ИНСТИТУТ БИОИНФОРМАТИКИ. СБОРНИК ТЕЗИСОВ 2020/21

Targeted delivery of therapeutic agents using lipid vesicles is an important area of modern biomedicine. However, the intrinsic biological effects of such carriers on cells require further investigation. Nanoarchaeosomes represent one promising class of delivery vehicles. In the present study, we investigated the response of Caco-2 intestinal epithelial cells to unloaded nanoarchaeosomes. Their exposure was ...

Added: November 13, 2026

Impact of 5G NR-V2X Message Losses on Connected Vehicle Warning Functions

Физулин А. В., Stepanyants V., Amerikanov A. et al., FUTURE TRANSPORTATION 2026 Vol. 6 No. 6 Article 264

Cooperative warning functions depend on whether V2X information becomes available in time to influence vehicle control. This article presents an event-based co-simulation framework coupling SUMO, ns-3 (ms-van3t), 5G-LENA NR sidelink and application records, with Sionna RT enabled for the intersection scenario. In 140 emergency-vehicle-warning runs, reducing mean packet reception ratio (PRR) from 0.9412 to 0.0675 ...

Added: November 12, 2026

Structural model of decision support system for sustainable development of oil and gas companies

Stoianova A. D., Trofimets V. Y., Matrokhina K. V., International Journal of Engineering, Transactions A: Basics 2025 Vol. 38 No. 4 P. 701–709

The article considers the issue of managerial decision-making in an oil and gas company, which is related to the class of multi-criteria choice problems. To improve the validity of decisions in the context of companies’ sustainable development it is proposed to implement a Decision Support System (DSS). A brief review of the existing methods of ...

Added: November 10, 2026

EdFitter: a hybrid course recommendation system using large language models

Sergei Koltcov, Ryumin D., Alexandr Axyonov et al., PeerJ Computer Science 2026 Article 12:e4141

Educational institutions face increasing pressure to adapt their curricula to the rapidly evolving demands of the job market, and recommender systems can be important tools to guide students in selecting courses that align with their career goals. We present EdFitter, a hybrid course recommendation system that combines pretrained text embeddings for retrieval with large language ...

Added: November 10, 2026

Assessing density equilibration in confined Liquid–Liquid interfaces

Guskov T., Gerke K., Kondratyuk N. et al., Molecular Simulation 2026 Vol. 52 No. 7 P. 546 – 555

Equilibration is often assumed rather than tested in molecular dynamics studies of confined liquid–liquid interfaces, even though different physical properties may relax on different time scales. In this work, equilibration is examined using an automated truncation method based on the marginal standard error rule. Interfacial geometry, wetting behaviour, and density-related properties are analysed for liquid–liquid ...

Added: November 10, 2026

Influence of nuclear quantum effects on metastable states of warm dense hydrogen

Lukyanchuk V., Norman G., Kondratyuk N. et al., Scientific Reports 2026 Vol. 16 No. 1 Article 16435

Previously, it has been effectively shown that nuclear quantum effects (NQE) considerably influence the prediction of the warm dense hydrogen phase diagram. Here, we study the influence of NQE on the parameters of the conducting state formation in warm dense hydrogen using path integral molecular dynamics (PIMD) within the framework of the finite temperature density ...

Added: November 10, 2026

Machine Learning and Knowledge Discovery in Databases. Research Track and Applied Data Science Track. European Conference, ECML PKDD 2026, Naples, Italy, September 7–11, 2026, Proceedings

Springer, 2027.

This volume is Part VIII of the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2026, held in Naples, Italy, September 7–11, 2026. It contains 40 papers from the Research Track and the Applied Data Science Track and is published as volume 16948 of Lecture Notes in ...

Added: November 9, 2026

Artificial Intelligence for Software Engineering (AI4SE): A Review of Capabilities, Evaluation, and Verification Challenges

Avdoshin S.M., Pesotskaya E.Y., Proceedings of the Institute for System Programming of the RAS 2026 Vol. 38 No. 6, part 2 P. 133–146

Artificial intelligence has significantly reshaped contemporary software engineering practice, changing how software systems are designed, implemented, tested, and maintained. Recent advances in large language models and AI-assisted development tools have expanded the role of AI from supporting isolated tasks to participating in multiple stages of the software lifecycle. In many development settings, software is now created from high-level specifications ...

Added: November 8, 2026

MFL-ScrollNet: Recurrent Sliding-Window Detection for Panoramic Pipeline Magnetic Flux Leakage Images

Aleksei Samarin, Belous F., Торопов А. Г. et al., Technologies 2026 Vol. 14 No. 11 P. 1–21

Abstract Automated interpretation of magnetic flux leakage (MFL) data is central to condition assessment of long-distance oil and gas pipelines. Yet, full-resolution panoramas are difficult to process without either suppressing small anomalies through resizing or fragmenting elongated objects at sliding-window boundaries. We propose MFL-ScrollNet, a recurrent sliding-window detector that formulates panoramic analysis as an ordered sequence ...

Added: November 8, 2026

Proceedings 2026 IEEE International Conference on Joint Cloud Computing JCC 2026

IEEE Computer Society (Conference Publishing Services, CPS), 2026.

Added: November 7, 2026

Structural Basis of Picomolar Inhibition of Mammalian α-Amylases by a β-Defensin-Like Marine Peptide and its Use as an Antihyperglycemic Agent

Popkova D., Menshov A., Sintsova O. et al., International Journal of Biological Macromolecules (Нидерланды) 2026 Vol. 376 No. 1 P. 1–19

Reducing polysaccharide degradation through inhibition of α-amylases and α-glucosidases is one of the strategies for glycemic control in the treatment of diabetes mellitus. Here we report the identification and characterization of a new β-defensin-like miniprotein magnificamide-2 (Mgf-2), one of the most potent inhibitors of mammalian α-amylases with subnanomolar binding affinity (Ki of recombinant Mgf-2 is 0.029 nM against ...

Added: November 7, 2026

Biochemical synthesis of coproporphyrin III tetramethyl ester: a novel reaction found in mycobacteria.

Bagaeva D. I., Demina G. R., Panina I. S. et al., International Journal of Biological Macromolecules (Нидерланды) 2026 Vol. 358 No. 1 P. 1–19

It was shown previously that mycobacteria (Mycobacterium smegmatis and Mycobacterium tuberculosis) accumulate tetramethyl ether of coproporphyrin III (TMC) during transition to dormant state. However, the enzymes involved in TMC synthesis remained unknown. Here we have identified a new M. smegmatis methyltransferase MSMEG_0614 (CPmtA) that catalyzes the S-adenosyl-L-methionine-dependent conversion of coproporphyrin (CP) into TMC through sequential methylation of its carboxyl ...

Added: November 7, 2026

Detecting the undetectable: benchmarking AI-generated text

Sergey Avdoshin, Elena Pesotskaya, Saleh H. et al., Procedia Computer Science 2026 Vol. 292 P. 1332–1341

The rapid development of generative large language models (LLMs) has intensified the need for reliable methods capable of distinguishing AI-generated text from human writing, especially in academic and professional settings. This paper presents the results of a systematic benchmarking study evaluating the performance and limitations of contemporary LLM-text detectors applied to Russian-language academic content. We introduce ...

Added: November 7, 2026

Open-channel block of human TRPV6 by polyamine spermine

Neuberger A., Veretenenko I. I., Shalygin A. et al., Nature Communications 2026 Vol. 17 No. 1 P. 1–13

Polyamines are organic cations that are present at sub-millimolar concentrations in the cytoplasm and extracellular fluids and serve as versatile modulators of TRP channels, fine-tuning their functions in physiological and pathological contexts, including pain, inflammation and cancer. Despite extensive functional studies, the structural basis by which polyamines regulate TRP channels remains unclear. Here, we combine calcium imaging, electrophysiology, cryo-electron microscopy, mutagenesis ...

Added: November 7, 2026

The locking mechanism of human TRPV6 inhibition by intracellular magnesium

Neuberger A., Shalygin A., Veretenenko I. I. et al., Nature Communications 2025 Vol. 16 No. 1 P. 1–16

TRPV6 is a member of the vanilloid subfamily of transient receptor potential channels, which serves as the master regulator of Ca2+ homeostasis. TRPV6 functions as a constitutively active Ca2+ channel, and emerging evidence indicates that its overactivity underpins the progression of several human diseases, including cancer. Hence, there is a pressing need to identify TRPV6 inhibitors in conjunction with a ...

Added: November 7, 2026

PrimeKV: Preserving critical KV cache without attention scores for long-context inference

Zhang Z., Ilvovsky D., Neurocomputing 2027 Vol. 710

Efficient management of the Key-Value (KV) cache is essential for deploying large language models (LLMs) in long-context scenarios, where memory requirements often exceed the capacity of resource-constrained hardware. Many existing training-free compression algorithms typically rely on attention-driven heuristics, but exhibit two key limitations. First, they require explicit attention score computation, which is difficult to reconcile ...

Added: November 5, 2026

Circadian clock adjusted classes improve sleep, circadian health, and academic performance in medical freshmen

Gubin D., Danilova L., Kolomeichuk S. et al., Chronobiology International 2026 P. 1–12

University students often experience circadian misalignment with academic schedules, which may impair performance. This study evaluated whether a later-start schedule improves academic outcomes and circadian rhythms in first-year medical students. Incoming students (n = 220) completed the Munich Chronotype Questionnaire; those with high social jetlag (SJL >120 min, n = 71) were randomized into either a later-start schedule (LS; ...

Added: November 5, 2026

A Multimodal Framework for Aphasia Severity Classification in Russian

Kolmogorova A., Ekaterina Yavshitz, Margolina A. et al., Association for Computational Linguistics, 2026.

Automatic classification of aphasia severity presents persistent challenges, particularly for languages with limited clinical speech re sources such as Russian. This paper explores a multimodal approach to severity estimation that combines acoustic and semantic representa tions of pathological speech. Acoustic features are extracted using pretrained Wav2Vec 2.0 models, while semantic information is obtained from the ...

Added: November 4, 2026

Findings of the Association for Computational Linguistics: EMNLP 2026

Association for Computational Linguistics, 2026.

Findings of the Association for Computational Linguistics: EMNLP 2026 ...

Added: November 3, 2026

PULSE: Psychological Characteristics Unified Learning via Speech-based Estimation

Abdulkhadirov T., Ryumina E., Ryumin D. et al., Expert Systems with Applications 2026 Vol. 334 P. 1–29

Assessing human psychological characteristics from speech requires models that can jointly capture affective states, expressive behavior, and relatively stable personality traits. However, most existing speech-based frameworks address isolated tasks and use separate task-specific models. This leads to model proliferation and complicates inference in real-world intelligent systems. Unified models are also difficult to develop because few ...

Added: November 3, 2026

Vague Stimulating Ideas, Images and Metaphors in Scientific Thinking: Researchers’ Work with Horizons of Unclear Knowledge

Poddiakov A., Integrative Psychological and Behavioral Science 2026 Vol. 60 No. 4 P. 1–50

Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, and “ability to engage with not-knowing” (de Freitas) is also a crucially important source of scientific creativity. Starting from studies by C. S. Peirce and B. Russell, scientists have developed tools for working with increasingly accurate ...

Added: November 3, 2026

Перспективы развития дата-центров для обработка данных по биоинформатике и биомедицине

Gorbunov A. A., Исаев Е. А., Приборы и системы. Управление, контроль, диагностика 2026 № 1 С. 42–46

В статье рассматриваются современные тенденции в развитии дата-центров, специализирующихся на обработке биоинформатических и биомедицинских данных. Особое внимание уделено применению искусственного интеллекта для оптимизации работы дата-центров и анализа больших объемов биологических данных. Представлен обзор современных технологий и архитектурных решений, позволяющих обрабатывать растущие объемы данных в области биоинформатики и биомедицины. Обсуждаются перспективы развития специализированных дата-центров в контексте экспоненциального роста ...

Added: October 12, 2026

Анализ алгоритмов квантовых вычислений в биомедицине

Gorbunov A. A., Григорьев А. А., Демидов Л. Н. et al., Приборы и системы. Управление, контроль, диагностика 2025 № 7 С. 20–24

Быстрое развитие технологии квантовых вычислений потенциально может произвести революцию в сложных вычислениях в физических, химических и биологических областях за счет использования квантовой суперпозиции и запутанности. Квантовые компьютеры используют кубиты, способные существовать в нескольких состояниях одновременно, в отличие от классических битов. Эта функция позволяет хранить и обрабатывать больше информации, что дает значительное преимущество при решении задач с обширным пространством ...

Added: October 12, 2026

A Three-Party W-State Quantum Secret Sharing Protocol with X-Gate Encoding and Forbidden-Outcome Detection

Timur Teregulov, Elena R. Loubenets, / Series Quantum Physics "arXiv". 2026. No. 2609.31472.

We develop a new three-party quantum secret-sharing (QSS) protocol based on a three-qubit W state. This protocol encodes the secret-sequence bits using X gates and employs randomly selected Hadamard operations and measurement bases to generate information and security-test rounds. We evaluate the efficiency of the proposed protocol and analyze its security against an internal adversary ...

Added: September 28, 2026