FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019

Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019. Оксфорд : Wiley, 2019.

Ответственный редактор: M. Purton

Главы книги

Structural basis of the signal transduction via transmembrane domains of type I receptors in norma and pathology

Bocharov E., Lesovoy D., Pavlov K. и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 06-027 P. 130–130.

The human epidermal growth factor (EGFR/HER) and growth hormone (GHR) receptors serve as excellent models of type I receptors to illustrate how ligand-induced conformational rearrangements and specific dimerization of extracellular domains lead to the allosteric activation of the cytoplasmic domains via single-span transmembrane domain (TMD). We determined the alternative dimeric conformations of the EGFR and ...

Добавлено: 1 ноября 2019 г.

Mode of action and biological activity of sevanol and its analogues on acid-sensing ion channels

Osmakov D., Belozerova O., Koshelev S. и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 15-014 P. 183–183.

Acid-sensing ion channels (ASICs), members of the family of amiloride-sensitive degenerin/epithelial Na + -channels, are expressed in neurons of both the peripheral and central nervous system. Among six currently known isoforms of mammalian ASICs, two, namely ASIC1a and ASIC3 are widespread and have the largest physiological contribution such as synaptic plasticity, learning and memory as well as pain perception and inflammation ...

Добавлено: 1 ноября 2019 г.

Dimerization of transmembrane domain of insulin receptor: structure and possible role in activation

Zamaletdinov M., Кузнецов А. С., Maurice P. и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 27-047 P. 262–262.

Insulin receptor (IR) family is represented by three membrane proteins participating in organism development, growth, and vital activity. Modulation of the functioning of these receptors by external agents looks very perspective from a pharmaceutical point of view. Although IR is well studied, little is known about the role of its transmembrane (TM) domain in receptor ...

Добавлено: 1 ноября 2019 г.

Protein–lipid interactions in glycophorin-like dimerization motifs of transmembrane helices

Кузнецов А. С., Maurice P., Ефремов Р. Г., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 27-068 P. 268–269.

Receptor tyrosine kinases (RTK) are vital players in cell signaling governing growth and proliferation. These integral membrane proteins work only in dimeric states, so the conformation of transmembrane dimer determines the signal transferred into cell. Here, we used modern molecular modeling techniques to study details of protein-protein and protein-lipid interactions in model systems containing monomers ...

Добавлено: 1 ноября 2019 г.

Nisin/lipid II interaction in bacterial membrane: molecular dynamics study

Панина И. С., Чугунов А. О., Dmitry Nolde и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 27-069 P. 269–269.

The worldwide rapid emergence of resistant bacteria put at threat the efficacy of antibiotics, thus the development of novel antibacterial agents is urgently needed. The cell wall precursor lipid II consisting the chemically conservative pyrophosphate group represents a promising pharmaceutical target. Antimicrobial peptides, that target lipid II, i.e. lantibiotic nisin, could be excellent prototypes for ...

Добавлено: 1 ноября 2019 г.

Effects of interfering transmembrane peptides on neuraminidase-1 activity

Albrecht C., Dhaideh Z., Appert-Collin A. и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 31-006 P. 295–296.

Elastin is an essential component of numerous human tissues and plays a critical role in elasticity of skin, lungs and arteries. During vascular aging, the elastin network is degraded generating elastin-derived peptides (EDP). The ERC (Elastin Receptor Complex) is a membrane heterotrimeric receptor composed, amongst others, of a membrane-bound neuraminidase, NEU-1. Binding of EDP to ...

Добавлено: 1 ноября 2019 г.

Conformational variability and intramembrane recognition possibly associated with abnormal cleavage of APP transmembrane domain

Urban A., Bocharov E., Nadezhdin K. и др., , in: FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford: Wiley, 2019. Ch. 31-016 P. 299–299.

Bitopic proteins having only one helical transmembrane (TM) domain are a class of biologically significant membrane proteins, including the type I receptors and amyloid precursor protein (APP), which are involved in regulating the homeostasis of human organism and recognized as substrate by c-secretase. Amyloid Ab-peptides forming plaques in brain during Alzheimer disease (AD) are the ...

Добавлено: 1 ноября 2019 г.

Ключевые слова: биофизика, molecular biology, молекулярная биология, Biochemistry, Biophysics, биохимия