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Экспрессия генов пероксиредоксинов 1, 2, 3 и 6 при формировании лекарственной устойчивости опухолевых клеток
БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ, Россия. 2012. Т. 153. № 6. С. 861-864.
Калинина Е. В., Березов Т. Т., Штиль А. А., Чернов Н. Н., Глазунова В.А., Новичкова Н. Д., Нумурадов Н. К.
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2012 Т. 10 № 8 С. 27-33
Исследованы характер экспрессии генов Prx 1, 2 и 6 при формировании лекарственной устойчивости опухолевых клеток к доксорубицину (DOX), цитотоксический эффект которого помимо интеркалирующего действия связан с активацией образования активных форм кислорода. Полученные данные свидетельствуют в пользу важной роли редокс-зависимого механизма формирования устойчивости опухолевых клеток к DOX. ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2012 Т. 10 № 5 С. 51-57
Проведена оценка экспрессии генов изоформ тиоредоксина и тиоредоксинредуктазы при формировании лекарственной устойчивости опухолевых клеток к доксорубицину. Показано, что у резистентных к DOX опухолевых клеток K562/DOX, MCF-7/DOX, SKVLB обнаружен рост экспрессии генов TRX2 и TRXRD1, тогда как повышение экспрессии гена TRX1 установлено только в клетках SKVLB. Во всех трех типах резистентных клеток обнаружен рост активности как ...
Added: July 14, 2015
Shchekotikhin A. E., Glazunova V.A., Dezhenkova L. G. et al., Bioorganic and Medicinal Chemistry 2009 Vol. 17 No. 5 P. 1861-1869
We developed the synthesis of a series of thiophene-fused tetracyclic analogues of the antitumor drug ametantrone. The reactions included nucleophilic substitution of methoxy groups in 4,11-dimethoxyanthra[2,3-b]thiophene-5,10-diones with ethylenediamines, producing the derivatives of 4,11-diaminoanthra[2,3-b]thiophene-5,10-dione in good yields. Several compounds showed marked antiproliferative potency against doxorubicin-selected, P-glycoprotein-expressing tumor cells and p53-/- cells. The cytotoxicity of some novel compounds ...
Added: July 14, 2015
Shchekotikhin A. E., Glazunova V.A., Dezhenkova L. G. et al., European Journal of Medicinal Chemistry, France 2011 Vol. 46 No. 1 P. 423-428
We developed the synthesis of a series of furan-fused tetracyclic analogues of the antitumor agent ametantrone. The reactions included nucleophilic substitution of propoxy groups in 4,11-dipropoxyanthra[2,3-b]furan-5,10-diones with ethylenediamines, producing the derivatives of 4,11-diaminoanthra[2,3-b] furan-5,10-dione in good yields. Studies of anti-proliferative activity on a panel of mammalian tumor cell lines demonstrated that anthra[2,3-b]furan-5,10- diones were the ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2011 Т. 9 № 10 С. 35-41
Проведена оценка экспрессии генов, контролирующих синтез GSH, при формировании лекарственной устойчивости опухолевых клеток к доксорубицину (DOX). У резистентных к DOX опухолевых клеток K562/DOX, MCF-7/DOX, SKVLB обнаружен скоординированный рост экспрессии генов тяжелой и легкой субъединиц γ-глутамилцистеинсинтетазы, глутатионсинтетазы и γ-глутамилтрансферазы, который можно расценивать как результат развития оптимальных условий для повышения синтеза GSH de novo, что наряду с ростом ...
Added: July 14, 2015
Kobayashi Y., Kulikova Sofya P, Shibato J. et al., World Journal of Biological Chemistry 2015 Vol. 6 No. 4 P. 389-408
N-Methyl-D-aspartate receptors (NMDAr) are involved in multiple physiological functions and neuropsychiatric disorders. Dizocilpine (commonly referred to as MK-801) is a well-known non-competitive NMDAr antagonist with psychotomimetic properties. A combination of electrophysiological and molecular analyses reveals not only the synchrony of baseline oscillations by MK-801, but also more importantly new insight into differential gene expressions in ...
Added: October 22, 2015
Глазунова В.А., Лобанов К. В., Шакулов Р. С. et al., Acta Naturae 2013 Т. 5 № 3 С. 78-82
We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter P-glycoprotein or lack of ...
Added: July 14, 2015
Lavrenov S. N., Luzikov Y. N., Bykov E. E. et al., Bioorganic and Medicinal Chemistry 2010 Vol. 18 No. 18 P. 6905-6913
Novel derivatives of tris(indol-3-yl)methane and tris(indol-3-yl)methylium salts with the alkyl substituents at the N-atoms of the indole rings were synthesized. An easy substitution of indole rings in trisindolylmethanes for other indoles under the action of acids is demonstrated, and the mechanism of substitution is discussed. To obtain trisindolylmethylium salts, the environmentally safe method of oxidation ...
Added: July 14, 2015
Shchekotikhin A. E., Glazunova V.A., Dezhenkova L. G. et al., European Journal of Medicinal Chemistry, Elsevier, France 2014 Vol. 86 P. 797-805
A series of new 3-aminomethyl-411-dihydroxynaphtho[2,3-f]indole-5,10-diones 6-13 bearing the cyclic diamine in the position 3 of the indole ring was synthesized. The majority of new compounds demonstrated a superior cytotoxicity than doxorubicin against a panel of mammalian tumor cells with determinants of altered drug response, that is, Pgp expression or p53 inactivation. For naphtho[2,3-f]indole-5,10-diones 6-9 bearing ...
Added: July 14, 2015
Dmitrieva E., Talibov A. K., Фадейкин М. А., Ученые записки университета им. П.Ф. Лесгафта 2015 № № 3(121) С. 142-146
http://lesgaft-notes.spb.ru ...
Added: February 12, 2016
Vlassov V., Neuro-epidemiology 2015 Vol. 45 No. 3 P. 177-189
Background: There is increasing recognition of stroke as an important contributor to childhood morbidity and mortality. Current estimates of global childhood stroke burden and its temporal trends are sparse. Accurate and up-to-date estimates of childhood stroke burden are important for planning research and the resulting evidence-based strategies for stroke prevention and management. Objectives: To estimate ...
Added: October 29, 2015
Стара Загора : Издателски консорциум "КОТА", 2016
Юбилейна научна конференция за преподаватели, студенти и специалисти по здравни гриди с международно участие "10 години специалност "Медицинский лаборант" в Медицнски-колеж - Стара Загора" ...
Added: April 15, 2017
Nicol R., Chapman S., Vertes P. et al., Journal of Neurophysiology (США) 2012 Vol. 107 No. 5 P. 1421-1430
How do human brain networks react to dynamic changes in the sensory environment? We measured rapid changes in brain network organization in response to brief, discrete, salient auditory stimuli. We estimated network topology and distance parameters in the immediate central response period, <1 s following auditory presentation of standard tones interspersed with occasional deviant tones ...
Added: October 23, 2014
Moseley R., Shtyrov Yury, Mohr B. et al., Neuroimage 2015 Vol. 104 P. 413-422
Autism spectrum conditions (ASC) are characterised by deficits in understanding and expressing emotions and are frequently accompanied by alexithymia, a difficulty in understanding and expressing emotion words. Words are differentially represented in the brain according to their semantic category and these difficulties in ASC predict reduced activation to emotion-related words in limbic structures crucial for ...
Added: October 23, 2014
Vlassov V.V., The Lancet 2016 Vol. 388 No. 10049 P. 1081-1088
Background
With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral ...
Added: July 9, 2016
Shtyrov Y., Smith M., Horner A. et al., Neuropsychologia 2012 Vol. 50 No. 11 P. 2605-2616
Previous research indicates that, under explicit instructions to listen to spoken stimuli or in speech-oriented behavioural tasks, the brain's responses to senseless pseudowords are larger than those to meaningful words; the reverse is true in non-attended conditions. These differential responses could be used as a tool to trace linguistic processes in the brain and their ...
Added: October 23, 2014
Vlassov V., The Lancet 2016 Vol. 388 No. 10053 P. 1545-1602
Background
Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 ...
Added: October 13, 2016
Vlassov V., The Lancet 2016 Vol. 388 No. 10053 P. 1725-1774
Background
Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in ...
Added: October 13, 2016
Shchekotikhin A. E., Luzikov Y. N., Buyanov V. N. et al., Bioorganic and Medicinal Chemistry 2006 Vol. 14 No. 15 P. 5241-5251
We describe the synthesis of derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione and their cytotoxicity for human tumor cells that express major determinants of altered anticancer drug response, the efflux pump P-glycoprotein, and non-functional p53. Nucleophilic substitution of methoxy groups in 4,11-dimethoxynaphtho[2,3-f]indole-5,10-dione with various ethylenediamines yielded the derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione, the indole containing analogues of the antitumor agent ametantrone. ...
Added: July 9, 2015
Moseley R., Pulvermuller F., Mohr B. et al., Journal of Autism & Developmental Disorders 2014 Vol. 44 No. 1 P. 137-153
Reading utilises at least two neural pathways. The temporal lexical route visually maps whole words to their lexical entries, whilst the nonlexical route decodes words phonologically via parietal cortex. Readers typically employ the lexical route for familiar words, but poor comprehension plus precocity at mechanically 'sounding out' words suggests that differences might exist in autism. ...
Added: October 23, 2014
Vlassov V., The Lancet 2014 Vol. 348 No. 9947 P. 1005-1070
Abstract: Background
The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis and malaria through the formulation of Millennium Development Goal 6 (MDG 6). The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation 1990 to 2013, and an opportunity to assess if there has been accelerated progress since the Millennium ...
Added: May 30, 2014
Буторина А., Shestakova A., Николаева А. et al., Современная зарубежная психология 2012 Т. 1 С. 103-113
На сегодняшний день в клинической практике и научных исследованиях остро стоит проблема локализации речевых зон человека. Несмотря на то, что два важнейших центра речи человека были выявлены достаточно давно (зоны Брока и Вернике, отвечающая за порождение и понимание речи соответсвенно), их расположение и даже полушарная латерализация могут сильно варьировать, создавая необходимость в надежной методике картирования ...
Added: October 23, 2014
Сургут : Сургутский государственный университет, Копи-Центр, 2004
Главная цель Конгресса – поддержка регионообразующих процессов в зоне мирового Севера, создание единой информационной базы, отражающей современный опыт развития северных территорий, развитие межрегионального и международного сотрудничества.
Основные направления работы Конгресса: Северные регионы в системах геополитического и геоэкономического баланса Модели управления северными территориями: стратегии социального партнерства Современное предпринимательство в условиях Мирового Севера: экономические и социокультурные аспекты Гуманитарные ресурсы Севера - ...
Added: August 19, 2014