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Researchers at HSE University employed a new method to model hypoxia in placental cells during pregnancies complicated by preeclampsia and identified molecular markers of tissue hypoxia. Since hypoxia is one of the key mechanisms underlying preeclampsia, these findings are important for a more accurate and timely diagnosis of the disease and for the development of effective treatment methods. The paper has been published in Placenta.
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1,5-Hydride-Shift-Triggered Cyclization for the Synthesis of Unsymmetric Julolidines

Synthesis. 2021. Vol. 53. No. 24. P. 4689–4699.
Shirokova V., Ikonnikova V., Solyev P., Lushpa V., Korlyukov A., Volodin A., Baleeva N., Baranov M., Mikhaylov A. A.

Directly accessible 8-substituted tetrahydroquinolines undergo 1,5-hydride shift-triggered cyclization to provide hardly accessible julolidine derivatives in 20-98% yield under scandium (III) triflate catalysis. The scope of the reaction, several follow-up transformations and a remarkable side-process discovered during the conditions optimization are highlighted.

Research target: Chemistry
Language: English
DOI
Text on another site
Keywords: catalysisjulolidine1,5-hydride shiftredox-neutral reactiontetrahydroquinoline
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