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News
August 24, 2026
Researchers Develop Method for Direct Generation of Regulatory DNA
Researchers at HSE University have developed a model for generating promoters and enhancers—DNA sequences that regulate gene activity. The model works directly with DNA nucleotides, without first transforming them into a continuous numerical representation. This solution could be useful for applications in synthetic biology and gene therapy. The study results were presented at the ICLR 2026 Workshop ‘Generative AI in Genomics (Gen^2): Barriers and Frontiers.’
August 21, 2026
Social Integration: At the Crossroads of Knowledge and Values
The International Laboratory for Social Integration Research (ILSIR) at HSE University studies the challenges faced by vulnerable groups and explores ways to help them participate fully in everyday life. To develop effective solutions, the laboratory’s researchers combine cutting-edge methods with practical fieldwork. In this interview with the HSE News Service, Laboratory Head Elena Iarskaia-Smirnova discusses the laboratory’s work.
August 18, 2026
HSE Scholar Presents Research on Postcards in Brazil and South Korea
Timur Khusyainov, Deputy Dean of theFaculty of Humanities atHSE University–Nizhny Novgorod, took part in two international conferences—the XVI World Congress of Rural Sociology in Porto Alegre, Brazil, and the 36th Annual Conference of the Alliance of Digital Humanities Organisations (DH2026) in Daejeon, South Korea. On his way to the conferences, the researcher also visited several other places, where he presented the experience of the Pochtovoe educational project.

 

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Two approaches to determining similarity of two digraphs

Journal of Computer and Systems Sciences International. 2012. Vol. 51. No. 5. P. 695–714.
Kokhov V. A.
An approach to solving the problem of determining similarity with application of a maximal common fragment of two graphs is considered. Its two main disadvantages are specified. Two new approaches to solving the problem of determining similarity of digraphs are proposedamp;: a generalized substructural-metric approach and an approach using a stratified system of matrix models of the digraph complexity. New features for investigating similarity of digraphs are formulated. The original problem of calculating similarity of layout of fragments in the digraph is formalized with account of quantitative and qualitative features of fragments of the digraph. A methodology, involving two systems of methods for solving the problem, is developed. The first system of methods takes into account the precise layout of fragments in the digraph, while the second one deals with the approximate layout of fragments. A new class of problems is distinguished, which consists in calculating similarity of digraphs with account of similarity of the layout of fragments of the specified type. An example of solving the problem of finding semantic networks that are most similar to a network-template is presented.
Research target: Computer Science
Priority areas: business informatics
Language: English
Keywords: semanticsmatrix modeltwo-graphsstratified systemssemantic networkqualitative featuresfirst systemsdirected graphsproblem solving
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