current stimulation (tDCS) over the right FPC to investigate its role in reward-based ...
Added: December 14, 2021
Alexandrov Y., Svarnik O., Znamenskaya I. et al., Journal of Analytical Psychology 2020 Vol. 65 No. 3 P. 476–496
As shown in our previous paper (‘Regression I. Experimental approaches to
regression’, JAP, 65, 2, 345-65), the common mechanism of regression can be
described as reversible dedifferentiation, which is understood as a relative increase of
the proportion of low-differentiated (older) systems in actualized experience.
Experimental data show that regression following disease (chronic tension headache) is
followed by adaptation and an ...
Added: December 28, 2020
Alexandrov Y., Feldman B., Svarnik O. et al., Journal of Analytical Psychology 2020 Vol. 65 No. 2 P. 345–365
The concept of regression is considered with an emphasis on the differences
between the positions of Freud and Jung regarding its significance. The paper discusses
the results of experimental analyses of individual experience dynamics (from gene
expression changes and impulse neuronal activity in animals to prosocial behaviour in
healthy humans at different ages, and humans in chronic pain) in ...
Added: December 28, 2020