Diagnostic Accuracy of AI for Opportunistic Screening of Abdominal Aortic Aneurysm in CT: A Systematic Review and Narrative Synthesis

Diagnostics. 2022. Vol. 12. No. 12. Article 3197.

Kodenko M., Vasilev Y., Vladzymyrskyy A., Omelyanskaya O., Leonov D., Blokhin I., Novik V., Kulberg N., Samorodov A., Mokienko O., Reshetnikov R.

In this review, we focused on the applicability of artificial intelligence (AI) for opportunistic abdominal aortic aneurysm (AAA) detection in computed tomography (CT). We used the academic search system PubMed as the primary source for the literature search and Google Scholar as a supplementary source of evidence. We searched through 2 February 2022. All studies on automated AAA detection or segmentation in noncontrast abdominal CT were included. For bias assessment, we developed and used an adapted version of the QUADAS-2 checklist. We included eight studies with 355 cases, of which 273 (77%) contained AAA. The highest risk of bias and level of applicability concerns were observed for the "patient selection" domain, due to the 100% pathology rate in the majority (75%) of the studies. The mean sensitivity value was 95% (95% CI 100-87%), the mean specificity value was 96.6% (95% CI 100-75.7%), and the mean accuracy value was 95.2% (95% CI 100-54.5%). Half of the included studies performed diagnostic accuracy estimation, with only one study having data on all diagnostic accuracy metrics. Therefore, we conducted a narrative synthesis. Our findings indicate high study heterogeneity, requiring further research with balanced noncontrast CT datasets and adherence to reporting standards in order to validate the high sensitivity value obtained.

Keywords: QUADAS, computed tomography, artificial intelligence, abdominal aortic aneurysm, opportunistic screening