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The ancestral architecture of the immune system in simplest animals
Frontiers in Immunology. 2025. Vol. 15. Article 1529836.
Daria Y. Romanova, Moroz L.
~520 million years ago, the long biogeochemical history of our planet Earth resulted in a biodiversity burst. The rapid diversification of animals known as the Cambrian explosion (1); transformed planetary ecosystems with novel habitats and food chains (2, 3). However, this emergence of Paleozoic biodiversity (4) is still mysterious due to limited information about basal metazoans and their immune systems.
Четверикова М. М., Потемкин А. Н., Stepanova E., Бюллетень экспериментальной биологии и медицины 2026 Т. 182 № 9 С. 242–247
Gemcitabine, a first-line chemotherapeutic agent for bladder cancer (BC), often loses clinical efficacy due
to the development of drug resistance, the underlying mechanisms of which remain poorly understood. In
this work, a highly gemcitabine-resistant RT112/GR cell line was obtained by long-term selection. The MTT
assay revealed a 9312-fold decrease in gemcitabine sensitivity and moderate resistance to cisplatin (2.60-fold,
p ...
Added: October 26, 2026
Maltseva D., Tonevitsky A., Frontiers in Molecular Biosciences 2026 Vol. 13 P. 1–28
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate at varying levels and exhibit distinct tissue-specific expression patterns, indicating the presence of regulatory ...
Added: October 23, 2026
Vasilyev A., Svirin EP, Dubynin I. et al., Cortex 2025 Vol. 189 P. 76–96
Added: October 22, 2026
Karina V. Klycheva, Mariia O. Silkina, Dmitry M. Hushpulian et al., Biochemistry. Biokhimiia 2026 Vol. 91 P. 1842–1858
Involvement of the transcription factor Bach1 in various scenarios of cellular regulation is reviewed herein. To date, the most extensively studied role of Bach1 is that of a repressor of the antioxidant genetic program initiated by the Nrf2 factor. This program counteracts oxidative stress, which triggers both ferroptosis and the intrinsic apoptotic pathway. Bach1 functions unrelated ...
Added: October 22, 2026
Svirin E., Бердышев Д. А., Шишкин С. Л., Вестник Российского государственного медицинского университета 2026 № 3 С. 42–50
Quasi-movements (QMs), which are movement attempts minimized to the point of movement extinction, evoke EEG patterns similar to those of real movement. QMs can model attempted movement in healthy subjects and are therefore of interest as an alternative to motor imagery (MI) in rehabilitation brain–computer interfaces (BCIs), in which the attempted movement of the paralyzed ...
Added: October 22, 2026
Sitdikova K., Tsoy A., Chaprov K. et al., Journal of Neuropathology and Experimental Neurology 2026 Article nlag078
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alterations remains unclear. We used 6-month-old female APPswe/PS1dE9 mice, a model of early amyloid-dominant pathology, to assess cognition and emotionality across a battery of behavioral tests. Amyloid ...
Added: October 22, 2026
Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice
Kassenova A., Svirin E., Sitdikova K. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 11 Article 4994
Added: October 22, 2026
Cespuglio R., Schmitt-Böhrer A., Deykin A. et al., Metabolites 2026 Vol. 16 No. 2 Article 117
Added: October 22, 2026
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Ekaterina D. Riumina, Alekseeva E., Klink G. V. et al., PNAS, США 2026 Vol. 123 No. 35 Article e2619192123
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Evgeny A. Kanaev, Berezhnaya A., Southeast Asia: Actual Problems of Development 2026 Vol. 2 No. 2(71) P. 175–187
The article examines the significance and the place of the digital tools developed by the Regional Comprehensive Economic Partnership (RCEP) in the priorities of the Socialist Republic of Vietnam (SRV). On tracing the RCEP’s origins, evolution, and interim outcomes obtained to date, the article proceeds with assessing the efficiency of the RCEP’s digital tools to ...
Added: July 30, 2026
Plandin F., Temereva E., Zoological Journal of the Linnean Society 2025 Vol. 205 No. 2 Article zlaf139
Although Brachiopoda represent a relatively small phylum, they exhibit significant morphological diversity. One of the central issues in understanding the evolution of the ancestral brachiopod body plan pertains to the homologies among body compartments across the different brachiopod subphyla: Craniiformea, Linguliformea, and Rhynchonelliformea. In this context, the pedicle stands out as one of the most ...
Added: June 15, 2026
Dybskaya V., Sergeyev V., РИСК: Ресурсы, информация, снабжение, конкуренция 2025 № 2 С. 11–17
The origins and importance of supply chain management (SCM) in the modern economy are analyzed. It is shown that the USP is a continuation and development of the concept of integrated business logistics. The evolution of logistics from the 1960s to the 2000s is presented. The main functionality of the ADC for business organizations is ...
Added: April 28, 2026
Leontiev D., Философские науки 2025 Т. 68 № 1 С. 79–91
The paper examines the issue of the humane in the human being in the context of the dialectic between ideals and reality. Reflecting on discussions about human essence leads to the conclusion of its inherent indeterminacy and the multiplicity of potential capabilities within each individual, which develop throughout life. The distinction between ideal and reality ...
Added: September 11, 2025
Haas B., Lou X., Yeung V. W. et al., Personality and Individual Differences 2025 Vol. 247 Article 113398
An important question in cogntive and evolutionary psychology is how the human mind anticipates the future and copes with stress and risk of disease. The parasite-stress model suggests that many patterns of human behavior and thought are adaptations to varying levels of exposure to parasites and pathogens. A growing body of health psychology research shows ...
Added: August 18, 2025
LePoire D., Leonid Grinin, Korotayev A., , in: Navigating Complexity in Big History. Exploring Periodization Across Cosmic and Biosocial Dimensions.: Springer, 2025. P. 495–525.
This volume, “Navigating Complexity in Big History—Exploring Periodization Across Cosmic and Biosocial Dimensions” explores the aspects and proposals for periodization of Big History. This includes considering cross-cutting aspects of measuring complexity (e.g., energy, information, or a combination), considering different mechanisms of natural selection, developing a set of criteria to base the evaluation of frameworks, and ...
Added: May 12, 2025
LePoire D., Leonid Grinin, Andrey Korotayev, , in: Navigating Complexity in Big History. Exploring Periodization Across Cosmic and Biosocial Dimensions.: Springer, 2025. P. 1–27.
Not so many would argue with identifying complexity as a central concept in Big History and universal evolutionism. It is partly because, perhaps, today, many of us are convinced that not only our world but Universe itself is in a state of major change, and the awareness that we are living in a period of ...
Added: May 12, 2025
Navigating Complexity in Big History. Exploring Periodization Across Cosmic and Biosocial Dimensions
David J. L., L. Grinin, Korotayev A., Springer, 2025.
In the editors’ introduction (Chapter 1), the effort to periodize is placed within the historical context along with considerations from complexity science. Subsequent chapters explore various aspects of periodization and complexity by (a) identifying symmetrical cosmic and biosocial trends, (b) testing rigor and criteria for evaluating periodization, (c) attempting to integrate different approaches through multiple ...
Added: May 12, 2025