Genotoxic Effect of Dicyclopropanated 5-Vinyl-2-Norbornene

Involvement of the transcription factor Bach1 in various scenarios of cellular regulation is reviewed herein. To date, the most extensively studied role of Bach1 is that of a repressor of the antioxidant genetic program initiated by the Nrf2 factor. This program counteracts oxidative stress, which triggers both ferroptosis and the intrinsic apoptotic pathway. Bach1 functions unrelated ...

Added: October 22, 2026

Десинхронизация сенсомоторных ритмов при совершении квазидвижений, основанных на естественных движениях пальцев руки

Svirin E., Бердышев Д. А., Шишкин С. Л., Вестник Российского государственного медицинского университета 2026 № 3 С. 42–50

Quasi-movements (QMs), which are movement attempts minimized to the point of movement extinction, evoke EEG patterns similar to those of real movement. QMs can model attempted movement in healthy subjects and are therefore of interest as an alternative to motor imagery (MI) in rehabilitation brain–computer interfaces (BCIs), in which the attempted movement of the paralyzed ...

Added: October 22, 2026

Large amyloid plaques associate with early behavioral alterations in 6-month-old APPswe/PS1dE9 mice

Sitdikova K., Tsoy A., Chaprov K. et al., Journal of Neuropathology and Experimental Neurology 2026 Article nlag078

Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alterations remains unclear. We used 6-month-old female APPswe/PS1dE9 mice, a model of early amyloid-dominant pathology, to assess cognition and emotionality across a battery of behavioral tests. Amyloid ...

Added: October 22, 2026

Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice

Kassenova A., Svirin E., Sitdikova K. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 11 Article 4994

Added: October 22, 2026

Partial Serotonin Transporter Deficiency Modulates Plasma Metabolome, Arginine-Nitric Oxide Pathway and Emotional Behavior in Mice Exposed to Western Diet

Cespuglio R., Schmitt-Böhrer A., Deykin A. et al., Metabolites 2026 Vol. 16 No. 2 Article 117

Added: October 22, 2026

Исследование движения сферического фронта клеток в вязком матриксе: роль клеточных делений и взаимодействия клеток с матриксом при развитии опухолей

Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75

The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells, extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The problem formulation employs a multiphase model of a biological continuum, previously developed by the author, consisting of two actively interacting solid phases and a fluid. The propagation of ...

Added: October 20, 2026

Mismatch Negativity as a Neural Correlate of Auditory Learning: Evidence From Implicit and Explicit Fine Frequency Discrimination Training

Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598

Added: October 19, 2026

Interpreting antiviral effects: from experimental measurements to mechanistic viral dynamics

Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001

Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...

Added: October 15, 2026

Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids

Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260

Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...

Added: October 14, 2026

Динамика изолированного поселения Spermophilus Suslicus (Rodentia, Sciuridae) в Липецке (Европейская Россия), его перспективы и роль в сохранении вида

Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39

Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity. Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined everywhere. In 2015, in Russia experimental ...

Added: October 13, 2026

Detailed data on anatomy of the coelomic system and ultrastructure of the lophophore coelom in brachiopod Novocrania anomala with discussion of the phylogenetic significance

Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195

Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...

Added: October 11, 2026

HLA class I escape drives the evolution of SARS-CoV-2 in human populations

Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20

The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...

Added: October 2, 2026

Pericyte-derived cancer-associated fibroblasts correlate with poor survival and are enriched after chemoradiotherapy in glioblastoma

Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902

Added: October 2, 2026

Профессиональная учебная практика: I курс. Введение в биотехнологию, клеточную и молекулярную биологию : учебно-методическое пособие для студентов и преподавателей. Третье издание, пересмотренное

Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.

This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...

Added: September 30, 2026

Пути повышения эффективности применения водородных топливных элементов (протонообменной мембраны) на энергетических средствах

Абрамова С. В., Дальневосточный аграрный вестник 2024 Т. 18 № 2 С. 106–114

Для повышения экологической безопасности в настоящее время большое внимание уделяется использованию в качестве энергоносителей альтернативных источников энергии, что в значительной мере позволяет снизить токсичность выхлопных газов. Значительная роль отводится внедрению в отрасли сельского хозяйства альтернативных видов энергии, основанных на водородных топливных элементах. Для автомобильного транспорта в последние годы широкое применение получило использование в качестве источника ...

Added: September 24, 2025

Исследование регулирования соотношения и суммарного массового расхода компонентов топлива маршевого двигателя перспективного разгонного блока

Balakin S., Панасик Д. С., Федоров В. И., Космическая техника и технологии 2023 Т. 2(41) № 2 С. 22–31

The paper presents operating principles of the path for controlling the ratio and the total mass flow rate of propellant components in the high-efficiency engine for an advanced upper stage, and a procedure for studying the effects of destabilizing factors on the accuracy of maintaining the ratio and the total mass flow rate of propellant components. It provides an ...

Added: March 26, 2024

Yttrium-Iron Garnet Film Magnetometer for Registration of Magnetic Nano- and Submicron Particles: In Vitro and in Vivo Studies

Koshev N., Kapralov P., Evstigneeva S. et al., IEEE Transactions on Biomedical Engineering 2024 Vol. 71 No. 1 P. 122–129

In the current article, we present a new kind of magnetometer for quantitative detection of magnetic objects (magnetic nano- and submicron particles) in biological fluids and tissues. The sensor is based on yttrium-iron garnet film with optical signal registration system. Inheriting the working principle of a fluxgate magnetometers, the sensor works at a room-temperature, its ...

Added: August 29, 2023

Ion-Sensitive Three-Terminal Device as a Universal Hybrid Platform With TiO2 Nanowires on the Channel

Dalal A., Bebarta A., Paul A. D. et al., IEEE Sensors Journal 2023 Vol. 23 No. 3 P. 1917–1924

We developed a three-terminal ion-sensitive device (TTISD) as a proton (H+) and arsenic (As3+) sensor for the detection of glucose and As(III) dissolved in water. The TTISD was fabricated using the e-beam evaporation and glancing angle deposition (GLAD) technique. The TiO2 nanowires (NWs) were grown by GLAD on the conducting nafion channel of the TTISD ...

Added: June 26, 2023

Использование патентной классификации для поиска биомедицинской информации

Блохина Ю. В., Ilin A., Биоорганическая химия 2021 Т. 47 № 6 С. 768–774

Патентная литература представляет собой неотъемлемую и значительную часть знаний человечества, пренебрежение которой может негативным образом сказаться на качестве работы исследователя. Поиск по патентным базам помогает как разыскивать подробные технические данные об объектах или процессах, так и оценивать возможности патентования собственных разработок. При этом подобный поиск несколько отличается от использования стандартных интернет-поисковиков или систем научного цитирования. ...

Added: October 28, 2021

Use of Patent Classification in Searching for Biomedical Information

Blokhina Y. V., Ilin A., Russian Journal of Bioorganic Chemistry 2021 Vol. 47 No. 6 P. 1225–1230

Patent literature is an integral and significant part of human knowledge, the disrespect for which can negatively affect the quality of a researcher’s work. A search in patent databases helps both to look for detailed technical data on objects or processes and to evaluate the possibility of patenting one’s own results. At the same time, ...

Added: October 28, 2021

Genotoxic effect of 2,2’-bis(bicyclo[2.2.1] heptane) on bacterial cells

Kessenikh A., Gnuchikh E., Bazhenov S. et al., Plos One 2020 Vol. 15 No. 8 Article e0248251

The toxic effect of strained hydrocarbon 2,2'—bis (bicyclo[2.2.1]heptane) (BBH) was studied using whole-cell bacterial lux-biosensors based on Escherichia coli cells in which luciferase genes are transcriptionally fused with stress-inducible promoters. It was shown that BBH has the genotoxic effect causing bacterial SOS response however no alkylating effect has been revealed. In addition to DNA damage, there is ...

Added: March 2, 2021

Markets for Purchased Farm Inputs in Russia

Serova E.V., Shik O.V., Comparative Economic Studies 2005 Vol. 47 No. 1 P. 154–166

Russian policy makers argue that agriculture suffers from decapitalisation due to financial constraints faced by producers. This view is the basis for the national agricultural policy, which emphasises reimbursement of input costs and substitutes government and quasi-government organisations for the missing market institutions. The article evaluates the availability of purchased farm inputs, the efficiency of ...

Added: December 12, 2018

Автоматизация планирования потребности в топливе для автомобильных перевозок

Dorofeev A., Курганов В. М., Грязнов М. В., Вестник Тверского государственного университета. Серия: Экономика и управление 2018 № 2 С. 187–195

Целью исследования является определение способов снижения трудоемкости и повышения точности расчетов в планировании потребности в топливе для автотранспортных средств при работе на маршрутах. Предложенная компьютерная программа существенно снижает вероятность ошибки персонала при расчетах и позволяет формировать справочную базу данных предприятия. Для снижения отклонения результатов расчетов от объективной потребности в топливе, предложено проведение контрольных замеров с использованием спутниковых навигационных систем и уточнение поправочных коэффициентов, учитывающих ...

Added: August 31, 2018