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СВЯЗЬ ВОСПАЛЕНИЯ И ГЕМОСТАЗА У ПАЦИЕНТОВ С ШИЗОТИПИЧЕСКИМ РАССТРОЙСТВОМ
ACTA BIOMEDICA SCIENTIFICA. 2025. Т. 10. № 4. С. 182–191.
Background. A current research on mental disorders ethiopathology is about to attract a special attention towards a possible role of inflammation/neuroinflammation related metabolic pathways. It has been shown that there is a close link between immunoinflammation and hemostasis. It might be assumed that the interrelated processes of inflammation and blood coagulation are the important elements in pathogenesis of psychiatric diseases. However; this problem remains rather obscure so far.The aim. Identification of significant parameters characterizing the hemostasis system and markers of systemic inflammation; as well as an assessment of their possible relationship in patients with schizotypal disorder.Materials and Methods. Eighteen female patients; aged 16-41 (median age [Q1;Q2] - 20 years [17.0; 26.0]); were hospitalized to the Mental Health Research Center (MHRC) clinic; all in clinically acute conditions. The blood plasma analysis based on evaluation of immune status was performed according to a special «Neuroimmunotest» technology developed and proposed earlier by the above mentioned research center (MHRC). A «Fibrinodynamics» technique was employed to elucidate the hemostasis system functioning in vivo simulating; method is also a product of our research team.Results. It has been shown that the inborn immunity patters (leucocyte elastase catalytic activity and its specific inhibitor - which is an acute phase alfa-1 protein - functional activity) are significantly increased in patients studied. Indicators of acquired immunity (S100B and the basic myelin protein antibodies level values); do not differ from the reference values. A number of «Fibrinodynamics» detected parameters were found of being significantly higher as compared to the referent values. Thus; the values of potentials of coagulation; fibrinolysis and hemostasis are essentially increased; while the hemostasis system equilibrity patterns are the same in patients as in controls. A correlation analysis results are in a favor to the existence of a link between inflammation and hemostasis parameters.Conclusion. The results of a present study reflect an interdependence between immu- noinflammatory and hemostatic systems in schizotypal disorder.
Keywords: шизофрения
Кияненко И. К., Клиническая и специальная психология 2026 Т. 15 № 1 С. 7–19
Context and relevance. The problem of the impact of urban stress factors on mental health is becoming increasingly relevant in the context of urbanization. Living in cities is accompanied by increased psychophysiological stress, which leads to an increase in the prevalence of mental disorders among urban residents. Objective. The purpose of the article is to ...
Added: May 19, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
Изнак Е. В., Дамянович Е. В., Береснева А. Ф. et al., Психиатрия 2024 Т. 22 № 6 С. 27–33
Background: the need to study and clarify the neurobiological basis of depression is due to the widespread prevalence and heavy socioeconomic burden of this disease. In order to prevent relapses, it is recommended to continue treatment for depression for a long time after the relief of the main depressive symptoms. The study of neurobiological pathways ...
Added: March 20, 2026
Изнак А. Ф., Изнак Е. В., Дамянович Е. В. et al., Журнал неврологии и психиатрии им. С.С. Корсакова 2024 Т. 124 № 9 С. 100–103
Objective. To search for neurophysiological correlates of the characteristics of the brain functional state in patients with endogenous depression with an ultra-high risk of developing psychosis in comparison with EEG parameters of patients without symptoms of a risk of developing psychosis and patients who have suffered psychotic episode. Material and methods. The study included 92 ...
Added: March 20, 2026
Mokienko O., Вестник Российской академии медицинских наук 2024 Т. 79 № 5 С. 424–431
A brain-computer interface (BCI) is a system that measures brain activity and converts it in real-time into functionally useful outputs to replace, restore, enhance, supplement, and/or improve the natural outputs of the brain. In invasive BCIs, electrodes are placed intracranially for more accurate and faster data exchange between the brain and external devices. The primary ...
Added: March 18, 2026
Mokienko O., Современные технологии в медицине 2024 Т. 16 № 1 С. 78–90
Brain–computer interfaces allow the exchange of data between the brain and an external device, bypassing the muscular system. Clinical studies of invasive brain–computer interface technologies have been conducted for over 20 years. During this time, there has been a continuous improvement of approaches to neuronal signal processing in order to improve the quality of control ...
Added: March 18, 2026
Mokienko O., Современные технологии в медицине 2025 Т. 17 № 2 С. 73–85
The advancement of novel technologies for the rehabilitation of post-stroke patients represents a significant challenge for a range of interdisciplinary fields. Near-infrared spectroscopy (NIRS) is an optical neuroimaging technique based on recording local hemodynamic changes at the cerebral cortex level. The technology is typically employed in post-stroke patients for diagnostic purposes, including the assessment of ...
Added: March 18, 2026
Mokienko O., Бобров П. Д., Соловьева А. А. et al., Вестник Российского государственного медицинского университета 2025 № 5 С. 91–99
Neurophysiological mechanisms underlying the illusion caused by the mirror visual feedback are still poorly understood, despite the clinical use of mirror therapy for phantom pain and post-stroke hemiparesis. The study aimed to determine the mirror illusion neurophysiological correlates by the simultaneous use of electroencephalography (EEG) recording and near-infrared spectroscopy (NIRS). A total of 30 healthy ...
Added: March 18, 2026
Semenov K., Pimenova E., Sokolov V. et al., Journal of Molecular Liquids 2026 Vol. 449 Article 129382
The recalcitrance of tumors to photodynamic therapy (PDT) has been linked to PDT-induced activation of survival pathways in sublethally afflicted cancer cells that modulate cellular responses to oxidative stress and damage. Survival signaling manifests in regions of the tumor where the tumor cells are insufficiently photosensitized or subjected to inadequate fluence rates. The survival signaling ...
Added: March 5, 2026
Tang G., Ahmadi S., Jillings S. et al., Eye 2025 Vol. 39 No. 18 P. 3294–3305
INTRODUCTION: Robust and objective quantification of ophthalmic and retroorbital structures from standard neuroimaging is an accessible but still untapped resource for clinical assessment. Current approaches mostly rely on subjective manual measurements, introducing variability and limiting clinical integration. We developed and validated an automated ocular morphometrics pipeline enabling diagnostic precision through standardised orbital measurements.
METHODS: The presented pipeline consists of: ...
Added: December 28, 2025
Schoenmaekers C., Jillings S., Mortaheb S. et al., NPJ MICROGRAVITY 2025 Vol. 11 Article 71
Long-duration spaceflight affects otolith-mediated ocular counter-roll (OCR) and brain function, but the relationship between these changes is unclear. This study examines whether OCR changes correlate with functional connectivity (FC) changes in the vestibular network in the same cosmonauts after a long-duration (6-month) spaceflight mission. Using a human vestibular atlas, we found that changes in FC ...
Added: December 28, 2025
N. S. Cherkasov, Tomyshev A. S., Lebedeva I. S. et al., Neuroscience and Behavioral Physiology 2025 Vol. 55 No. 9 P. 1681–1687
Objective. To identify the structural features of the brain in elderly patients with amnestic mild cognitive impairment (aMCI) and the correlations of these features with mild behavioral impairment. Materials and methods. Fifty-three patients with aMCI (age 73.0 ± 8.5 years, nine men) and 34 mentally healthy subjects (66.8 ± 9.6 years, four men) were examined. Cognitive status was ...
Added: December 25, 2025
Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12
Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...
Added: December 22, 2025
Kozlov A., Вершубская Г. Г., Горбунова В. В. et al., Вестник Московского университета. Серия 23: Антропология 2025 № 4 С. 5–18
Abstract
Introduction. The accumulation of regional data on the expression of secular trends contributes to a better understanding of this phenomenon. The focus of the present study is on the body height (BH) of the population of Perm, a large industrial, administrative, and cultural center in the Urals.
This work aimed to systematize data on changes in ...
Added: November 18, 2025
Буткова Т. В., Куликова Л. И., Мальсагова К. А. et al., Математическая биология и биоинформатика 2025 Т. 20 № 2 С. 301–309
С 1990 по 2022 годы число людей с диабетом выросло с 200 до 830 миллионов. Большая часть приходится на инсулиннезависимый диабет 2 типа. Болезнь часто приводит к тяжёлым осложнениям: слепоте, почечной недостаточности, инфаркту, инсульту, ампутациям конечностей. По оценкам ВОЗ, в 2021 году от диабета и заболеваний почек умерло более двух миллионов человек. Глобальные расходы на ...
Added: September 28, 2025
Alexey M. Dvoinin, Kopeyko G., Borisova O. et al., Frontiers in Psychiatry 2025 No. 16 Article 1553990
Introduction: As demonstrated in previous research and clinical observations, the personal value system is subject to disintegration as a consequence of schizophrenia. Patients with schizophrenia are sometimes religious and use religious coping mechanisms. A number of studies emphasize the benefits of positive religious coping as a part of clinical treatment for patients with schizophrenia and ...
Added: April 7, 2025