Мета-аналитический подход в изучении антигипертензивной эффективности индапамида с контролируемым высвобождением в терапии больных с артериальной гипертензией (по данным открытых исследований)
Abstract The paper presents a meta-analysis of open-label antihypertensive effectiveness studies of indapamide SR (Arifon Retard, Servier Laboratories, France) in hypertensives. 24 Russian (n = 4952) and 4 foreign (n = 4634) studies were included in analysis. Russian studies show that indapamide retard both as a monotherapy and a component of the combination therapy leads to a 17,8/14,0 % decrease of systolic/diastolic blood pressure that is a reduction for 29.2 (95 % CI 28,9–29,5)/12,3 (12,1–12,5) mmHg in patients with uncontrolled hypertension. Baseline blood pressure was the main predictor of its reduction, and the most signifi cant reduction for 32,6 (95 % CI 25,5–39,6) mmHg was seen when the average baseline systolic blood pressure exceeded 170 mmHg. Antihypertensive effi cacy of indapamide retard was similar in Russian and foreign studies. However, incidence of therapy-related side effects was higher in Russian studies than in foreign ones (5,9 and 3,3 % respectively, p < 0,001). Therefore, meta-analysis based on the data of open Russian studies confi rms the antihypertensive effectiveness of indapamide retard and demonstrates the comparability of the results to those found in multicenter foreign studies.
In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine
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Study of seasonal and psychological determinants of blood pressure.
The concept and aim of evidence-based entrepreneurship (EBE) is discussed as a strategy to overcome the divide between knowledge developed in the field of entrepreneurship and its use in practice. We argue that meta-analyses can and should be used in entrepreneurship research (and that it should also be used for qualitative work).
The emergence on the Russian market of new forms of sales and services, like online-shopping, has formed a new sphere of communication - client/customer service to the actual and potential clients/customers by email. This area is actively developing in Russia for the last 10 years. On the basis of the analysis of the examples of e-mails, sent to the real people by the customer services of 115 different companies, the author formulates the main trends of the use of forms of address in this sphere.
The paper uses meta-analysis to investigate the evolution of returns to education in Russia during the economic transition. We present the evidence of strong increase in returns to education in the 1990s. The returns to education peaked at 8% per additional year of schooling in the early 2000s. Since the mid-2000s the positive trend has been reversed. We find that the estimated returns are sensitive to sample design, specification and estimation methods. On average the estimated returns are higher if one uses imputed (instead of actual) years of education and estimates earnings equation with the OLS. Among covariates, the form of ownership and settlement type (urban/ rural) has the largest effect on the estimated returns to education. Regional variables have significant impact on the estimated returns only being included into the earnings equation at the oblast (province) level.
Data management and analysis is one of the fastest growing and most challenging areas of research and development in both academia and industry. Numerous types of applications and services have been studied and re-examined in this field resulting in this edited volume which includes chapters on effective approaches for dealing with the inherent complexity within data management and analysis. This edited volume contains practical case studies, and will appeal to students, researchers and professionals working in data management and analysis in the business, education, healthcare, and bioinformatics areas.
This prototype development explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISO/IEEE 11073 messages and to process them easily. MD act as X73 agent. Second one is focused on more powerful device X73 manager, which do not have the MDs' memory and processor usage constraints. The protocol between Agent and Manager is point-to-point and we can distribute the functionality between devices.
Developed both implementation X73 Agent and Manager will cut developing time for applications based on ISO/EEE 11073.