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Response-adaptive randomization for multiarm clinical trials using context-dependent information measures
Biometrical Journal. 2023. Vol. 65. No. 8. Article 2200301.
Theoretical-information approach applied to the clinical trial designs appeared to bring several advantages when tackling a problem of finding a balance between power and expected number of successes (ENS). In particular, it was shown that the built-in parameter of the weight function allows finding the desired trade-off between the statistical power and number of treated patients in the context of small population Phase II clinical trials. However, in real clinical trials, randomized designs are more preferable. The goal of this research is to introduce randomization to a deterministic entropy-based sequential trial procedure generalized to multiarm setting. Several methods of randomization applied to an entropy-based design are investigated in terms of statistical power and ENS. Namely, the four design types are considered: (a) deterministic procedures, (b) naive randomization using the inverse of entropy criteria as weights, (c) block randomization, and (d) randomized penalty parameter. The randomized entropy-based designs are compared to randomized Gittins index (GI) and fixed randomization (FR). After the comprehensive simulation study, the following conclusion on block randomization is made: for both entropy-based and GI-based block randomization designs the degree of randomization induced by forward-looking procedures is insufficient to achieve a decent statistical power. Therefore, we propose an adjustment for the forward-looking procedure that improves power with almost no cost in terms of ENS. In addition, the properties of randomization procedures based on randomly drawn penalty parameter are also thoroughly investigated.
Language:
English
Publication based on the results of:
Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
Added: July 16, 2026
Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Kuninets A., Malygina E., Leevik A. G. et al., Journal of Computer Virology and Hacking Techniques 2026 No. 22 Article 62
In this work, we investigate the application of Barnes–Wall lattices in post-quantum cryptographic schemes. We survey and analyze several constructions of Barnes–Wall lattices, including subgroup chains, the generalized k-ing construction, and connections with Reed-Muller codes, highlighting their equivalence over both Z[i] and Z. Building on these structural insights, we introduce a new algorithm for efficient ...
Added: July 16, 2026
Silakov D., Системный администратор 2026 № 5 С. 46–51
В предыдущей статье про Open Source в КНР [1] мы рассказали про Alibaba – крупную корпорацию, занимающую тридцатое место в рейтинге самых значимых мировых брэндов за 2025 год [2]. Место почетное, но не первое среди китайских компаний – на тринадцатом месте расположилась Tencent, разработчик WeChat и ряда других продуктов, широко используемых нашими восточными соседями. Tencent ...
Added: July 14, 2026
IEEE, 2026.
Added: July 13, 2026
Switzerland: Springer, 2026.
This volume contains the refereed proceedings of the 25th International Conference on Mathematical Optimization Theory and Operations Research (MOTOR 2026) 1 held during July 6–11 in a picturesque place near Lake Baikal, Irkutsk, Russia. The MOTOR conference is a direct successor and scientific inheritor of several prominent events on mathematical programming, combinatorial and stochastic optimization, ...
Added: July 12, 2026
Шиманогов И. Н., Vyalyi M., Дискретный анализ и исследование операций 2025 Т. 32 № 4(166) С. 213–230
A well-studied class of algorithmic problems is that of regular realizability: checking the non-emptiness of the intersection of a regular language with a given language. This problem has a natural algebraic interpretation: verifying whether an element of a Boolean algebra belongs to the kernel of a certain homomorphism. This motivates the consideration of an analogous ...
Added: July 12, 2026
Surkov A., Ignatenko V., Koltcov Sergei, Computers, Materials and Continua 2026
Large language models have recently demonstrated promising capabilities in mathematical reasoning; however, their performance on tasks requiring strict symbolic manipulation, such as solving differential equations, remains limited, especially for compact models. In this work, we investigate whether activation steering combined with reinforcement learning can improve the quality of solutions generated by pretrained language models without ...
Added: July 8, 2026
Springer, 2027.
The series Lecture Notes in Computer Science (LNCS), including its subseries Lecture Notes in Artificial Intelligence (LNAI) and Lecture Notes in Bioinformatics (LNBI), has established itself as a medium for the publication of new developments in computer science and information technology research, teaching, and education. LNCS enjoys close cooperation with the computer science R & ...
Added: July 8, 2026
IEEE, 2026.
The purpose of the 2026 IEEE Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT) is to bring together researchers and practitioners from multiple areas of radio science, including biomedical engineering, radioelectronics, microelectronics, information technology, smart energy, information security and others. ...
Added: July 8, 2026
Маликов М. А., Монахова Э. А., Rzaev E. et al., Ученые записки Казанского университета. Серия: Физико-математические науки 2026 Т. 168 № 2 С. 269–286
This article examines series of families of two-dimensional circulant networks with rectangular
L -shapes, optimal in diameter, as network-on-chip topologies with a minimal number of crossings
between the links and a bounded length of the maximum link that does not depend on the network
size. New network-on-chip routing algorithms, which use the coordinates of three adjacent zeros in
the ...
Added: July 8, 2026
Pilé I., Deng Y., Shchur L., Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 114 No. 1 Article 014101
We investigate the spatial overlap of successive spin configurations in Markov chain Monte Carlo simulations using the local Metropolis algorithm and the Swendsen-Wang and Wolff cluster algorithms. We examine the dynamics of these algorithms for models in different universality classes: Ising model, Potts model with three components, and four-state Potts model. The overlap of two ...
Added: July 6, 2026
М.: Наука и технологии, 2026.
«Телекоммуникации» ежемесячный рецензируемый производственный, информационно-аналитический и учебно-методический журнал выходит в свет с июля 2000 г.
Для руководителей и работников промышленности, научно-исследовательских и проектно-конструкторских институтов, высших учебных заведений, аспирантов и студентов, а также для специалистов, разрабатывающих, выпускающих и эксплуатирующих средства телекоммуникаций.
Новости разработок и производства, прогнозы развития, защита информации, Нормативные, справочные, аналитические и учебно-методические материалы.
Переход к глобальному информационному ...
Added: July 4, 2026
МФТИ, 2025.
абота редакции научного журнала «Труды Московского физико-технического института» (кратко «Труды МФТИ»), редакционной коллегии и редакционного совета осуществляется в соответствии с Положением, утвержденным ректором института. В состав редакционной коллегии входят руководители института, факультетов, институтских и факультетских кафедр. Главный редактор журнала —президент МФТИ, член-корр. РАН Кудрявцев Н.Н.
Журнал «Труды МФТИ» входит в базу данных РИНЦ (Российский Индекс Научного Цитирования) и доступен в электронной ...
Added: July 4, 2026
Hualin M., Jie Z., Jerome Y. et al., Journal of Internet Technology 2026 Vol. 27 No. 3 P. 367–382
In open, interference-prone scenarios, the scarcity of precisely annotated signal samples limits the application of deep learning–based modulation identification, which generally relies on extensive labeled data for stability. Relation Networks, as an emerging class of deep learning models, exhibit rapid convergence in few-shot learning tasks. Motivated by the fast convergence property of relation-based learning and ...
Added: July 3, 2026
Osipov D., Информационно-управляющие системы 2026 № 3 С. 49–62
Introduction: In many communication systems under construction and those to be created power control and channel estimation techniques developed for the previous generation communication systems fail to provide desired precision. One way to solve this problem is to use order-statistics-based reception techniques that do not need channel estimation or power control. To ensure the desired ...
Added: July 3, 2026
Springer, 2026.
This book presents established and new research on the close connections between graph games and systems of logic, particularly existing and newly designed modal logics. The volume utilizes two graph games – the sabotage game and the hide-and-seek game – to demonstrate the natural interplay between designing new graph games and exploring new kinds of ...
Added: June 30, 2026
Netherlands: ScienceDirect, 2025.
No ...
Added: June 28, 2026
Seidel A., Weske M., Montali M. et al., Information Systems 2026 Vol. 141 Article 102728
Business process management employs process models and event logs to represent the behavior of the information systems under study. Traditional case-centric notions consider the order of activities and events in isolated process instances. The emerging field of object-centric processes challenges this assumption by putting objects in the center. Object-centric process mining and modeling approaches identify ...
Added: June 27, 2026
IEEE, 2024.
A.S. Popov Russian Science and Technical Society with support from V. A. Trapeznikov Institute of Control Sciences, V.A. Kotelnikov Institute of Radio Engineering and Electronics, Autex Ltd. is leading the ХХVIII International Conference «Digital Signal Processing and its Applications — DSPA-2024» ...
Added: June 27, 2026
Kapuza A., Andriasian Lilit, Open Learning 2026 Vol. 41 No. 2 P. 228–244
This study investigates the effectiveness of brief reflection interventions designed to support self-regulated learning in a short, Massive Open Online Course for in-service teachers. Two types of text-based reflection prompts were tested in a randomised controlled trial with over 5,000 participants. Learners were randomly assigned to one of three groups: (1) directed prompts focused on ...
Added: August 12, 2025
Myachykov A., Scheepers C., Discourse Processes 2024 P. 1–10
Russell Tomlin’s groundbreaking work laid a foundation for the explorations of the interplay between linguistic and nonlinguistic factors determining structural choice during sentence production. The present article investigates the interplay between two such factors, lexical priming and visual cueing, which may prioritize a particular referent of an event for privileged subject status within a sentence. To this end, ...
Added: February 21, 2025
Kasianova K., Kelbert M., Mathematics 2024 Vol. 12 No. 21 Article 3321
In models with insufficient initial information, there is a possibility of error in their
estimation which can lead to a suboptimal choice being made; however, a delay in implementation
can also lead to losses. This paper examines an extension of information-theoretic approaches
designed to address this classical dilemma, focusing on balancing the expected profits and the
information needed to ...
Added: October 22, 2024